SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 10 LEU A 428
LEU A 417
GLU A 393
ALA A 413
LEU A 419
 None
 1.31A 1ie4A-5h4vA:
undetectable
1ie4C-5h4vA:
undetectable		 1ie4A-5h4vA:
13.70
1ie4C-5h4vA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 11 MET A 170
PHE A 142
ALA A  86
LEU A  89
ALA A  95
 None
 1.20A 1jb0B-5h4vA:
undetectable		 1jb0B-5h4vA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 6 LEU A 282
GLU A 281
THR A 313
TYR A 310
 None
 1.29A 1qvuA-5h4vA:
undetectable		 1qvuA-5h4vA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 6 TRP A 190
TYR A 214
ASP A 191
ARG A  81
 None
 1.49A 2a3bB-5h4vA:
undetectable		 2a3bB-5h4vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 8 SER A 405
ALA A 391
ARG A 392
LEU A 428
 None
 0.71A 2bxkA-5h4vA:
undetectable		 2bxkA-5h4vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 8 SER A 405
ALA A 391
ARG A 392
LEU A 428
 None
 0.74A 2bxmA-5h4vA:
undetectable		 2bxmA-5h4vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 8 ILE A  73
ASP A 188
ARG A   4
GLU A  70
 None
 0.89A 2cdqA-5h4vA:
2.3		 2cdqA-5h4vA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 4 LEU A 231
THR A 236
ILE A  17
HIS A  16
 None
 1.33A 2jfaB-5h4vA:
undetectable		 2jfaB-5h4vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 9 MET A 170
PHE A 142
ALA A  86
LEU A  89
ALA A  95
 None
 1.28A 2o01B-5h4vA:
undetectable		 2o01B-5h4vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 10 MET A 170
PHE A 142
ALA A  86
LEU A  89
ALA A  95
 None
 1.30A 2wscB-5h4vA:
undetectable		 2wscB-5h4vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 10 MET A 170
PHE A 142
ALA A  86
LEU A  89
ALA A  95
 None
 1.30A 2wseB-5h4vA:
undetectable		 2wseB-5h4vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 12 ALA A 244
GLY A  18
LEU A  64
VAL A 247
TYR A 250
 None
 1.00A 3o7wA-5h4vA:
undetectable		 3o7wA-5h4vA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 11 MET A 170
PHE A 142
ALA A  86
LEU A  89
ALA A  95
 None
 1.19A 3pcqB-5h4vA:
undetectable		 3pcqB-5h4vA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 5 LEU A 368
ARG A 456
ILE A 441
ARG A 429
 None
 1.04A 3ticA-5h4vA:
undetectable		 3ticA-5h4vA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 10 VAL A 445
LEU A 395
GLY A 422
ALA A 425
LEU A 428
 None
 1.08A 4ph9B-5h4vA:
undetectable		 4ph9B-5h4vA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		5 / 12 LEU A 395
ALA A 391
LEU A 388
ILE A 432
ALA A 453
 None
 1.28A 5nm5B-5h4vA:
undetectable		 5nm5B-5h4vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 8 LEU A 267
LEU A  24
ALA A  20
LEU A  64
 None
 0.84A 5y7pE-5h4vA:
undetectable		 5y7pE-5h4vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5h4v GLUTAMATE--TRNA
LIGASE
(Xanthomonas
oryzae) 		4 / 6 MET A 170
ALA A  86
LEU A  89
ALA A  95
 None
 0.84A 6fosB-5h4vA:
undetectable		 6fosB-5h4vA:
9.67