SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		4 / 8 SER A1745
LEU A1769
ASP A1781
GLU A1817
 None
 1.08A 1mxgA-5h08A:
undetectable		 1mxgA-5h08A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		4 / 7 TYR A1756
VAL A1937
GLY A1938
THR A1978
 None
None
7WL  A2101 ( 3.7A)
7WL  A2101 ( 4.5A)
 0.93A 2a1mA-5h08A:
undetectable		 2a1mA-5h08A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		5 / 9 LEU A1946
VAL A1915
VAL A1931
ILE A1826
VAL A1824
 7WL  A2101 (-4.7A)
None
None
7WL  A2101 (-3.9A)
None
 1.30A 2l8mA-5h08A:
undetectable		 2l8mA-5h08A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		3 / 3 ASN A1754
ASN A1784
ARG A1972
 None
 0.80A 2rlcA-5h08A:
undetectable		 2rlcA-5h08A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		3 / 3 ARG A1766
ASP A1810
ASN A1750
 None
 0.84A 2zzmA-5h08A:
undetectable		 2zzmA-5h08A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		5 / 12 ASP A1987
VAL A1990
ASN A1960
VAL A1708
PHE A1704
 None
 1.09A 3dmfA-5h08A:
undetectable		 3dmfA-5h08A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		4 / 5 ILE A1815
PHE A1811
ASP A1810
GLU A1809
 None
 1.07A 3kp6A-5h08A:
undetectable
3kp6B-5h08A:
undetectable		 3kp6A-5h08A:
21.14
3kp6B-5h08A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		5 / 11 ILE A1798
ILE A1823
ILE A1783
VAL A1820
PRO A1928
 None
 0.92A 3tmzA-5h08A:
undetectable		 3tmzA-5h08A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		3 / 3 ARG A1755
TYR A1762
ASN A1746
 None
 0.75A 4ffwB-5h08A:
undetectable		 4ffwB-5h08A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		5 / 12 GLY A1936
ILE A1798
ASN A1786
SER A1934
PHE A1811
 None
 1.18A 4obwC-5h08A:
undetectable		 4obwC-5h08A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		3 / 3 MET A1825
GLN A1898
TYR A1864
 None
 1.09A 4udcA-5h08A:
undetectable		 4udcA-5h08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens) 		4 / 6 VAL A1931
VAL A1945
SER A1948
ILE A1953
 None
 1.08A 5jw1B-5h08A:
undetectable		 5jw1B-5h08A:
20.64