SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 10 ALA A 409
ASN A 454
ALA A 455
LEU A 427
VAL A 428
 None
 1.22A 1claA-5h0iA:
undetectable		 1claA-5h0iA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 11 LEU A 353
ASP A 349
HIS A  73
HIS A 175
CYH A 247
 None
 1.23A 1s9aA-5h0iA:
undetectable		 1s9aA-5h0iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 LEU A 353
ASP A 349
HIS A  73
HIS A 175
CYH A 247
 None
 1.30A 1s9aB-5h0iA:
undetectable		 1s9aB-5h0iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 6 PHE A 359
ARG A 360
ASN A 262
ASN A 346
 None
 1.21A 2nyrA-5h0iA:
4.3		 2nyrA-5h0iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 ILE A 393
GLY A 394
PHE A 398
LEU A 427
ILE A 457
 None
 1.18A 2y7kD-5h0iA:
undetectable		 2y7kD-5h0iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 7 ILE A 393
GLY A 394
PHE A 398
ILE A 452
 None
 0.83A 2y7wC-5h0iA:
undetectable		 2y7wC-5h0iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 11 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.34A 3g88A-5h0iA:
undetectable		 3g88A-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 11 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.34A 3g88B-5h0iA:
undetectable		 3g88B-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 12 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.35A 3g89A-5h0iA:
undetectable		 3g89A-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 11 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.35A 3g89B-5h0iA:
undetectable		 3g89B-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 12 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.34A 3g8bA-5h0iA:
undetectable		 3g8bA-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		6 / 12 GLY A 182
GLY A  64
ASP A 174
ALA A 216
ALA A 177
ALA A 138
 None
 1.35A 3g8bB-5h0iA:
undetectable		 3g8bB-5h0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 LEU A 353
ASP A 349
VAL A 345
HIS A  73
HIS A 175
 None
 1.24A 3hgiA-5h0iA:
undetectable		 3hgiA-5h0iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 7 ASP A 130
GLY A 154
THR A 153
ILE A 152
 None
 0.82A 4acaC-5h0iA:
2.5		 4acaC-5h0iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 GLU A 440
GLY A  67
TYR A 172
VAL A 180
TYR A 188
 None
 1.43A 4ffwB-5h0iA:
undetectable		 4ffwB-5h0iA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		3 / 3 LYS A 129
ASN A 140
ASP A 100
 None
 0.77A 4o1eA-5h0iA:
undetectable		 4o1eA-5h0iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		3 / 3 GLU A 405
ILE A 457
ALA A 409
 None
 0.63A 4wnwB-5h0iA:
undetectable		 4wnwB-5h0iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 7 MET A 222
PHE A 223
ALA A 197
LEU A 198
 None
 1.04A 4xk8A-5h0iA:
undetectable		 4xk8A-5h0iA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 5 LEU A 214
ALA A 191
ASN A 195
ILE A 226
 None
 1.13A 4y03B-5h0iA:
undetectable		 4y03B-5h0iA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 SER A 245
THR A 239
SER A 221
ILE A 449
ASP A 174
 None
 1.31A 4zjqD-5h0iA:
undetectable		 4zjqD-5h0iA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 10 VAL A  60
ILE A 170
LEU A 210
GLY A 147
ALA A 144
 None
 1.17A 5mxbA-5h0iA:
undetectable		 5mxbA-5h0iA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		5 / 12 LEU A 194
GLY A 220
ALA A 191
GLU A 243
THR A 237
 None
 1.09A 5x6yA-5h0iA:
2.6		 5x6yA-5h0iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 6 GLY A 313
GLN A 290
TYR A 213
TYR A 234
 None
 1.13A 6ag0A-5h0iA:
undetectable		 6ag0A-5h0iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5h0i ASPARAGINYL
ENDOPEPTIDASE
(Oldenlandia
affinis) 		4 / 6 GLY A 313
GLN A 290
TYR A 213
TYR A 234
 None
 1.19A 6ag0C-5h0iA:
undetectable		 6ag0C-5h0iA:
13.45