SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 TYR A  89
ASP A 178
HIS A 296
ASP A 297
ARG A 371
 MLR  A 701 (-4.0A)
MLR  A 701 (-3.0A)
MLR  A 701 (-4.0A)
MLR  A 701 (-2.9A)
MLR  A 701 (-2.9A)
 0.68A 1dedA-5h05A:
33.1		 1dedA-5h05A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 5h05 AMYP
(marine
metagenome) 		6 / 12 TYR A  89
ARG A 176
ASP A 178
HIS A 296
ASP A 297
ARG A 371
 MLR  A 701 (-4.0A)
MLR  A 701 (-3.7A)
MLR  A 701 (-3.0A)
MLR  A 701 (-4.0A)
MLR  A 701 (-2.9A)
MLR  A 701 (-2.9A)
 0.58A 1dedB-5h05A:
36.1		 1dedB-5h05A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5h05 AMYP
(marine
metagenome) 		4 / 7 PHE A  69
SER A  71
PHE A 123
PHE A 101
 None
 1.05A 1fxvA-5h05A:
undetectable
1fxvB-5h05A:
undetectable		 1fxvA-5h05A:
15.42
1fxvB-5h05A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h05 AMYP
(marine
metagenome) 		5 / 12 LEU A 397
LEU A 338
PHE A  23
ALA A 374
LEU A 390
 None
 1.12A 1kt5A-5h05A:
undetectable		 1kt5A-5h05A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 5h05 AMYP
(marine
metagenome) 		7 / 12 TYR A  89
HIS A 129
ARG A 176
ASP A 178
TRP A 223
HIS A 296
ASP A 297
 MLR  A 701 (-4.0A)
MLR  A 701 (-4.2A)
MLR  A 701 (-3.7A)
MLR  A 701 (-3.0A)
None
MLR  A 701 (-4.0A)
MLR  A 701 (-2.9A)
 0.35A 1mxdA-5h05A:
26.8		 1mxdA-5h05A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5h05 AMYP
(marine
metagenome) 		4 / 8 THR A 337
ASN A 295
LEU A 298
GLU A 262
 None
 0.96A 1mxgA-5h05A:
27.2		 1mxgA-5h05A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h05 AMYP
(marine
metagenome) 		4 / 7 ILE A 310
ASP A 303
GLY A 302
TYR A 351
 None
CA  A 703 (-3.4A)
None
None
 0.87A 1rtsB-5h05A:
undetectable		 1rtsB-5h05A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 TYR A 422
ASP A 247
ASN A 278
TYR A 332
ILE A 415
 None
 1.35A 1xvaB-5h05A:
0.4		 1xvaB-5h05A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5h05 AMYP
(marine
metagenome) 		4 / 6 TYR A 217
ALA A  62
THR A 337
ASN A 290
 None
 1.17A 1yvpB-5h05A:
undetectable		 1yvpB-5h05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5h05 AMYP
(marine
metagenome) 		5 / 9 ALA A 352
ALA A 260
GLY A 264
GLY A 308
ILE A 310
 CA  A 703 ( 4.9A)
None
None
None
None
 1.09A 2v7bA-5h05A:
undetectable		 2v7bA-5h05A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5h05 AMYP
(marine
metagenome) 		5 / 9 ALA A 352
ALA A 260
GLY A 264
GLY A 308
ILE A 310
 CA  A 703 ( 4.9A)
None
None
None
None
 1.05A 2v7bB-5h05A:
undetectable		 2v7bB-5h05A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 ILE A  48
PHE A 486
ALA A 484
ALA A 324
LEU A 293
 None
 1.16A 2x2nD-5h05A:
undetectable		 2x2nD-5h05A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h05 AMYP
(marine
metagenome) 		4 / 5 SER A 327
TYR A 435
VAL A 254
TYR A 393
 None
 1.22A 2x7hA-5h05A:
undetectable		 2x7hA-5h05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h05 AMYP
(marine
metagenome) 		4 / 5 SER A 327
TYR A 435
VAL A 254
TYR A 393
 None
 1.23A 2x7hB-5h05A:
1.2		 2x7hB-5h05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5h05 AMYP
(marine
metagenome) 		5 / 9 VAL A 219
GLY A 216
GLY A 174
ILE A  15
ALA A  10
 None
 0.92A 2z0yB-5h05A:
2.3		 2z0yB-5h05A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5h05 AMYP
(marine
metagenome) 		5 / 12 TRP A  64
THR A  66
ASP A 124
VAL A 126
SER A  71
 None
 1.32A 3d4sA-5h05A:
undetectable		 3d4sA-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h05 AMYP
(marine
metagenome) 		6 / 12 GLY A 308
GLY A 264
ALA A 259
ARG A 321
ALA A 311
GLU A 317
 None
 1.27A 3g8bB-5h05A:
undetectable		 3g8bB-5h05A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5h05 AMYP
(marine
metagenome) 		5 / 12 TRP A  64
THR A  66
ASP A 124
VAL A 126
SER A  71
 None
 1.38A 3nyaA-5h05A:
undetectable		 3nyaA-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 5h05 AMYP
(marine
metagenome) 		4 / 5 PRO A  67
ILE A  68
TYR A 159
TRP A 188
 None
 1.17A 3phaA-5h05A:
13.3		 3phaA-5h05A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5h05 AMYP
(marine
metagenome) 		6 / 12 GLY A 125
VAL A 219
ALA A 163
ALA A 198
SER A 201
ASP A 196
 None
 1.36A 3sudD-5h05A:
undetectable		 3sudD-5h05A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5h05 AMYP
(marine
metagenome) 		4 / 8 TYR A  94
TYR A 152
LEU A 177
TRP A 188
 None
 1.10A 3uzzB-5h05A:
9.2		 3uzzB-5h05A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5h05 AMYP
(marine
metagenome) 		3 / 3 LEU A 110
MET A 104
ASP A  98
 None
 0.85A 3v5wA-5h05A:
undetectable		 3v5wA-5h05A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 5h05 AMYP
(marine
metagenome) 		5 / 11 GLY A 128
ARG A 176
ALA A 220
VAL A 183
PRO A 143
 None
MLR  A 701 (-3.7A)
None
None
None
 1.36A 4j4vD-5h05A:
undetectable
4j4vE-5h05A:
undetectable		 4j4vD-5h05A:
17.83
4j4vE-5h05A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h05 AMYP
(marine
metagenome) 		5 / 12 LEU A 273
LEU A 291
ALA A 325
SER A 327
LEU A 326
 None
 1.21A 4m11D-5h05A:
undetectable		 4m11D-5h05A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 VAL A 126
PRO A  67
THR A  66
SER A  22
GLY A  43
 None
 1.35A 4q15A-5h05A:
undetectable		 4q15A-5h05A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 VAL A 126
PRO A  67
THR A  66
SER A  22
GLY A  43
 None
 1.35A 4q15B-5h05A:
undetectable		 4q15B-5h05A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5h05 AMYP
(marine
metagenome) 		4 / 5 SER A 137
GLY A 140
ARG A 141
GLU A 139
 None
 1.28A 4r82A-5h05A:
undetectable
4r82B-5h05A:
undetectable		 4r82A-5h05A:
15.32
4r82B-5h05A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 VAL A 126
PRO A  67
THR A  66
SER A  22
GLY A  43
 None
 1.43A 4ydqB-5h05A:
undetectable		 4ydqB-5h05A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5h05 AMYP
(marine
metagenome) 		4 / 8 ASN A 148
PRO A 149
PHE A  90
TYR A  94
 None
None
MLR  A 701 (-4.5A)
None
 1.11A 5amkA-5h05A:
undetectable		 5amkA-5h05A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5h05 AMYP
(marine
metagenome) 		4 / 6 SER A 495
ASP A 424
ARG A 412
GLY A 410
 None
 0.77A 5cdnT-5h05A:
undetectable
5cdnU-5h05A:
undetectable		 5cdnT-5h05A:
22.45
5cdnU-5h05A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5h05 AMYP
(marine
metagenome) 		5 / 12 ALA A 259
GLN A  17
PHE A 301
GLY A 294
THR A 337
 None
 1.22A 5hfjH-5h05A:
undetectable		 5hfjH-5h05A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 5h05 AMYP
(marine
metagenome) 		5 / 10 SER A 244
PHE A 246
PRO A 335
ASN A  11
LEU A  13
 None
 1.45A 5l1fD-5h05A:
undetectable		 5l1fD-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 5h05 AMYP
(marine
metagenome) 		4 / 5 ARG A 100
THR A  34
HIS A  32
ASP A  82
 None
 1.45A 5mfxA-5h05A:
undetectable		 5mfxA-5h05A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 GLU A 262
VAL A 299
PRO A 313
GLU A 314
GLU A 342
 None
 1.44A 5mqtC-5h05A:
undetectable		 5mqtC-5h05A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5h05 AMYP
(marine
metagenome) 		5 / 10 TYR A 204
PRO A 214
ILE A 172
ILE A 167
VAL A 111
 None
 1.34A 5mzrA-5h05A:
undetectable		 5mzrA-5h05A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h05 AMYP
(marine
metagenome) 		4 / 8 ILE A 310
ASP A 303
GLY A 302
TYR A 351
 None
CA  A 703 (-3.4A)
None
None
 0.83A 5x5qD-5h05A:
undetectable		 5x5qD-5h05A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5h05 AMYP
(marine
metagenome) 		4 / 8 ILE A 310
ASP A 303
GLY A 302
TYR A 351
 None
CA  A 703 (-3.4A)
None
None
 0.82A 5x5qF-5h05A:
undetectable		 5x5qF-5h05A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 5h05 AMYP
(marine
metagenome) 		5 / 12 TYR A  89
HIS A 129
ASP A 178
HIS A 296
ASP A 297
 MLR  A 701 (-4.0A)
MLR  A 701 (-4.2A)
MLR  A 701 (-3.0A)
MLR  A 701 (-4.0A)
MLR  A 701 (-2.9A)
 0.55A 6ag0A-5h05A:
24.9		 6ag0A-5h05A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5h05 AMYP
(marine
metagenome) 		4 / 6 GLN A 182
VAL A 183
PRO A 149
ALA A 187
 None
 0.96A 6cduB-5h05A:
undetectable
6cduC-5h05A:
undetectable		 6cduB-5h05A:
19.25
6cduC-5h05A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5h05 AMYP
(marine
metagenome) 		5 / 12 LEU A 390
PHE A 258
VAL A 437
VAL A 254
LEU A  58
 None
 1.22A 6djzA-5h05A:
undetectable		 6djzA-5h05A:
16.72