SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  31
VAL A 112
TYR A 113
THR A  34
 None
 1.26A 1nw3A-5h46A:
undetectable		 1nw3A-5h46A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  31
ALA A 108
LEU A 109
ILE A  86
 None
 0.77A 3cldB-5h46A:
undetectable		 3cldB-5h46A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A  30
THR A  27
TYR A  28
LEU A  35
 None
 1.18A 5x1bA-5h46A:
2.5
5x1bC-5h46A:
3.9
5x1bP-5h46A:
4.2		 5x1bA-5h46A:
13.19
5x1bC-5h46A:
19.15
5x1bP-5h46A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.25A 6czmA-5h46A:
undetectable
6czmB-5h46A:
undetectable		 6czmA-5h46A:
22.08
6czmB-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.26A 6czmB-5h46A:
undetectable
6czmC-5h46A:
undetectable		 6czmB-5h46A:
22.08
6czmC-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.13A 6czmE-5h46A:
undetectable
6czmF-5h46A:
undetectable		 6czmE-5h46A:
22.08
6czmF-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  35
ASP A  30
THR A  27
TYR A  28
 None
 1.17A 6nknC-5h46A:
4.1
6nknN-5h46A:
1.5
6nknP-5h46A:
4.1		 6nknC-5h46A:
19.15
6nknN-5h46A:
13.19
6nknP-5h46A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h46 DNA PROTECTION
DURING STARVATION
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A  30
THR A  27
TYR A  28
LEU A  35
 None
 1.07A 6nmfA-5h46A:
undetectable
6nmfC-5h46A:
4.1
6nmfP-5h46A:
4.1		 6nmfA-5h46A:
13.19
6nmfC-5h46A:
19.15
6nmfP-5h46A:
19.15