SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 11 PHE A 140
ASP A 259
HIS A 257
ASP A 212
LEU A 216
 None
 1.50A 1c3sA-5h12A:
undetectable		 1c3sA-5h12A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 11 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 None
 1.23A 1cmaA-5h12A:
undetectable
1cmaB-5h12A:
undetectable		 1cmaA-5h12A:
10.75
1cmaB-5h12A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 6 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 1.02A 1e7aB-5h12A:
undetectable		 1e7aB-5h12A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 12 ALA A 501
GLY A 499
GLU A 376
GLU A 378
LEU A 381
 None
 1.21A 1mj2A-5h12A:
undetectable
1mj2B-5h12A:
undetectable		 1mj2A-5h12A:
11.04
1mj2B-5h12A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 10 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 None
 1.22A 1mjqC-5h12A:
undetectable
1mjqD-5h12A:
undetectable		 1mjqC-5h12A:
11.04
1mjqD-5h12A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 11 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 None
 1.21A 1mjqI-5h12A:
undetectable
1mjqJ-5h12A:
undetectable		 1mjqI-5h12A:
11.04
1mjqJ-5h12A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 5 ILE A 568
SER A 412
LEU A 572
ASN A 569
 None
 1.19A 1y0xX-5h12A:
undetectable		 1y0xX-5h12A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 6 LEU A 651
VAL A 637
VAL A 742
ILE A 643
 None
 0.98A 2hyyB-5h12A:
undetectable		 2hyyB-5h12A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 None
 1.26A 2jfaA-5h12A:
undetectable		 2jfaA-5h12A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 None
 1.25A 2qxsA-5h12A:
1.9		 2qxsA-5h12A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 None
 1.23A 2qxsB-5h12A:
undetectable		 2qxsB-5h12A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 8 TYR A 218
MET A 190
ILE A 157
ASP A 215
 None
 1.11A 2xytH-5h12A:
undetectable		 2xytH-5h12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 7 TYR A 218
MET A 190
ILE A 157
ASP A 215
 None
 1.12A 2xytI-5h12A:
undetectable		 2xytI-5h12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 None
 0.72A 2zulA-5h12A:
undetectable		 2zulA-5h12A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 None
 0.72A 3dmhA-5h12A:
undetectable		 3dmhA-5h12A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 7 LEU A 275
TYR A 209
VAL A 220
ILE A 142
 None
 1.31A 3ik3B-5h12A:
undetectable		 3ik3B-5h12A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 TYR A 356
TYR A 494
GLU A 460
 None
 0.96A 3pfgA-5h12A:
undetectable		 3pfgA-5h12A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 12 ASP A   6
ILE A   2
ASP A 235
ARG A  17
PHE A  26
 None
 1.50A 3phaB-5h12A:
undetectable		 3phaB-5h12A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 7 GLU A 437
GLU A 520
GLY A 388
ARG A 519
 None
 0.91A 4fgzA-5h12A:
undetectable		 4fgzA-5h12A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 12 ILE A 206
LEU A 230
VAL A 220
ILE A 160
THR A 319
 None
 1.07A 4km2A-5h12A:
undetectable		 4km2A-5h12A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 ASP A 422
TRP A 517
SER A 452
 None
 0.98A 4lrhA-5h12A:
undetectable		 4lrhA-5h12A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 LEU A 358
ARG A 359
MET A 129
 None
 0.94A 4m11C-5h12A:
undetectable		 4m11C-5h12A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		4 / 5 TYR A 546
LEU A 404
GLU A 581
TYR A 580
 None
 1.40A 4olbA-5h12A:
undetectable		 4olbA-5h12A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 11 TYR A 320
HIS A 262
ASP A 212
PHE A 258
GLY A 211
 None
 1.38A 4qa0B-5h12A:
undetectable		 4qa0B-5h12A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		3 / 3 VAL A 644
GLU A 731
GLU A 735
 None
 0.92A 5jsdB-5h12A:
undetectable
5jsdC-5h12A:
2.0		 5jsdB-5h12A:
21.76
5jsdC-5h12A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5h12 DEEP VENT DNA
POLYMERASE
(Pyrococcus) 		5 / 9 PRO A 679
GLY A 709
VAL A 704
LEU A 705
ARG A 706
 None
 1.41A 5o96E-5h12A:
undetectable
5o96F-5h12A:
undetectable		 5o96E-5h12A:
17.48
5o96F-5h12A:
17.48