SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 461
LEU A 459
THR A 460
ILE A 517
THR A 516
 None
 1.24A 1pkvA-5h2vA:
undetectable
1pkvB-5h2vA:
undetectable		 1pkvA-5h2vA:
6.24
1pkvB-5h2vA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 461
LEU A 459
THR A 460
ILE A 517
THR A 516
 None
 1.25A 1pkvA-5h2vA:
undetectable
1pkvB-5h2vA:
undetectable		 1pkvA-5h2vA:
6.24
1pkvB-5h2vA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 564
SER A 605
VAL A 542
LEU A 502
LEU A 514
 None
 1.17A 1s19A-5h2vA:
undetectable		 1s19A-5h2vA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 137
GLY A 109
PHE A 110
SER A 112
 None
 1.21A 2a3cA-5h2vA:
undetectable		 2a3cA-5h2vA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 137
GLY A 109
PHE A 110
SER A 112
 None
 1.23A 2a3cB-5h2vA:
undetectable		 2a3cB-5h2vA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 394
LEU A 364
LEU A 352
LEU A 372
PRO A 367
 None
 1.10A 2qxsA-5h2vA:
undetectable		 2qxsA-5h2vA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 633
LEU A 629
ALA A 632
LEU A 628
 None
 1.43A 2roxA-5h2vA:
undetectable		 2roxA-5h2vA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 305
ILE A 265
TYR A 371
ASP A 269
 None
 1.05A 2v57A-5h2vA:
undetectable		 2v57A-5h2vA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 305
ILE A 265
TYR A 371
ASP A 269
 None
 1.05A 2v57C-5h2vA:
1.9		 2v57C-5h2vA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 172
ILE A 170
TYR A 168
PRO A 167
VAL A 166
 None
 1.38A 2x08A-5h2vA:
undetectable		 2x08A-5h2vA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 514
ILE A 517
MET A 536
VAL A 624
 None
 1.10A 2ygoA-5h2vA:
undetectable		 2ygoA-5h2vA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		3 / 3 MET A 389
GLU A 342
ASP A 325
 None
 1.12A 3a25A-5h2vA:
undetectable		 3a25A-5h2vA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 686
LEU A 728
ALA A 705
ILE A 704
LEU A 629
 None
 1.01A 3fl9A-5h2vA:
undetectable		 3fl9A-5h2vA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 253
LEU A 220
ILE A 264
LEU A 288
PHE A 292
 None
 1.32A 3fl9D-5h2vA:
undetectable		 3fl9D-5h2vA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 909
GLY A 925
ALA A 970
ILE A 940
THR A 945
 None
 1.02A 3gguB-5h2vA:
undetectable		 3gguB-5h2vA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
GLY A 217
LEU A 219
TYR A 204
PHE A 186
 None
 1.02A 3gwwA-5h2vA:
undetectable		 3gwwA-5h2vA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 GLU A1049
VAL A1053
GLN A1010
ALA A1005
 None
 1.02A 3kp6B-5h2vA:
undetectable		 3kp6B-5h2vA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 996
LEU A1012
SER A1006
THR A1052
 None
 0.98A 3lm8A-5h2vA:
undetectable
3lm8C-5h2vA:
undetectable		 3lm8A-5h2vA:
12.63
3lm8C-5h2vA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 819
ILE A 178
LEU A 216
PHE A 205
 None
 1.20A 3ls4L-5h2vA:
undetectable		 3ls4L-5h2vA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 887
ARG A 917
ILE A 949
ALA A 928
TYR A 935
 None
 1.19A 3ohtA-5h2vA:
undetectable
3ohtB-5h2vA:
undetectable		 3ohtA-5h2vA:
16.73
3ohtB-5h2vA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 202
ALA A 200
SER A 226
LEU A 227
THR A 164
 None
 1.16A 3qfxA-5h2vA:
undetectable		 3qfxA-5h2vA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 202
ALA A 200
SER A 226
LEU A 227
THR A 164
 None
 1.18A 3qfxB-5h2vA:
undetectable		 3qfxB-5h2vA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 307
TYR A 371
LEU A 372
MET A 375
ALA A 386
 None
 1.23A 3t7vA-5h2vA:
undetectable		 3t7vA-5h2vA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  74
GLU A 642
GLU A  31
PHE A  19
VAL A  69
 None
 1.30A 3ua5B-5h2vA:
undetectable		 3ua5B-5h2vA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 359
GLN A 308
PRO A 367
TYR A 363
 None
 1.27A 3vkxA-5h2vA:
undetectable		 3vkxA-5h2vA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 426
HIS A 470
ARG A 466
 None
 0.80A 4e7bC-5h2vA:
undetectable		 4e7bC-5h2vA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 495
ILE A 517
ALA A 518
ALA A 567
GLY A 569
 None
 0.77A 4enhA-5h2vA:
undetectable		 4enhA-5h2vA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 223
VAL A 198
ALA A 238
PHE A 230
SER A 226
 None
 1.48A 4evrA-5h2vA:
undetectable		 4evrA-5h2vA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 475
LEU A 495
GLN A 444
GLU A 522
 None
 1.14A 4i41A-5h2vA:
undetectable		 4i41A-5h2vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 887
ALA A 928
ILE A 974
LEU A 909
ILE A 923
 None
 1.10A 4km0B-5h2vA:
undetectable		 4km0B-5h2vA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 909
GLY A 925
ALA A 970
ILE A 940
THR A 945
 None
 1.14A 4njtD-5h2vA:
undetectable		 4njtD-5h2vA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 451
THR A 516
SER A 479
LEU A 501
LEU A 459
 None
 1.29A 4qztA-5h2vA:
undetectable		 4qztA-5h2vA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  51
LEU A  47
LEU A  70
ALA A  30
LEU A  34
 None
 1.03A 4wg0F-5h2vA:
undetectable
4wg0G-5h2vA:
undetectable
4wg0H-5h2vA:
undetectable		 4wg0F-5h2vA:
1.22
4wg0G-5h2vA:
1.22
4wg0H-5h2vA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  51
LEU A  47
LEU A  70
ALA A  30
LEU A  34
 None
 1.03A 4wg0H-5h2vA:
undetectable
4wg0I-5h2vA:
undetectable
4wg0J-5h2vA:
undetectable		 4wg0H-5h2vA:
1.22
4wg0I-5h2vA:
1.22
4wg0J-5h2vA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  30
LEU A  34
LEU A  70
LEU A  51
LEU A  47
 None
 1.00A 4wg0K-5h2vA:
undetectable
4wg0L-5h2vA:
undetectable
4wg0M-5h2vA:
undetectable		 4wg0K-5h2vA:
1.22
4wg0L-5h2vA:
1.22
4wg0M-5h2vA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 372
LEU A 391
SER A 392
VAL A 424
 None
 1.28A 5a6iA-5h2vA:
undetectable		 5a6iA-5h2vA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 538
LEU A 498
LEU A 502
LEU A 514
ALA A 513
 None
 0.91A 5dqfA-5h2vA:
undetectable		 5dqfA-5h2vA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 410
ILE A 414
PRO A 453
LEU A 455
 None
 1.00A 5eb3A-5h2vA:
undetectable		 5eb3A-5h2vA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 131
LEU A 134
LEU A  99
ALA A 127
ARG A 103
 None
 1.17A 5g44A-5h2vA:
undetectable		 5g44A-5h2vA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 890
LEU A 854
VAL A 775
GLY A 851
GLN A 893
 None
 1.24A 5hg0A-5h2vA:
undetectable		 5hg0A-5h2vA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 916
ASP A 913
ARG A 915
LEU A 835
 None
 1.03A 5hwaA-5h2vA:
undetectable		 5hwaA-5h2vA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 396
ALA A 473
SER A 440
ILE A 443
PHE A 439
 None
 1.17A 5iwuA-5h2vA:
undetectable		 5iwuA-5h2vA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 279
ARG A 282
GLU A 278
 None
 0.89A 5j6hA-5h2vA:
undetectable		 5j6hA-5h2vA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 8 THR A 995
SER A 955
ALA A 967
SER A 921
 None
 1.01A 5l5fY-5h2vA:
undetectable
5l5fZ-5h2vA:
undetectable		 5l5fY-5h2vA:
11.18
5l5fZ-5h2vA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 728
ILE A 727
SER A 773
LEU A 628
ILE A 704
 None
 1.12A 5m24A-5h2vA:
undetectable		 5m24A-5h2vA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 140
LEU A 169
LEU A 163
ALA A 127
GLU A 128
 None
 1.14A 5v0vA-5h2vA:
2.9		 5v0vA-5h2vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 169
LEU A 144
ILE A 126
ALA A 127
GLU A 128
 None
 0.95A 5v0vA-5h2vA:
2.9		 5v0vA-5h2vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 727
LEU A 754
ALA A 750
LEU A 706
GLU A 742
 None
 1.25A 5y7pG-5h2vA:
undetectable		 5y7pG-5h2vA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 406
LEU A 410
ILE A 486
ALA A 454
 None
 0.78A 6b5vA-5h2vA:
undetectable
6b5vC-5h2vA:
undetectable		 6b5vA-5h2vA:
7.15
6b5vC-5h2vA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 406
LEU A 410
ILE A 486
ALA A 454
 None
 0.79A 6b5vC-5h2vA:
undetectable
6b5vD-5h2vA:
0.2		 6b5vC-5h2vA:
7.15
6b5vD-5h2vA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 454
ILE A 406
LEU A 410
ILE A 486
 None
 0.77A 6b5vB-5h2vA:
undetectable
6b5vD-5h2vA:
0.2		 6b5vB-5h2vA:
7.15
6b5vD-5h2vA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 364
THR A 314
LEU A 315
ALA A 390
TYR A 371
 None
 1.16A 6djzC-5h2vA:
undetectable		 6djzC-5h2vA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 7 ALA A   3
GLU A  53
ILE A 102
ILE A  94
 None
 0.86A 6fbnA-5h2vA:
undetectable		 6fbnA-5h2vA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 633
LEU A 629
ALA A 632
LEU A 628
 None
 1.47A 6gnrA-5h2vA:
undetectable		 6gnrA-5h2vA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5h2v IMPORTIN SUBUNIT
BETA-3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 633
LEU A 629
ALA A 632
LEU A 628
 None
 1.46A 6gnrB-5h2vA:
undetectable		 6gnrB-5h2vA:
9.03