SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 7 HIS A  52
LEU A  98
THR A  99
THR A 100
 None
 0.69A 1am6A-5h3aA:
undetectable		 1am6A-5h3aA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.07A 1axwA-5h3aA:
36.3		 1axwA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.89A 1axwB-5h3aA:
36.5		 1axwB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.99A 1axwB-5h3aA:
36.5		 1axwB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 12 PHE A 104
GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.76A 1hvyA-5h3aA:
21.0		 1hvyA-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.63A 1hvyA-5h3aA:
21.0		 1hvyA-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.78A 1hvyB-5h3aA:
43.0		 1hvyB-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.64A 1hvyB-5h3aA:
43.0		 1hvyB-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 11 PHE A 104
GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.62A 1hvyC-5h3aA:
21.3		 1hvyC-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.62A 1hvyC-5h3aA:
21.3		 1hvyC-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASN A 136
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.73A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.56A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
TRP A 133
ASN A 136
LEU A 216
PHE A 249
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
None
D16  A 401 (-3.4A)
 0.69A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 9 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.35A 1i00A-5h3aA:
21.2		 1i00A-5h3aA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.21A 1i00B-5h3aA:
21.0		 1i00B-5h3aA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 9 PHE A 104
TRP A 133
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.90A 1i00B-5h3aA:
21.0		 1i00B-5h3aA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
ASN A 136
GLY A 246
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.17A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.95A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.86A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.96A 1ju6C-5h3aA:
42.3		 1ju6C-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.66A 1ju6D-5h3aA:
42.3		 1ju6D-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujA-5h3aA:
41.6		 1jujA-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujB-5h3aA:
41.5		 1jujB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujC-5h3aA:
41.6		 1jujC-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujD-5h3aA:
41.6		 1jujD-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.26A 1rtsA-5h3aA:
43.7		 1rtsA-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.21A 1rtsB-5h3aA:
43.8		 1rtsB-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.08A 1tlsA-5h3aA:
36.3		 1tlsA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.09A 1tlsB-5h3aA:
36.5		 1tlsB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.06A 1tlsB-5h3aA:
36.5		 1tlsB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.08A 1tsnA-5h3aA:
36.3		 1tsnA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.01A 1tsnA-5h3aA:
36.3		 1tsnA-5h3aA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 PHE A 320
LEU A 256
LEU A 112
GLU A 313
LEU A 116
 None
 1.19A 2bxfA-5h3aA:
undetectable		 2bxfA-5h3aA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.77A 2kceA-5h3aA:
36.3		 2kceA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.28A 2kceA-5h3aA:
36.3		 2kceA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.85A 2kceB-5h3aA:
36.6		 2kceB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.23A 2tsrA-5h3aA:
43.9		 2tsrA-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 2tsrC-5h3aA:
43.9		 2tsrC-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
GLU A 111
ILE A 132
TRP A 133
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
 0.75A 2tsrC-5h3aA:
43.9		 2tsrC-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.31A 2tsrD-5h3aA:
20.7		 2tsrD-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
TYR A 282
THR A 330
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
None
 0.63A 2tsrD-5h3aA:
20.7		 2tsrD-5h3aA:
70.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 322
PHE A  95
VAL A 103
ILE A 251
SER A 255
 None
 1.44A 2xpwA-5h3aA:
undetectable		 2xpwA-5h3aA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 HIS A  52
ILE A 251
LEU A  98
THR A  99
THR A 100
 None
 1.07A 3fw3B-5h3aA:
undetectable		 3fw3B-5h3aA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.95A 3k2hA-5h3aA:
19.3		 3k2hA-5h3aA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.96A 3k2hB-5h3aA:
20.4		 3k2hB-5h3aA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
GLY A 246
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
 0.81A 3k2hB-5h3aA:
20.4		 3k2hB-5h3aA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.65A 3nrrA-5h3aA:
undetectable		 3nrrA-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASN A 136
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.88A 3nrrB-5h3aA:
undetectable		 3nrrB-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.64A 3nrrB-5h3aA:
undetectable		 3nrrB-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
HIS A 220
GLY A 246
ASN A 250
TYR A 282
 None
UMP  A 402 (-3.9A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.83A 3uwlD-5h3aA:
34.8		 3uwlD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 TRP A 133
LEU A 216
HIS A 220
GLY A 246
ASN A 250
 None
None
UMP  A 402 (-3.9A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 3uwlD-5h3aA:
34.8		 3uwlD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.40A 4eb4A-5h3aA:
42.5		 4eb4A-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.45A 4eb4B-5h3aA:
42.2		 4eb4B-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.22A 4eb4C-5h3aA:
43.2		 4eb4C-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.25A 4eb4D-5h3aA:
43.1		 4eb4D-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 PHE A 104
ILE A 132
TRP A 133
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.71A 4eb4D-5h3aA:
43.1		 4eb4D-5h3aA:
71.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 LEU A  61
LEU A  58
GLU A  54
TYR A  57
 None
 1.21A 4f3tA-5h3aA:
undetectable		 4f3tA-5h3aA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ARG A 164
GLY A 160
SER A 311
VAL A 264
VAL A 189
 None
 1.34A 4ffwA-5h3aA:
undetectable		 4ffwA-5h3aA:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.77A 4fogA-5h3aA:
35.9		 4fogA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.04A 4fogA-5h3aA:
35.9		 4fogA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.10A 4fogC-5h3aA:
35.9		 4fogC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.70A 4fogC-5h3aA:
35.9		 4fogC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.88A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.81A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.78A 4foxA-5h3aA:
36.1		 4foxA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.18A 4foxA-5h3aA:
36.1		 4foxA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.75A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
UMP  A 402 (-4.5A)
 0.75A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.20A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 GLU A 111
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.82A 4foxC-5h3aA:
36.1		 4foxC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.63A 4foxD-5h3aA:
35.8		 4foxD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.64A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.69A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.20A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.90A 4foxF-5h3aA:
36.0		 4foxF-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.25A 4foxF-5h3aA:
36.0		 4foxF-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.78A 4foxG-5h3aA:
36.0		 4foxG-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.23A 4foxG-5h3aA:
36.0		 4foxG-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.74A 4foxH-5h3aA:
35.7		 4foxH-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.02A 4foxH-5h3aA:
35.7		 4foxH-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.34A 4iqqB-5h3aA:
41.5		 4iqqB-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.36A 4iqqC-5h3aA:
42.1		 4iqqC-5h3aA:
58.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A  61
LEU A  58
GLU A  54
LEU A  98
ILE A 281
 None
 1.10A 4j24A-5h3aA:
undetectable		 4j24A-5h3aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A  61
LEU A  58
GLU A  54
LEU A  98
ILE A 281
 None
 1.14A 4j24B-5h3aA:
undetectable		 4j24B-5h3aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 ARG A 123
ASP A 121
ASP A 172
ARG A 151
 None
 1.28A 4kcnA-5h3aA:
undetectable		 4kcnA-5h3aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 ARG A 123
ASP A 121
ASP A 172
ARG A 151
 None
 1.29A 4kcnB-5h3aA:
undetectable		 4kcnB-5h3aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 116
VAL A 108
GLY A 107
SER A 253
LEU A 256
 None
 1.44A 4ot2A-5h3aA:
undetectable		 4ot2A-5h3aA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.99A 5fctA-5h3aA:
42.8		 5fctA-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.98A 5fctA-5h3aA:
42.8		 5fctA-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
CYH A 219
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
UMP  A 402 (-3.4A)
UMP  A 402 (-4.5A)
 0.73A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
LEU A 216
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
UMP  A 402 (-4.5A)
 0.83A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
TRP A 133
LEU A 216
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
 0.70A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.89A 5j7wD-5h3aA:
35.3		 5j7wD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 1.08A 5j7wD-5h3aA:
35.3		 5j7wD-5h3aA:
45.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 7 HIS A  52
LEU A  98
THR A  99
THR A 100
 None
 0.91A 5m78A-5h3aA:
undetectable		 5m78A-5h3aA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.22A 5nooA-5h3aA:
42.7		 5nooA-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.28A 5nooB-5h3aA:
42.2		 5nooB-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.15A 5nooC-5h3aA:
41.9		 5nooC-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
THR A 330
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
None
 0.58A 5x5qB-5h3aA:
43.6		 5x5qB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.74A 5x5qB-5h3aA:
43.6		 5x5qB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 7 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.26A 5x5qC-5h3aA:
43.8		 5x5qC-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 5x5qD-5h3aA:
43.7		 5x5qD-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 5x5qF-5h3aA:
43.5		 5x5qF-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.32A 5x66A-5h3aA:
44.1
5x66B-5h3aA:
29.5		 5x66A-5h3aA:
71.73
5x66B-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.34A 5x66C-5h3aA:
44.0		 5x66C-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.35A 5x66D-5h3aA:
43.5		 5x66D-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
THR A 330
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
None
 0.47A 5x66F-5h3aA:
43.5		 5x66F-5h3aA:
71.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 GLY A 156
THR A 120
TYR A 177
TYR A 170
 None
 1.27A 6ag0A-5h3aA:
undetectable		 6ag0A-5h3aA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 GLN A  56
LEU A  98
ARG A 295
PRO A 297
 None
 1.15A 6brdB-5h3aA:
undetectable		 6brdB-5h3aA:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
ASN A 250
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.95A 6qxsB-5h3aA:
34.8		 6qxsB-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.68A 6qxsB-5h3aA:
34.8		 6qxsB-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.55A 6qxsD-5h3aA:
34.7		 6qxsD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.62A 6qyaD-5h3aA:
34.5		 6qyaD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
HIS A 220
ASN A 250
 D16  A 401 ( 4.0A)
None
None
UMP  A 402 (-3.9A)
UMP  A 402 (-3.2A)
 0.78A 6qyaD-5h3aA:
34.5		 6qyaD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
TRP A 133
ASN A 136
LEU A 216
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.10A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.18A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 PHE A 104
ASP A 242
GLY A 246
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.60A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 1.18A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
ASN A 136
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.22A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.24A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eB-5h3aA:
42.1		 6r2eB-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 6r2eB-5h3aA:
42.1		 6r2eB-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eC-5h3aA:
42.5		 6r2eC-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eC-5h3aA:
42.5		 6r2eC-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.79A 6r2eD-5h3aA:
42.2		 6r2eD-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eD-5h3aA:
42.2		 6r2eD-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.13A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
TYR A 159
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.32A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
TYR A 159
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.93A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.78A 6r2eF-5h3aA:
42.3		 6r2eF-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.80A 6r2eF-5h3aA:
42.3		 6r2eF-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 11 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.11A 6r2eG-5h3aA:
42.6		 6r2eG-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.26A 6r2eG-5h3aA:
42.6		 6r2eG-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
TYR A 159
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.89A 6r2eH-5h3aA:
42.3		 6r2eH-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
TYR A 159
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.87A 6r2eH-5h3aA:
42.3		 6r2eH-5h3aA:
71.38