SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 7 PRO A 238
VAL A 239
LEU A 216
VAL A 234
 None
 0.58A 1jgsA-5h1yA:
undetectable		 1jgsA-5h1yA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 12 PHE A 235
ILE A 224
GLY A 223
ILE A 207
THR A 395
 None
 0.89A 1nv8B-5h1yA:
3.0		 1nv8B-5h1yA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 12 ILE A 298
LEU A 269
ALA A 270
LEU A 324
PHE A 354
 None
 1.12A 1og5B-5h1yA:
undetectable		 1og5B-5h1yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 12 ILE A 310
LEU A 296
ALA A 295
PRO A 258
LEU A 335
 None
 1.18A 1og5B-5h1yA:
undetectable		 1og5B-5h1yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 12 VAL A 239
TYR A 280
TYR A 279
HIS A 274
ARG A 271
 None
 1.50A 2zthA-5h1yA:
5.0		 2zthA-5h1yA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 11 ALA A 389
LEU A 343
ILE A 361
LEU A 261
PHE A 365
 None
 1.30A 3fl9C-5h1yA:
undetectable		 3fl9C-5h1yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 9 ALA A 389
LEU A 343
ILE A 361
LEU A 261
PHE A 365
 None
 1.31A 3fl9H-5h1yA:
undetectable		 3fl9H-5h1yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 12 LEU A 193
GLY A 195
LEU A 284
MET A 186
MET A 241
 None
 1.33A 3h52C-5h1yA:
undetectable		 3h52C-5h1yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		3 / 3 SER A 363
PHE A 365
LYS A 366
 None
 0.82A 3u88A-5h1yA:
undetectable		 3u88A-5h1yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 11 GLY A 223
ALA A 225
ILE A 207
ILE A 209
ILE A 169
 None
 1.01A 4dt8A-5h1yA:
undetectable		 4dt8A-5h1yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 10 GLY A 223
ALA A 225
ILE A 207
ILE A 209
ILE A 169
 None
 0.94A 4dt8B-5h1yA:
undetectable		 4dt8B-5h1yA:
22.22