SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		4 / 8 PHE A 178
ILE A 125
GLY A 152
GLY A 153
 None
 0.81A 2qx4A-5h4uA:
undetectable
2qx4B-5h4uA:
undetectable		 2qx4A-5h4uA:
22.75
2qx4B-5h4uA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		4 / 6 PHE A 178
ILE A 125
GLY A 152
GLY A 153
 None
 0.79A 2qx6A-5h4uA:
undetectable
2qx6B-5h4uA:
undetectable		 2qx6A-5h4uA:
22.75
2qx6B-5h4uA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		3 / 3 GLY A 129
GLY A 148
GLY A 153
 None
 0.39A 3bogC-5h4uA:
undetectable		 3bogC-5h4uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		3 / 3 GLY A 129
GLY A 148
GLY A 153
 None
 0.37A 3bogD-5h4uA:
undetectable		 3bogD-5h4uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		5 / 12 LEU A 123
THR A   2
PRO A 194
ILE A 196
VAL A   7
 None
 1.23A 5dlvB-5h4uA:
undetectable		 5dlvB-5h4uA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		5 / 12 ILE A 154
GLY A 153
ARG A  10
ARG A 174
ALA A 142
 None
 1.16A 5h5fA-5h4uA:
undetectable		 5h5fA-5h4uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		5 / 12 ILE A 154
LEU A 163
PRO A 143
GLY A 153
GLY A 146
 None
 1.21A 5nnaA-5h4uA:
undetectable		 5nnaA-5h4uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		5 / 12 ILE A 154
LEU A 163
PRO A 143
GLY A 153
GLY A 146
 None
 1.20A 5nnaC-5h4uA:
undetectable		 5nnaC-5h4uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		5 / 12 ASP A  13
GLY A 131
TYR A  11
ASN A 183
THR A   9
 None
 1.45A 5x7pB-5h4uA:
undetectable		 5x7pB-5h4uA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		4 / 4 ASP A  13
SER A  55
SER A  48
ASN A 111
 None
 1.33A 6iblA-5h4uA:
undetectable		 6iblA-5h4uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5h4u ENDO-BETA-1,4-GLUCAN
ASE
(Cryptopygus
antarcticus) 		4 / 4 ASP A  13
SER A  55
SER A  48
ASN A 111
 None
 1.31A 6iblB-5h4uA:
undetectable		 6iblB-5h4uA:
19.05