SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		3 / 3 ALA A  44
HIS A  45
VAL A  48
 None
 0.49A 1lqtB-5h1aA:
undetectable		 1lqtB-5h1aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		3 / 3 ALA A  44
HIS A  45
VAL A  48
 None
 0.49A 1lquB-5h1aA:
undetectable		 1lquB-5h1aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		5 / 12 ARG A  83
LEU A  89
LEU A 105
THR A 243
LEU A 245
 None
 1.20A 1og5A-5h1aA:
undetectable		 1og5A-5h1aA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		5 / 9 LEU A  84
ALA A  88
LEU A 245
LEU A 217
ALA A 215
 None
 1.36A 1sn0A-5h1aA:
undetectable
1sn0C-5h1aA:
undetectable		 1sn0A-5h1aA:
17.12
1sn0C-5h1aA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		4 / 6 GLN A  86
ASP A 244
GLU A 236
LEU A  89
 None
 1.20A 4ax8A-5h1aA:
undetectable		 4ax8A-5h1aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		5 / 12 LEU A 181
VAL A 113
ALA A 139
SER A 140
LEU A 144
 None
 1.27A 4m11A-5h1aA:
undetectable		 4m11A-5h1aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		5 / 12 LEU A 181
VAL A 113
ALA A 139
SER A 140
LEU A 144
 None
 1.11A 4o1zB-5h1aA:
undetectable		 4o1zB-5h1aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		5 / 9 ALA A 192
ILE A 196
GLY A 167
PRO A 136
VAL A 137
 None
 1.04A 5kr0A-5h1aA:
undetectable		 5kr0A-5h1aA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		4 / 6 HIS A 138
ASN A 111
VAL A 113
LEU A 135
 None
 1.21A 5xdhA-5h1aA:
undetectable
5xdhC-5h1aA:
undetectable		 5xdhA-5h1aA:
15.18
5xdhC-5h1aA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		4 / 5 HIS A 138
ASN A 111
VAL A 113
LEU A 135
 None
 1.25A 5xdhB-5h1aA:
undetectable		 5xdhB-5h1aA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG
(Microbacterium
sp.) 		4 / 5 HIS A 138
ASN A 111
VAL A 113
LEU A 135
 None
 1.20A 5xdhD-5h1aA:
undetectable		 5xdhD-5h1aA:
15.18