SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 6 LEU A  18
ILE A 321
TRP A  24
PRO A  27
 None
 1.23A 1ditH-5h1zA:
undetectable
1ditP-5h1zA:
undetectable		 1ditH-5h1zA:
17.85
1ditP-5h1zA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 GLU A 363
ILE A 286
GLY A 350
PHE A 349
ALA A 323
 None
HEM  A 501 ( 4.6A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.4A)
None
 1.21A 1hvyA-5h1zA:
undetectable		 1hvyA-5h1zA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 6 TYR A  48
VAL A   7
ILE A   8
LEU A  31
 None
 0.91A 1j96A-5h1zA:
undetectable		 1j96A-5h1zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 7 TYR A  48
VAL A   7
ILE A   8
LEU A  31
 None
 0.95A 1j96B-5h1zA:
undetectable		 1j96B-5h1zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 7 GLY A 358
MET A  90
PHE A 235
GLY A 245
 HEM  A 501 (-3.5A)
D12  A 502 (-4.3A)
None
D12  A 502 ( 3.5A)
 0.99A 3ko0M-5h1zA:
0.1
3ko0P-5h1zA:
undetectable		 3ko0M-5h1zA:
13.37
3ko0P-5h1zA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 PHE A 158
LEU A 241
PHE A  91
VAL A 357
PHE A 110
 None
HEM  A 501 (-4.4A)
HEM  A 501 (-4.0A)
HEM  A 501 (-4.9A)
HEM  A 501 (-4.3A)
 1.45A 3nuvA-5h1zA:
undetectable		 3nuvA-5h1zA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 6 ASN A 136
PRO A 138
LEU A 383
ASP A 262
 None
 1.07A 3oi8A-5h1zA:
undetectable		 3oi8A-5h1zA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 7 TYR A  48
VAL A   7
ILE A   8
LEU A  31
 None
 0.94A 4l1wA-5h1zA:
undetectable		 4l1wA-5h1zA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 ILE A 286
ALA A 343
LEU A 271
LEU A 370
ILE A 285
 HEM  A 501 ( 4.6A)
None
None
None
None
 1.05A 4m2xE-5h1zA:
undetectable		 4m2xE-5h1zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 THR A 250
ALA A 362
GLU A 363
LEU A 364
ARG A 355
 HEM  A 501 ( 4.8A)
HEM  A 501 (-3.4A)
None
None
None
 1.30A 4xi3A-5h1zA:
undetectable		 4xi3A-5h1zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 THR A 250
ALA A 362
GLU A 363
LEU A 364
ARG A 355
 HEM  A 501 ( 4.8A)
HEM  A 501 (-3.4A)
None
None
None
 1.28A 4xi3D-5h1zA:
undetectable		 4xi3D-5h1zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		3 / 3 ASP A  12
SER A  50
TYR A  48
 None
 0.77A 5glmA-5h1zA:
undetectable		 5glmA-5h1zA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 6 GLU A 272
ARG A 268
ARG A 406
ARG A 379
 None
 1.18A 5l6eA-5h1zA:
undetectable
5l6eB-5h1zA:
undetectable		 5l6eA-5h1zA:
21.03
5l6eB-5h1zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		4 / 7 LEU A 157
SER A 219
GLU A 114
ASN A 121
 None
 1.05A 5n5dA-5h1zA:
undetectable		 5n5dA-5h1zA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17
(Sphingomonas
sp.
PAMC
26605) 		5 / 12 ILE A  79
ALA A  76
THR A  74
ILE A  73
ALA A  93
 None
None
D12  A 502 (-3.5A)
None
None
 0.97A 5vceA-5h1zA:
28.0		 5vceA-5h1zA:
23.97