SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.91A 1jnoA-5h0uA:
undetectable		 1jnoA-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.91A 1jnoB-5h0uA:
undetectable		 1jnoB-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.93A 1magA-5h0uA:
undetectable		 1magA-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.93A 1magB-5h0uA:
undetectable		 1magB-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.96A 1nrmA-5h0uA:
undetectable		 1nrmA-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ALA A 154
VAL A 150
TRP A 151
 None
 0.96A 1nrmB-5h0uA:
undetectable		 1nrmB-5h0uA:
8.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 5 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.26A 1os2A-5h0uA:
27.8		 1os2A-5h0uA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.17A 1os2D-5h0uA:
27.8		 1os2D-5h0uA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.10A 1uttA-5h0uA:
28.1		 1uttA-5h0uA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.15A 1utzA-5h0uA:
28.4		 1utzA-5h0uA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.15A 1utzB-5h0uA:
28.4		 1utzB-5h0uA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 6 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.38A 1y93A-5h0uA:
28.1		 1y93A-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.11A 2hu6A-5h0uA:
28.1		 2hu6A-5h0uA:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 9 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.40A 2jihA-5h0uA:
10.1		 2jihA-5h0uA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 8 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.38A 2jihB-5h0uA:
7.4		 2jihB-5h0uA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 6 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.46A 2ow9A-5h0uA:
27.3		 2ow9A-5h0uA:
47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.16A 2ow9B-5h0uA:
27.6		 2ow9B-5h0uA:
47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.18A 2ozrC-5h0uA:
27.9		 2ozrC-5h0uA:
47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.22A 2ozrD-5h0uA:
28.1		 2ozrD-5h0uA:
47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.23A 2ozrE-5h0uA:
27.3		 2ozrE-5h0uA:
47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 HIS A 239
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.19A 2ozrF-5h0uA:
27.2		 2ozrF-5h0uA:
47.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 VAL A 162
ASP A 212
LEU A 245
ARG A 160
 None
CA  A 301 ( 3.0A)
None
None
 1.05A 2ziaA-5h0uA:
2.6		 2ziaA-5h0uA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 HIS A 201
GLU A 240
HIS A 243
 ZN  A 303 (-3.2A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
 0.39A 3ba0A-5h0uA:
25.6		 3ba0A-5h0uA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 9 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.43A 3hy7A-5h0uA:
10.5		 3hy7A-5h0uA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 9 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.39A 3hy7B-5h0uA:
10.4		 3hy7B-5h0uA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 5 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.12A 3kecA-5h0uA:
27.2		 3kecA-5h0uA:
48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 HIS A 239
GLU A 240
HIS A 243
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
 0.12A 3kecB-5h0uA:
27.4		 3kecB-5h0uA:
48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 5 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.43A 3likA-5h0uA:
28.1		 3likA-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.12A 3lilA-5h0uA:
28.2		 3lilA-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 5 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.16A 3ljgA-5h0uA:
28.0		 3ljgA-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 5 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.40A 3lkaA-5h0uA:
28.1		 3lkaA-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		5 / 6 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.44A 4a7bA-5h0uA:
27.7		 4a7bA-5h0uA:
48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 5 HIS A 201
HIS A 239
GLU A 240
HIS A 243
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
 0.17A 4a7bB-5h0uA:
27.8		 4a7bB-5h0uA:
48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 4 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.13A 5n5jA-5h0uA:
28.0		 5n5jA-5h0uA:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 5 HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.15A 5n5kA-5h0uA:
27.7		 5n5kA-5h0uA:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 ILE A 233
ASN A 130
CYH A 127
 None
EPE  A 305 ( 4.6A)
None
 0.80A 6bp4A-5h0uA:
undetectable		 6bp4A-5h0uA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 8 ASP A 188
SER A 189
TYR A 203
GLY A 116
 ZN  A 303 (-2.5A)
None
None
None
 1.11A 6giqL-5h0uA:
undetectable
6giqP-5h0uA:
undetectable
6giqT-5h0uA:
undetectable		 6giqL-5h0uA:
17.87
6giqP-5h0uA:
22.17
6giqT-5h0uA:
17.39