SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 8 ALA A 139
GLY A 176
ALA A 140
ILE A 173
 None
 0.67A 1gtnI-5h1qA:
undetectable
1gtnJ-5h1qA:
undetectable		 1gtnI-5h1qA:
11.34
1gtnJ-5h1qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 7 MET A 342
ALA A 140
TYR A 135
SER A 170
 None
 1.08A 1k5qA-5h1qA:
undetectable
1k5qB-5h1qA:
undetectable		 1k5qA-5h1qA:
19.90
1k5qB-5h1qA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 6 LEU A  26
TRP A 126
LEU A 137
PHE A 340
 None
 0.78A 1ru9H-5h1qA:
undetectable
1ru9L-5h1qA:
undetectable		 1ru9H-5h1qA:
18.80
1ru9L-5h1qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 6 LEU A  26
TRP A 126
LEU A 137
PHE A 340
 None
 0.83A 1rukH-5h1qA:
undetectable
1rukL-5h1qA:
undetectable		 1rukH-5h1qA:
18.80
1rukL-5h1qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 7 ASN A 294
TRP A 298
TRP A 126
SER A 195
 None
 1.23A 2o5yH-5h1qA:
undetectable
2o5yL-5h1qA:
undetectable		 2o5yH-5h1qA:
18.88
2o5yL-5h1qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		5 / 12 THR A 268
VAL A 266
VAL A 246
ASN A  73
TYR A 105
 None
 1.45A 3d4sA-5h1qA:
3.9		 3d4sA-5h1qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		5 / 12 THR A 268
VAL A 266
VAL A 246
ASN A  73
TYR A 105
 None
 1.42A 3nyaA-5h1qA:
3.0		 3nyaA-5h1qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		5 / 11 LEU A 213
LEU A 214
PHE A 242
LEU A 280
LEU A  46
 None
 1.16A 4dm8A-5h1qA:
undetectable		 4dm8A-5h1qA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		5 / 12 PHE A 147
GLY A 350
SER A 355
PHE A 165
ARG A 161
 None
 0.99A 4kowA-5h1qA:
undetectable		 4kowA-5h1qA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 6 TYR A 105
GLU A 274
LEU A  46
PHE A 277
 None
 1.29A 4twdB-5h1qA:
4.3
4twdC-5h1qA:
4.1		 4twdB-5h1qA:
23.13
4twdC-5h1qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 5 TYR A 219
GLU A 274
TYR A 104
PHE A 277
 None
 1.33A 4twdC-5h1qA:
4.1
4twdD-5h1qA:
3.1		 4twdC-5h1qA:
23.13
4twdD-5h1qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 6 TYR A 219
GLU A 274
LEU A 213
PHE A 277
 None
 1.31A 4twdF-5h1qA:
2.7
4twdG-5h1qA:
undetectable		 4twdF-5h1qA:
23.13
4twdG-5h1qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 6 TYR A 219
GLU A 274
TYR A 104
LEU A 213
 None
 1.18A 4twdF-5h1qA:
2.7
4twdG-5h1qA:
undetectable		 4twdF-5h1qA:
23.13
4twdG-5h1qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 7 THR A 268
LEU A 269
VAL A 108
TYR A 104
 None
 1.12A 5ov9A-5h1qA:
undetectable		 5ov9A-5h1qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 8 THR A 268
LEU A 269
VAL A 108
TYR A 104
 None
 1.09A 5ov9B-5h1qA:
undetectable		 5ov9B-5h1qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5h1q INNEXIN-6
(Caenorhabditis
elegans) 		4 / 7 THR A 211
PHE A 277
LEU A 280
SER A  43
 None
 1.08A 5uxcA-5h1qA:
undetectable		 5uxcA-5h1qA:
19.95