SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 6 PHE A 478
ILE A 506
LYS A 518
MET A 530
 None
 1.13A 1hk2A-5h4eA:
undetectable		 1hk2A-5h4eA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 12 ILE A 325
GLY A 336
ALA A 338
GLN A 257
LEU A 267
 None
 1.29A 1i9gA-5h4eA:
undetectable		 1i9gA-5h4eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 7 GLY A 351
PRO A 340
PHE A 354
ARG A 423
 None
 0.99A 1oniG-5h4eA:
undetectable
1oniI-5h4eA:
undetectable		 1oniG-5h4eA:
17.03
1oniI-5h4eA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 11 VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 1.02A 1z11A-5h4eA:
undetectable		 1z11A-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 11 VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 1.00A 1z11B-5h4eA:
undetectable		 1z11B-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 10 VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 0.97A 1z11C-5h4eA:
undetectable		 1z11C-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		6 / 10 PHE A 480
VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 1.34A 1z11D-5h4eA:
undetectable		 1z11D-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 12 ALA A 426
TYR A 407
VAL A 411
PHE A 434
ILE A 424
 None
 1.23A 2dcfA-5h4eA:
undetectable		 2dcfA-5h4eA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 7 LEU A 263
ASN A 264
LEU A 267
TYR A 304
 None
 1.12A 2w8yA-5h4eA:
undetectable		 2w8yA-5h4eA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 12 SER A 318
GLY A 339
TYR A 316
ASN A 341
TYR A 292
 None
 1.37A 3a27A-5h4eA:
undetectable		 3a27A-5h4eA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 7 GLY A 493
PHE A 567
PHE A 507
GLY A 505
 None
 0.89A 3ko0M-5h4eA:
undetectable
3ko0P-5h4eA:
undetectable		 3ko0M-5h4eA:
14.04
3ko0P-5h4eA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 7 PHE A 507
GLY A 505
GLY A 493
PHE A 567
 None
 0.94A 3ko0M-5h4eA:
undetectable
3ko0P-5h4eA:
undetectable		 3ko0M-5h4eA:
14.04
3ko0P-5h4eA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 9 PHE A 480
VAL A 473
ILE A 491
GLY A 493
PHE A 525
 None
 1.43A 3t3rC-5h4eA:
undetectable		 3t3rC-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 6 PHE A 434
PHE A 444
ASN A 526
ALA A 552
 None
 1.14A 3t3sB-5h4eA:
undetectable		 3t3sB-5h4eA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 5 SER A 577
GLU A 358
THR A 370
TYR A 380
 None
 1.48A 3zs3A-5h4eA:
12.3		 3zs3A-5h4eA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 8 SER A 470
LEU A 460
PHE A 478
TYR A 487
 None
 1.18A 4j7uD-5h4eA:
undetectable		 4j7uD-5h4eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		5 / 11 ILE A 382
ILE A 248
ILE A 589
TYR A 380
THR A 578
 None
 1.36A 4p68A-5h4eA:
undetectable		 4p68A-5h4eA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		3 / 3 ILE A 325
ASP A 347
ARG A 314
 None
 0.83A 4pstA-5h4eA:
undetectable		 4pstA-5h4eA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		3 / 3 TYR A 316
GLY A 339
PRO A 340
 None
 0.73A 4qwpA-5h4eA:
undetectable		 4qwpA-5h4eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 5 LEU A 489
VAL A 521
VAL A 473
TYR A 469
 None
 1.08A 4r7iA-5h4eA:
undetectable		 4r7iA-5h4eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		3 / 3 ARG A 372
ASP A 396
TYR A 378
 None
 0.62A 4yo9B-5h4eA:
undetectable		 4yo9B-5h4eA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 6 TRP A 555
TYR A 565
THR A 371
SER A 577
 None
 1.44A 5b6iB-5h4eA:
undetectable		 5b6iB-5h4eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		3 / 3 VAL A 231
SER A 303
TRP A 246
 None
 0.95A 5jwaA-5h4eA:
undetectable		 5jwaA-5h4eA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5h4e BETA 1-3 GLUCANASE
(Clostridium
beijerinckii) 		4 / 5 TYR A 425
PHE A 354
MET A 353
GLY A 351
 None
 1.09A 6hd4A-5h4eA:
undetectable		 6hd4A-5h4eA:
15.67