SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 8 ILE A 616
VAL A 491
GLY A 613
LEU A 564
 PCG  A 801 ( 4.9A)
None
None
None
 0.89A 1dzmA-5h3oA:
undetectable		 1dzmA-5h3oA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 6 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.75A 1mt1A-5h3oA:
undetectable
1mt1F-5h3oA:
undetectable		 1mt1A-5h3oA:
5.75
1mt1F-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 6 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.78A 1mt1B-5h3oA:
undetectable
1mt1C-5h3oA:
undetectable		 1mt1B-5h3oA:
8.77
1mt1C-5h3oA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 6 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.75A 1mt1G-5h3oA:
undetectable
1mt1J-5h3oA:
undetectable		 1mt1G-5h3oA:
5.75
1mt1J-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 5 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.81A 1n13B-5h3oA:
undetectable
1n13C-5h3oA:
undetectable		 1n13B-5h3oA:
8.77
1n13C-5h3oA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 6 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.77A 1n13H-5h3oA:
undetectable
1n13K-5h3oA:
undetectable		 1n13H-5h3oA:
8.77
1n13K-5h3oA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.78A 1n13G-5h3oA:
undetectable
1n13J-5h3oA:
undetectable		 1n13G-5h3oA:
5.75
1n13J-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.78A 1n13I-5h3oA:
undetectable
1n13L-5h3oA:
undetectable		 1n13I-5h3oA:
5.75
1n13L-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 LEU A 561
SER A 562
GLY A 568
ALA A 567
SER A 569
 PCG  A 801 (-3.8A)
PCG  A 801 (-3.1A)
None
None
None
 0.98A 1pxxC-5h3oA:
undetectable		 1pxxC-5h3oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 6 ALA A 324
ILE A 140
VAL A 144
PHE A 145
 None
 0.67A 2cizA-5h3oA:
undetectable		 2cizA-5h3oA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 8 ASP A 357
LEU A 336
SER A 350
LEU A 351
 None
 1.06A 2q0iA-5h3oA:
undetectable		 2q0iA-5h3oA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 LEU A 509
PHE A 588
LEU A 590
LEU A 609
VAL A 491
 None
 1.23A 2qd4B-5h3oA:
undetectable		 2qd4B-5h3oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.82A 2qqcB-5h3oA:
undetectable
2qqcC-5h3oA:
undetectable		 2qqcB-5h3oA:
8.77
2qqcC-5h3oA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.83A 2qqcA-5h3oA:
undetectable
2qqcF-5h3oA:
undetectable		 2qqcA-5h3oA:
6.38
2qqcF-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.82A 2qqcD-5h3oA:
undetectable
2qqcE-5h3oA:
undetectable		 2qqcD-5h3oA:
8.77
2qqcE-5h3oA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.78A 2qqcG-5h3oA:
undetectable
2qqcJ-5h3oA:
undetectable		 2qqcG-5h3oA:
6.38
2qqcJ-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.83A 2qqcI-5h3oA:
undetectable
2qqcL-5h3oA:
undetectable		 2qqcI-5h3oA:
6.38
2qqcL-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 7 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.79A 2qqdA-5h3oA:
undetectable
2qqdE-5h3oA:
undetectable		 2qqdA-5h3oA:
6.00
2qqdE-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		4 / 8 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.77A 2qqdB-5h3oA:
undetectable
2qqdC-5h3oA:
undetectable		 2qqdB-5h3oA:
8.77
2qqdC-5h3oA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 PHE A 514
LEU A 587
GLY A 536
PHE A 588
VAL A 582
 None
 1.41A 3dh0A-5h3oA:
undetectable		 3dh0A-5h3oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		3 / 3 ALA A 131
VAL A 127
TRP A 124
 None
 0.79A 3l8lC-5h3oA:
undetectable
3l8lD-5h3oA:
undetectable		 3l8lC-5h3oA:
1.76
3l8lD-5h3oA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		3 / 3 TYR A 174
MET A 183
LEU A 351
 None
 0.99A 3vw1D-5h3oA:
1.4		 3vw1D-5h3oA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 ILE A 316
PHE A 367
TYR A 363
LEU A 148
LEU A 359
 None
 1.33A 4j03A-5h3oA:
undetectable		 4j03A-5h3oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 ALA A 577
PHE A 558
LEU A 587
ILE A 520
THR A 576
 PCG  A 801 ( 4.5A)
None
None
None
PCG  A 801 (-3.1A)
 1.09A 4km2A-5h3oA:
undetectable		 4km2A-5h3oA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 MET A 530
LEU A 590
ILE A 493
VAL A 491
LEU A 505
 None
 1.46A 4m11A-5h3oA:
undetectable		 4m11A-5h3oA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 ASP A 594
ILE A 566
ASN A 565
GLY A 613
ARG A 575
 None
None
None
None
PCG  A 801 (-4.3A)
 1.29A 4obwC-5h3oA:
undetectable		 4obwC-5h3oA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 12 TYR A 215
ILE A 133
ARG A 280
ASN A 135
PHE A 138
 None
 1.28A 4obwC-5h3oA:
undetectable		 4obwC-5h3oA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL
(Caenorhabditis
elegans) 		5 / 11 ALA A 577
PHE A 558
LEU A 587
ILE A 520
THR A 576
 PCG  A 801 ( 4.5A)
None
None
None
PCG  A 801 (-3.1A)
 0.99A 5z6mA-5h3oA:
undetectable		 5z6mA-5h3oA:
12.45