SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 HIS A 216
HIS A 248
PHE A 160
ALA A 123
ASP A 220
 None
F50  A 301 (-4.0A)
None
None
None
 1.19A 1a4lA-5h3hA:
undetectable		 1a4lA-5h3hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 HIS A 216
HIS A 248
PHE A 160
ALA A 123
ASP A 220
 None
F50  A 301 (-4.0A)
None
None
None
 1.22A 1a4lC-5h3hA:
undetectable		 1a4lC-5h3hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 TYR A  71
LEU A 205
THR A 128
ARG A 130
 None
 1.27A 1i2wA-5h3hA:
undetectable		 1i2wA-5h3hA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 6 SER A  62
ASN A  33
LEU A 180
ASP A 183
 None
 0.89A 1mxdA-5h3hA:
undetectable		 1mxdA-5h3hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 8 SER A  62
ASN A  33
LEU A 180
ASP A 183
 None
 0.96A 1mxgA-5h3hA:
undetectable		 1mxgA-5h3hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 GLU A 254
ILE A 214
GLY A 217
SER A 246
PHE A 165
 None
 1.42A 1q8jA-5h3hA:
undetectable		 1q8jA-5h3hA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		3 / 3 TRP A 176
GLU A  38
TYR A  39
 None
 0.91A 2a3aA-5h3hA:
undetectable		 2a3aA-5h3hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 7 GLY A  29
SER A  96
PHE A 160
HIS A 248
 F50  A 301 (-3.4A)
F50  A 301 (-2.4A)
None
F50  A 301 (-4.0A)
 1.15A 2ackA-5h3hA:
2.1		 2ackA-5h3hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 ASP A 253
GLY A 247
ASP A 220
PHE A 164
GLY A 161
 None
None
None
F50  A 301 (-4.7A)
None
 1.11A 2fqyA-5h3hA:
3.2		 2fqyA-5h3hA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 ALA A  64
GLY A 188
ASN A  33
MET A  74
LEU A  27
 None
 0.99A 2hw2A-5h3hA:
undetectable		 2hw2A-5h3hA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 6 ARG A  57
ASP A  70
THR A  73
ASP A   9
 None
 0.85A 2j2pE-5h3hA:
undetectable
2j2pF-5h3hA:
undetectable		 2j2pE-5h3hA:
21.48
2j2pF-5h3hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 HIS A 248
ASP A 220
GLY A  29
SER A  96
ALA A 120
 F50  A 301 (-4.0A)
None
F50  A 301 (-3.4A)
F50  A 301 (-2.4A)
None
 1.28A 3sueD-5h3hA:
undetectable		 3sueD-5h3hA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 HIS A 248
GLY A 249
LEU A 119
ALA A 123
ALA A 124
 F50  A 301 (-4.0A)
None
None
None
None
 1.05A 3sufA-5h3hA:
undetectable		 3sufA-5h3hA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 11 MET A  36
PHE A  37
LEU A 262
ILE A 235
LEU A 205
 None
 1.09A 4kt0A-5h3hA:
undetectable
4kt0J-5h3hA:
undetectable		 4kt0A-5h3hA:
15.92
4kt0J-5h3hA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.44A 4olbA-5h3hA:
2.1		 4olbA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 HIS A 216
PHE A 251
ASP A 220
HIS A 248
GLY A 247
 None
None
None
F50  A 301 (-4.0A)
None
 1.30A 4qa2A-5h3hA:
2.2		 4qa2A-5h3hA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		3 / 3 ASP A 220
HIS A 216
LYS A 218
 None
 0.94A 4qzuD-5h3hA:
undetectable		 4qzuD-5h3hA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 9 LEU A  27
LEU A 262
THR A  91
LEU A  92
ILE A 118
 None
 1.37A 4ubsA-5h3hA:
undetectable		 4ubsA-5h3hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		3 / 3 MET A 137
GLU A 141
LEU A 145
 None
 0.49A 4v2oB-5h3hA:
1.1		 4v2oB-5h3hA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 ILE A  78
VAL A  54
ILE A  52
VAL A  81
 None
 0.75A 4xdtA-5h3hA:
undetectable		 4xdtA-5h3hA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 6 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.37A 4z4cA-5h3hA:
3.1		 4z4cA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.48A 4z4dA-5h3hA:
2.6		 4z4dA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 7 HIS A 248
CYH A 223
GLY A 247
HIS A 216
 F50  A 301 (-4.0A)
F50  A 301 ( 4.9A)
None
None
 1.27A 5a5zC-5h3hA:
undetectable		 5a5zC-5h3hA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		6 / 12 VAL A  81
ILE A  13
ALA A   7
VAL A  54
GLY A  53
ILE A  52
 None
 1.41A 5j2tC-5h3hA:
4.4		 5j2tC-5h3hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 7 LEU A  44
TYR A  51
ASP A  55
LEU A 262
 None
 0.98A 5jq7B-5h3hA:
undetectable		 5jq7B-5h3hA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		5 / 12 LEU A 262
ILE A 118
GLY A  94
VAL A  90
LEU A 205
 None
 0.99A 5ycnA-5h3hA:
undetectable		 5ycnA-5h3hA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 HIS A 248
ALA A 123
SER A  96
GLY A  29
 F50  A 301 (-4.0A)
None
F50  A 301 (-2.4A)
F50  A 301 (-3.4A)
 1.27A 5yodB-5h3hA:
undetectable		 5yodB-5h3hA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 SER A 185
TYR A  59
GLY A  58
TYR A  69
 None
 0.83A 5yodH-5h3hA:
undetectable		 5yodH-5h3hA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		4 / 5 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.37A 6cbdA-5h3hA:
3.7		 6cbdA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN
(Exiguobacterium
antarcticum) 		3 / 3 HIS A 109
ASN A 108
LEU A 107
 None
 0.90A 6f7lB-5h3hA:
undetectable		 6f7lB-5h3hA:
21.90