SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 10 GLU A 246
ARG A 249
ARG A 204
LEU A 200
GLU A 197
 None
 1.34A 1cmcA-5h2tA:
undetectable
1cmcB-5h2tA:
undetectable		 1cmcA-5h2tA:
11.02
1cmcB-5h2tA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 9 GLU A 246
ARG A 249
ARG A 204
LEU A 200
GLU A 197
 None
 1.35A 1mj2A-5h2tA:
undetectable		 1mj2A-5h2tA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 9 GLU A 246
ARG A 249
ARG A 204
LEU A 200
GLU A 197
 None
 1.36A 1mj2C-5h2tA:
undetectable		 1mj2C-5h2tA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 9 GLU A 246
ARG A 249
ARG A 204
LEU A 200
GLU A 197
 None
 1.39A 1mjoA-5h2tA:
undetectable		 1mjoA-5h2tA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 9 GLU A 246
ARG A 249
ARG A 204
LEU A 200
GLU A 197
 None
 1.41A 1mjoC-5h2tA:
undetectable		 1mjoC-5h2tA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.91A 1v54N-5h2tA:
undetectable
1v54W-5h2tA:
undetectable		 1v54N-5h2tA:
20.56
1v54W-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 TRP A 557
ARG A 497
PHE A 495
 None
 1.34A 1zeaH-5h2tA:
undetectable
1zeaL-5h2tA:
undetectable		 1zeaH-5h2tA:
15.75
1zeaL-5h2tA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 5 ILE A  62
ILE A 397
MET A 399
LEU A  67
 None
 0.86A 1zgyA-5h2tA:
undetectable		 1zgyA-5h2tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 12 LEU A  32
ASP A  42
PHE A  92
ASP A  38
GLY A  43
 None
 1.08A 1zz1B-5h2tA:
undetectable
1zz1C-5h2tA:
undetectable		 1zz1B-5h2tA:
21.38
1zz1C-5h2tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.07A 2dyrA-5h2tA:
undetectable
2dyrJ-5h2tA:
undetectable		 2dyrA-5h2tA:
20.56
2dyrJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.97A 2dyrN-5h2tA:
undetectable
2dyrW-5h2tA:
undetectable		 2dyrN-5h2tA:
20.56
2dyrW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.04A 2dysN-5h2tA:
undetectable
2dysW-5h2tA:
undetectable		 2dysN-5h2tA:
20.56
2dysW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.08A 2eijA-5h2tA:
undetectable
2eijJ-5h2tA:
undetectable		 2eijA-5h2tA:
20.56
2eijJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.90A 2eijN-5h2tA:
undetectable
2eijW-5h2tA:
undetectable		 2eijN-5h2tA:
20.56
2eijW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.92A 2eikN-5h2tA:
undetectable
2eikW-5h2tA:
undetectable		 2eikN-5h2tA:
20.56
2eikW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 PHE A 425
SER A  37
GLY A  45
THR A  44
 None
 1.19A 2f7fA-5h2tA:
3.1		 2f7fA-5h2tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 LEU A 325
MET A 290
MET A 283
 None
 0.81A 2vavF-5h2tA:
undetectable		 2vavF-5h2tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.07A 3abmA-5h2tA:
undetectable
3abmJ-5h2tA:
undetectable		 3abmA-5h2tA:
20.56
3abmJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.08A 3asnA-5h2tA:
undetectable
3asnJ-5h2tA:
undetectable		 3asnA-5h2tA:
20.56
3asnJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.91A 3asnN-5h2tA:
undetectable
3asnW-5h2tA:
undetectable		 3asnN-5h2tA:
20.56
3asnW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 LEU A 203
TYR A 190
THR A 236
LEU A 240
 None
 1.06A 3asoA-5h2tA:
undetectable
3asoJ-5h2tA:
undetectable		 3asoA-5h2tA:
20.56
3asoJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 ASP A  42
PHE A  92
ASP A  38
GLY A  43
 None
 0.90A 3c0zB-5h2tA:
undetectable		 3c0zB-5h2tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 5 ASP A 115
LEU A 331
ARG A 326
ASP A 217
 None
 1.32A 3kd5E-5h2tA:
0.2		 3kd5E-5h2tA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 5 ASP A 115
LEU A 331
ARG A 412
ASP A 217
 None
 1.47A 3kd5E-5h2tA:
0.2		 3kd5E-5h2tA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 ASN A 357
MET A 354
ILE A 358
ASN A 327
 None
 1.38A 3kp6A-5h2tA:
undetectable
3kp6B-5h2tA:
undetectable		 3kp6A-5h2tA:
12.81
3kp6B-5h2tA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 GLU A 280
VAL A 243
VAL A 219
ALA A 258
 None
 0.94A 3kp6B-5h2tA:
undetectable		 3kp6B-5h2tA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 TYR A  21
VAL A 267
ILE A 315
ARG A 215
 None
 1.09A 3mssB-5h2tA:
undetectable		 3mssB-5h2tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 4 ASP A 329
GLU A 330
GLU A 259
ARG A 215
 None
 1.38A 3o0mA-5h2tA:
undetectable		 3o0mA-5h2tA:
13.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_1
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		6 / 10 TRP A 463
MET A 467
GLU A 531
PHE A 555
TYR A 556
TRP A 557
 None
 0.30A 3zoaA-5h2tA:
63.8		 3zoaA-5h2tA:
71.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 ARG A 512
PHE A 513
PRO A 514
 None
 0.11A 3zoaB-5h2tA:
62.4		 3zoaB-5h2tA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 SER A 306
MET A 309
ILE A 305
PHE A 495
 None
 1.24A 4cx7C-5h2tA:
undetectable
4cx7D-5h2tA:
undetectable		 4cx7C-5h2tA:
21.97
4cx7D-5h2tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 HIS A 184
ASP A 123
SER A 122
ASP A  81
 None
 1.01A 4k0bB-5h2tA:
undetectable		 4k0bB-5h2tA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 HIS A 184
ASP A 123
SER A 122
ASP A  81
 None
 1.01A 4l7iB-5h2tA:
undetectable		 4l7iB-5h2tA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 ASP A 338
ASN A 261
ALA A 260
TYR A 270
 None
 1.20A 4mdaA-5h2tA:
undetectable		 4mdaA-5h2tA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 ASP A 115
TYR A  80
TRP A  66
 None
 1.39A 4p7nA-5h2tA:
15.7		 4p7nA-5h2tA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 GLN A 185
HIS A 184
ARG A  76
 None
 1.12A 4qyqA-5h2tA:
undetectable		 4qyqA-5h2tA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		3 / 3 GLN A 185
HIS A 184
ARG A  76
 None
 1.07A 4qyqB-5h2tA:
undetectable		 4qyqB-5h2tA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.81A 5b1bA-5h2tA:
undetectable
5b1bJ-5h2tA:
undetectable		 5b1bA-5h2tA:
20.56
5b1bJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 ARG A 372
GLY A 458
SER A 459
LEU A 460
 None
 1.30A 5bphD-5h2tA:
undetectable		 5bphD-5h2tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 12 LEU A 519
SER A 306
PHE A 495
TYR A 482
LEU A 505
 None
 1.20A 5czyA-5h2tA:
undetectable		 5czyA-5h2tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 PHE A 214
HIS A 282
LEU A 257
LEU A 216
 None
 1.31A 5dzke-5h2tA:
2.0
5dzks-5h2tA:
undetectable		 5dzke-5h2tA:
15.47
5dzks-5h2tA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 TYR A 392
ASP A 409
ILE A 360
TYR A  80
 None
 1.33A 5igyA-5h2tA:
2.8		 5igyA-5h2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 6 GLY A  35
ASP A  55
ILE A 110
TYR A  29
 None
 1.10A 5iwuA-5h2tA:
3.0		 5iwuA-5h2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.89A 5iy5A-5h2tA:
undetectable
5iy5J-5h2tA:
undetectable		 5iy5A-5h2tA:
20.56
5iy5J-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 12 ASP A 103
GLU A 100
LEU A  57
ARG A  48
LEU A  47
 None
 1.02A 5nd4B-5h2tA:
undetectable		 5nd4B-5h2tA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		6 / 12 TRP A 321
GLY A 322
ILE A 323
PHE A 324
VAL A 267
LEU A 325
 None
 1.14A 5nz0A-5h2tA:
undetectable		 5nz0A-5h2tA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 5 ARG A 363
PHE A 378
LEU A 367
LEU A 460
 None
 1.36A 5veuH-5h2tA:
undetectable		 5veuH-5h2tA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 7 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.78A 5xdqA-5h2tA:
undetectable
5xdqJ-5h2tA:
undetectable		 5xdqA-5h2tA:
20.56
5xdqJ-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 8 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.79A 5zcqN-5h2tA:
undetectable
5zcqW-5h2tA:
undetectable		 5zcqN-5h2tA:
20.56
5zcqW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 5 GLY A  78
ASP A  77
ARG A  76
GLN A  72
 None
 1.42A 5zrfB-5h2tA:
undetectable		 5zrfB-5h2tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		4 / 4 ARG A 362
SER A 410
ASP A 401
ASN A 357
 None
 1.48A 6ag0A-5h2tA:
20.3		 6ag0A-5h2tA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 7 ASP A  42
GLY A  35
PHE A 425
GLY A  45
VAL A  33
 None
 1.13A 6ekzA-5h2tA:
undetectable		 6ekzA-5h2tA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5h2t TREHALOSE SYNTHASE
(Thermomonospora
curvata) 		5 / 10 LEU A  67
VAL A  31
PHE A  36
ALA A 105
LEU A  57
 None
 1.17A 6h1lA-5h2tA:
undetectable		 6h1lA-5h2tA:
23.45