SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		5 / 12 GLY B 835
HIS B 849
ASN B 834
SER B 921
GLN B 833
 None
ZN  B1103 (-3.2A)
None
None
None
 1.50A 1qu3A-5h1uB:
undetectable		 1qu3A-5h1uB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		5 / 11 SER B 957
PRO B 962
PHE B 965
TYR B 959
VAL B 854
 None
 1.22A 3bmcA-5h1uB:
undetectable		 3bmcA-5h1uB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		5 / 12 SER B 957
PRO B 962
PHE B 965
TYR B 959
VAL B 854
 None
 1.27A 3bmcD-5h1uB:
undetectable		 3bmcD-5h1uB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		3 / 3 CYH B 840
PRO B 845
ASP B 827
 None
 0.96A 3hlwB-5h1uB:
undetectable		 3hlwB-5h1uB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		3 / 3 CYH B 840
PRO B 845
ASP B 827
 None
 0.99A 4pm5A-5h1uB:
undetectable		 4pm5A-5h1uB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		4 / 6 VAL B 928
VAL B 932
TYR B 935
ASN B 980
 6KT  B1101 ( 4.4A)
6KT  B1101 ( 4.9A)
6KT  B1101 (-4.9A)
6KT  B1101 (-3.2A)
 0.43A 5pbeA-5h1uB:
17.8		 5pbeA-5h1uB:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens) 		5 / 10 THR B 947
LEU B 945
SER B 957
VAL B 831
CYH B 852
 None
None
None
None
ZN  B1103 (-2.3A)
 1.45A 6gnfC-5h1uB:
undetectable		 6gnfC-5h1uB:
16.36