SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 11 ALA C 154
THR C 131
LEU C  53
LEU C 124
GLY C 123
 PX4  C 303 ( 3.9A)
PX4  C 303 ( 4.8A)
None
None
None
 1.06A 1b02A-5h35C:
undetectable		 1b02A-5h35C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 PHE C  16
THR C 103
ILE C  11
VAL C  77
SER C  74
 None
 1.00A 1sg9B-5h35C:
2.3		 1sg9B-5h35C:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		4 / 5 ALA C 112
TYR C 113
ALA C 126
TYR C 164
 None
GOL  C 302 (-4.1A)
None
None
 1.02A 1xl6A-5h35C:
undetectable
1xl6B-5h35C:
2.5		 1xl6A-5h35C:
22.88
1xl6B-5h35C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.15A 2bm9A-5h35C:
undetectable		 2bm9A-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.19A 2bm9D-5h35C:
undetectable		 2bm9D-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 140
LEU C  37
GLY C 133
SER C  19
ALA C  44
 None
 0.99A 2br4A-5h35C:
undetectable		 2br4A-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.12A 2br4D-5h35C:
undetectable		 2br4D-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 140
LEU C  37
GLY C 133
SER C  19
ALA C  44
 None
 1.01A 2br4D-5h35C:
undetectable		 2br4D-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.10A 2br4F-5h35C:
undetectable		 2br4F-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 2f16K-5h35C:
undetectable
2f16L-5h35C:
undetectable		 2f16K-5h35C:
22.94
2f16L-5h35C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 2f16Y-5h35C:
undetectable
2f16Z-5h35C:
undetectable		 2f16Y-5h35C:
22.94
2f16Z-5h35C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 8 GLY C 132
GLY C 133
ALA C  44
PHE C 104
PHE C  16
 PX4  C 303 ( 4.6A)
None
None
None
None
 1.31A 2ha4A-5h35C:
undetectable		 2ha4A-5h35C:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ARG C 187
SER C 160
PHE C  16
LEU C  22
GLY C 133
 None
 1.36A 2v0mA-5h35C:
undetectable		 2v0mA-5h35C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ARG C 187
SER C 160
PHE C  16
LEU C  22
GLY C 134
 None
 1.32A 2v0mA-5h35C:
undetectable		 2v0mA-5h35C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 PHE C  16
ALA C  44
GLY C  45
GLY C 132
ILE C 136
 None
None
None
PX4  C 303 ( 4.6A)
None
 1.19A 2v7bB-5h35C:
undetectable		 2v7bB-5h35C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		4 / 4 ALA C 112
TYR C 113
ALA C 126
TYR C 164
 None
GOL  C 302 (-4.1A)
None
None
 1.04A 2wlkA-5h35C:
2.3
2wlkB-5h35C:
2.0		 2wlkA-5h35C:
22.88
2wlkB-5h35C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		4 / 6 GLY C 133
SER C  19
ILE C 136
ILE C  48
 None
 0.75A 3a7eA-5h35C:
undetectable		 3a7eA-5h35C:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 PHE C  16
GLY C  20
GLY C  38
ASP C 138
SER C  19
 None
 1.36A 3dlcA-5h35C:
undetectable		 3dlcA-5h35C:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 GLY C  20
SER C  21
SER C  74
GLY C  38
THR C  41
 None
 1.26A 4lb0A-5h35C:
undetectable		 4lb0A-5h35C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		6 / 12 GLY C 133
LEU C 101
MET C 146
LEU C 140
GLY C  38
ILE C  40
 None
 1.29A 5d4uD-5h35C:
undetectable		 5d4uD-5h35C:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 12 SER C 114
LEU C   8
THR C 103
THR C 106
ALA C 109
 None
 1.18A 5dsgB-5h35C:
3.0		 5dsgB-5h35C:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.06A 5l5zK-5h35C:
undetectable
5l5zL-5h35C:
undetectable		 5l5zK-5h35C:
25.10
5l5zL-5h35C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 5l5zY-5h35C:
undetectable
5l5zZ-5h35C:
undetectable		 5l5zY-5h35C:
25.10
5l5zZ-5h35C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		4 / 4 LEU C 181
GLY C 182
SER C 183
SER C 102
 None
 1.18A 5uunA-5h35C:
2.3		 5uunA-5h35C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		4 / 4 LEU C 181
GLY C 182
SER C 183
SER C 102
 None
 1.19A 5uunB-5h35C:
undetectable		 5uunB-5h35C:
21.74