SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLN A 504
LEU A 376
LEU A 457
LEU A 455
VAL A 452
 None
 1.24A 2c12C-5h29A:
undetectable		 2c12C-5h29A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 ASN A 453
SER A 454
MET A 359
PHE A 393
 None
 1.25A 2wekA-5h29A:
undetectable		 2wekA-5h29A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 ASN A 453
SER A 454
MET A 359
PHE A 393
 None
 1.21A 2wekB-5h29A:
undetectable		 2wekB-5h29A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 GLY A 445
ILE A 441
PHE A 367
PHE A 397
 None
 1.06A 3ko0B-5h29A:
undetectable
3ko0J-5h29A:
undetectable		 3ko0B-5h29A:
22.12
3ko0J-5h29A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 GLY A 445
ILE A 441
PHE A 367
PHE A 397
 None
 1.03A 3ko0K-5h29A:
undetectable
3ko0S-5h29A:
undetectable		 3ko0K-5h29A:
22.12
3ko0S-5h29A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 6 GLY A 440
THR A 439
LEU A 431
GLU A 514
 None
 0.96A 3ps9A-5h29A:
undetectable		 3ps9A-5h29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 5 ILE A 446
PRO A 447
SER A 428
GLY A 445
 None
 1.13A 3tkdB-5h29A:
undetectable		 3tkdB-5h29A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 5 ILE A 446
PRO A 447
SER A 428
GLY A 445
 None
 1.12A 3tkdA-5h29A:
undetectable		 3tkdA-5h29A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		3 / 3 PHE A 523
VAL A 518
GLU A 486
 TRS  A 602 (-4.7A)
None
None
 0.60A 4fvqA-5h29A:
undetectable		 4fvqA-5h29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 9 PHE A 355
LEU A 363
LEU A 376
VAL A 452
PHE A 443
 None
 1.48A 4wnvB-5h29A:
undetectable		 4wnvB-5h29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 10 SER A 464
GLY A 463
ILE A 441
ALA A 458
LEU A 457
 None
 1.31A 5zjiA-5h29A:
undetectable
5zjiJ-5h29A:
undetectable		 5zjiA-5h29A:
21.65
5zjiJ-5h29A:
20.25