SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		5 / 12 ALA A  44
ILE A  52
LEU A  26
ILE A  14
THR A  45
 None
None
CME  A  22 ( 4.7A)
None
None
 1.10A 2w3vA-5h3lA:
undetectable		 2w3vA-5h3lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		4 / 8 ASN A  28
TRP A  29
ASN A 119
THR A 118
 None
 1.31A 4d1yA-5h3lA:
2.3
4d1yB-5h3lA:
2.5		 4d1yA-5h3lA:
17.59
4d1yB-5h3lA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		5 / 10 GLN A  77
ALA A  18
THR A  45
ALA A  44
THR A  48
 None
CME  A  22 ( 3.9A)
None
None
None
 1.47A 4qw3H-5h3lA:
undetectable
4qw3I-5h3lA:
undetectable		 4qw3H-5h3lA:
19.23
4qw3I-5h3lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		5 / 11 GLN A  77
ALA A  18
THR A  45
ALA A  44
THR A  48
 None
CME  A  22 ( 3.9A)
None
None
None
 1.46A 4qw3V-5h3lA:
undetectable
4qw3W-5h3lA:
undetectable		 4qw3V-5h3lA:
19.23
4qw3W-5h3lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		4 / 6 ARG A   6
ASP A  84
HIS A  13
ILE A  83
 None
 1.36A 5a06A-5h3lA:
undetectable		 5a06A-5h3lA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		5 / 11 GLN A  77
ALA A  18
THR A  45
ALA A  44
THR A  48
 None
CME  A  22 ( 3.9A)
None
None
None
 1.50A 5cz7H-5h3lA:
0.0
5cz7I-5h3lA:
undetectable		 5cz7H-5h3lA:
19.23
5cz7I-5h3lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5h3l METHYLGLYOXAL
SYNTHASE
(synthetic
construct) 		5 / 12 GLN A  77
ALA A  18
THR A  45
ALA A  44
THR A  48
 None
CME  A  22 ( 3.9A)
None
None
None
 1.50A 5d0xH-5h3lA:
undetectable
5d0xI-5h3lA:
undetectable		 5d0xH-5h3lA:
19.23
5d0xI-5h3lA:
23.79