SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.29A 1iiuA-5h3kA:
undetectable		 1iiuA-5h3kA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.12A 1iiuA-5h3kA:
undetectable		 1iiuA-5h3kA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.30A 1kt4A-5h3kA:
undetectable		 1kt4A-5h3kA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.03A 1kt4A-5h3kA:
undetectable		 1kt4A-5h3kA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.30A 1kt5A-5h3kA:
undetectable		 1kt5A-5h3kA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.07A 1kt5A-5h3kA:
undetectable		 1kt5A-5h3kA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 377
PHE A 495
ASN A 497
ASN A 374
 None
 0.94A 1oniG-5h3kA:
undetectable
1oniI-5h3kA:
undetectable		 1oniG-5h3kA:
14.59
1oniI-5h3kA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 533
LEU A 574
GLY A 502
PHE A 342
GLY A 341
 None
 1.09A 1ru9H-5h3kA:
undetectable
1ru9L-5h3kA:
2.7		 1ru9H-5h3kA:
16.16
1ru9L-5h3kA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A 520
ARG A 531
ASN A 575
GLN A 527
 None
 1.38A 1t9uA-5h3kA:
undetectable		 1t9uA-5h3kA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A  58
ILE A  56
LEU A  89
ASN A 191
VAL A 127
 None
 1.18A 2nnhB-5h3kA:
undetectable		 2nnhB-5h3kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A 366
ILE A 365
GLY A 352
GLY A 500
SER A 521
 None
 1.12A 2qmmA-5h3kA:
undetectable		 2qmmA-5h3kA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 VAL A 238
TYR A 227
VAL A 156
SER A 194
 None
 1.15A 2x45A-5h3kA:
undetectable		 2x45A-5h3kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 VAL A 238
TYR A 227
VAL A 156
SER A 194
 None
 1.18A 2x45B-5h3kA:
undetectable		 2x45B-5h3kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 ARG A 284
GLN A 292
PHE A 293
LEU A 568
 None
 1.27A 3ablC-5h3kA:
undetectable
3ablJ-5h3kA:
undetectable		 3ablC-5h3kA:
18.17
3ablJ-5h3kA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 151
ALA A 192
VAL A 156
LEU A 229
PHE A 107
 None
 1.24A 3bszE-5h3kA:
undetectable		 3bszE-5h3kA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 PRO A 421
ILE A 456
PRO A 455
TYR A 423
 None
 1.37A 3d9lA-5h3kA:
undetectable
3d9lY-5h3kA:
undetectable		 3d9lA-5h3kA:
11.70
3d9lY-5h3kA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 151
ALA A 192
GLN A 152
VAL A 250
ILE A 261
 None
 0.96A 3e00A-5h3kA:
undetectable		 3e00A-5h3kA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 151
ALA A 192
GLN A 152
VAL A 250
ILE A 261
 None
 1.08A 3falA-5h3kA:
undetectable		 3falA-5h3kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		6 / 12 GLY A 341
LEU A 351
MET A 313
SER A 405
GLY A 363
SER A 362
 None
 1.49A 3g2oB-5h3kA:
undetectable		 3g2oB-5h3kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ARG A 528
SER A 557
LEU A 558
THR A 516
ALA A 515
 None
 0.99A 3kw2A-5h3kA:
undetectable		 3kw2A-5h3kA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 506
PHE A 520
SER A 521
LEU A 558
ALA A 515
 None
 1.25A 3lw5B-5h3kA:
undetectable		 3lw5B-5h3kA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 340
GLY A 341
ALA A 323
ASN A 339
LEU A 584
 None
 1.07A 3rc0B-5h3kA:
undetectable		 3rc0B-5h3kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 501
VAL A 354
GLY A 498
ALA A 372
LEU A 576
 None
 1.02A 3sm2B-5h3kA:
undetectable		 3sm2B-5h3kA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 SER A 129
LEU A 114
THR A 128
ARG A  77
 None
 1.39A 3thrB-5h3kA:
undetectable		 3thrB-5h3kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 352
GLY A 363
LEU A 403
ALA A 501
ASN A 603
 None
 1.01A 3vywB-5h3kA:
undetectable		 3vywB-5h3kA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 520
PHE A 524
LEU A 505
LEU A 558
 None
 0.93A 4ejgB-5h3kA:
undetectable		 4ejgB-5h3kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 502
ARG A 368
PHE A 520
GLY A 341
ASP A 577
 None
 1.31A 4h2fA-5h3kA:
undetectable		 4h2fA-5h3kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 353
GLY A 502
GLY A 369
LEU A 505
LEU A 504
 None
 0.90A 4lg1A-5h3kA:
undetectable		 4lg1A-5h3kA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 353
GLY A 502
GLY A 369
LEU A 505
LEU A 504
 None
 0.90A 4lg1B-5h3kA:
undetectable		 4lg1B-5h3kA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 353
GLY A 502
GLY A 369
LEU A 505
LEU A 504
 None
 0.94A 4lg1C-5h3kA:
undetectable		 4lg1C-5h3kA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  81
ALA A  66
PHE A 118
ALA A 120
VAL A 609
 None
 1.41A 4ryaA-5h3kA:
undetectable		 4ryaA-5h3kA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 123
ASP A  82
TRP A 275
 None
 1.22A 4xdqA-5h3kA:
undetectable		 4xdqA-5h3kA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLN A 409
SER A 427
ASP A 428
GLU A 430
LEU A 349
 None
 1.37A 5jh7D-5h3kA:
undetectable		 5jh7D-5h3kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 573
ILE A 338
LEU A 576
ILE A 605
ALA A 570
 None
 0.94A 5nunA-5h3kA:
1.8		 5nunA-5h3kA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 542
ILE A 534
ALA A 340
ILE A 328
ALA A 329
 None
 1.10A 5vceA-5h3kA:
undetectable		 5vceA-5h3kA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE A 338
ALA A 546
ASP A 592
LEU A 591
ILE A 279
 None
 1.49A 5z6lA-5h3kA:
undetectable		 5z6lA-5h3kA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  93
GLY A  84
GLY A  81
GLY A  79
ARG A 117
 None
 1.12A 6ce2B-5h3kA:
undetectable		 6ce2B-5h3kA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A 382
LEU A 384
PHE A 520
PHE A 524
 None
 0.97A 6h7lA-5h3kA:
undetectable		 6h7lA-5h3kA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A 382
LEU A 384
PHE A 520
PHE A 524
 None
 0.97A 6h7lB-5h3kA:
undetectable		 6h7lB-5h3kA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h3k SLR0280 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 ARG A 284
GLN A 292
PHE A 293
LEU A 568
 None
 1.23A 6nmpC-5h3kA:
undetectable
6nmpJ-5h3kA:
undetectable		 6nmpC-5h3kA:
18.17
6nmpJ-5h3kA:
5.90