SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 12 GLU A 416
ASN A 410
LEU A 374
LEU A 353
GLY A 376
 None
 1.36A 3g1uA-5h45A:
undetectable		 3g1uA-5h45A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 10 ALA A 296
LEU A 323
ALA A 354
VAL A 378
VAL A 318
 None
 1.27A 3r9cA-5h45A:
undetectable		 3r9cA-5h45A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 12 LEU A 414
VAL A 418
ALA A 356
LEU A 411
LEU A 368
 None
 1.20A 4i1rA-5h45A:
undetectable		 4i1rA-5h45A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 10 GLY A 365
VAL A 364
VAL A 363
LEU A 368
LEU A 329
 None
 1.16A 4yb6A-5h45A:
undetectable
4yb6E-5h45A:
undetectable		 4yb6A-5h45A:
22.95
4yb6E-5h45A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 10 GLY A 365
VAL A 364
VAL A 363
LEU A 368
LEU A 329
 None
 1.15A 4yb6B-5h45A:
undetectable
4yb6C-5h45A:
undetectable		 4yb6B-5h45A:
22.95
4yb6C-5h45A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 10 LEU A 368
LEU A 329
GLY A 365
VAL A 364
VAL A 363
 None
 1.15A 4yb6B-5h45A:
undetectable
4yb6F-5h45A:
undetectable		 4yb6B-5h45A:
22.95
4yb6F-5h45A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 11 PHE A 405
LEU A 340
ASP A 348
GLY A 350
ALA A 283
 None
 1.26A 6r2eF-5h45A:
undetectable		 6r2eF-5h45A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5h45 DNA REPAIR PROTEIN
RADA
(Thermus
thermophilus) 		5 / 12 PHE A 405
LEU A 340
ASP A 348
GLY A 350
ALA A 283
 None
 1.25A 6r2eH-5h45A:
undetectable		 6r2eH-5h45A:
25.30