SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 4 ASP A 257
LEU A 252
LEU A 255
LEU A 253
 None
 1.38A 1u18A-5h1cA:
undetectable		 1u18A-5h1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 12 ILE A 220
ASP A 161
THR A 165
VAL A 264
ILE A 265
 None
None
ANP  A 602 ( 4.5A)
None
None
 1.32A 2yzqA-5h1cA:
undetectable		 2yzqA-5h1cA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 167
THR A 143
THR A 266
 None
 0.80A 3k2hB-5h1cA:
2.5		 3k2hB-5h1cA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 8 ASN A 290
ALA A 295
SER A 296
ARG A 299
 None
 1.00A 3kp6A-5h1cA:
undetectable		 3kp6A-5h1cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 9 ALA A 224
GLY A 288
ILE A 291
ILE A 122
ILE A 265
 None
 0.88A 3s43A-5h1cA:
undetectable		 3s43A-5h1cA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 9 ALA A 224
GLY A 288
ILE A 291
ILE A 122
ILE A 265
 None
 0.85A 3s45A-5h1cA:
undetectable		 3s45A-5h1cA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 7 LEU A 302
THR A 123
THR A 266
VAL A 264
 None
 0.73A 4ik7A-5h1cA:
undetectable		 4ik7A-5h1cA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 10 LEU A 255
LEU A 252
LEU A 249
ARG A 254
HIS A 244
 None
 1.10A 4mk4A-5h1cA:
undetectable		 4mk4A-5h1cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 10 LEU A 255
LEU A 252
LEU A 249
ARG A 254
THR A 225
 None
 1.40A 4mk4A-5h1cA:
undetectable		 4mk4A-5h1cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 7 THR A 266
ALA A 224
THR A 225
THR A 162
 None
 0.92A 4qw0K-5h1cA:
undetectable		 4qw0K-5h1cA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 7 THR A 266
ALA A 224
THR A 225
THR A 162
 None
 0.92A 4qw0Y-5h1cA:
undetectable		 4qw0Y-5h1cA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 12 ILE A 329
THR A 123
VAL A 264
LEU A 113
LEU A 109
 ANP  A 602 ( 4.2A)
None
None
None
None
 1.10A 4qzuC-5h1cA:
undetectable		 4qzuC-5h1cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 11 TYR A 159
ASP A 161
VAL A 264
GLN A 200
ALA A 194
 None
 1.18A 5d75A-5h1cA:
undetectable		 5d75A-5h1cA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		3 / 3 ASN A 188
TYR A 216
CYH A 144
 None
 1.10A 5lsuB-5h1cA:
undetectable		 5lsuB-5h1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		5 / 12 GLY A 335
PHE A 327
THR A 139
VAL A 174
LEU A 112
 None
 1.37A 5nz0A-5h1cA:
undetectable		 5nz0A-5h1cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens) 		4 / 8 LEU A 255
VAL A 221
LEU A 219
ILE A 160
 None
 0.92A 6cb4A-5h1cA:
undetectable		 6cb4A-5h1cA:
21.95