SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		5 / 12 HIS A 126
GLU A 121
GLN A  33
ALA A  52
ARG A 154
 None
 1.19A 1ki7A-5h3xA:
undetectable		 1ki7A-5h3xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		5 / 12 ILE A  91
LEU A 100
LEU A 257
ALA A  17
LEU A  61
 None
 1.08A 3a50D-5h3xA:
undetectable		 3a50D-5h3xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		5 / 10 PHE A 244
PHE A 225
PHE A 226
GLY A 201
ASN A 172
 None
 1.40A 3r6wA-5h3xA:
undetectable
3r6wB-5h3xA:
undetectable		 3r6wA-5h3xA:
22.35
3r6wB-5h3xA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		3 / 3 LYS A 134
THR A 117
ILE A  91
 None
 0.87A 4e0fB-5h3xA:
undetectable		 4e0fB-5h3xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 5 GLY A  21
GLY A  22
ASN A  42
GLU A  89
 None
 1.25A 4fglC-5h3xA:
undetectable		 4fglC-5h3xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 6 ARG A 164
ILE A 163
ILE A  99
ASP A  97
 None
 1.18A 4w5qA-5h3xA:
undetectable		 4w5qA-5h3xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		3 / 3 MET A  11
ASP A 262
PHE A 263
 None
 1.03A 4xeyA-5h3xA:
undetectable		 4xeyA-5h3xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		3 / 3 MET A  11
ASP A 262
PHE A 263
 None
 1.01A 4xeyB-5h3xA:
undetectable		 4xeyB-5h3xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 6 ARG A 164
ILE A 163
ILE A  99
ASP A  97
 None
 1.20A 4z4cA-5h3xA:
undetectable		 4z4cA-5h3xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 6 ARG A 164
ILE A 163
ILE A  99
ASP A  97
 None
 1.19A 4z4dA-5h3xA:
undetectable		 4z4dA-5h3xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 5 PHE A 263
SER A 259
GLN A 251
ASP A 205
 None
 1.32A 5kpcA-5h3xA:
undetectable		 5kpcA-5h3xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN
(Streptococcus
suis) 		4 / 6 ARG A 164
ILE A 163
ILE A  99
ASP A  97
 None
 1.14A 6cbdA-5h3xA:
undetectable		 6cbdA-5h3xA:
16.51