SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 PHE A 366
PRO A 377
THR A 606
TYR A 611
ALA A 383
 None
 1.10A 1fm4A-5h53A:
undetectable		 1fm4A-5h53A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 6 PHE A 491
PHE A 122
GLU A 704
GLY A 705
 None
 1.08A 1kqbA-5h53A:
undetectable
1kqbB-5h53A:
undetectable		 1kqbA-5h53A:
13.90
1kqbB-5h53A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 9 LEU A 618
ALA A 357
GLY A 387
ALA A 386
LEU A 429
 None
 1.14A 1nr6A-5h53A:
undetectable		 1nr6A-5h53A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 6 LEU A  97
MET A 495
ILE A 708
MET A  93
 None
 1.06A 2hyyC-5h53A:
undetectable		 2hyyC-5h53A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 MET A 390
LEU A 618
ALA A 357
VAL A 433
TYR A 611
 None
 1.05A 2japA-5h53A:
undetectable		 2japA-5h53A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 MET A 390
LEU A 618
ALA A 357
VAL A 433
TYR A 611
 None
 1.02A 2japB-5h53A:
undetectable		 2japB-5h53A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 MET A 390
LEU A 618
ALA A 357
VAL A 433
TYR A 611
 None
 1.05A 2japC-5h53A:
undetectable		 2japC-5h53A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 MET A 390
LEU A 618
ALA A 357
VAL A 433
TYR A 611
 None
 1.02A 2japD-5h53A:
undetectable		 2japD-5h53A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
(Oryctolagus
cuniculus) 		3 / 3 VAL C 131
GLU C 128
GLU C 132
 None
 0.75A 2nv4A-5h53C:
undetectable		 2nv4A-5h53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 5 LEU C  80
LEU C  77
MET A 801
THR C  85
 None
 1.24A 2oaxD-5h53C:
undetectable		 2oaxD-5h53C:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 10 MET A 780
ILE A 753
PRO A  82
SER A  34
GLY A 772
 None
 1.41A 2qd4B-5h53A:
undetectable		 2qd4B-5h53A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 11 ARG A 725
ARG A 781
VAL A 767
GLY A 507
GLU A 509
 None
 1.23A 3bf6H-5h53A:
undetectable		 3bf6H-5h53A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		5 / 12 ASN C  83
SER C  71
ASP C  75
LYS C 162
LEU A 795
 None
 1.43A 3cb8A-5h53C:
undetectable		 3cb8A-5h53C:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 LEU A 228
ILE A 351
LYS A 353
LEU A 299
ILE A 291
 None
 1.01A 3cd2A-5h53A:
undetectable		 3cd2A-5h53A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 LYS A 146
ILE A   9
PHE A  10
 None
 0.87A 3j7zS-5h53A:
undetectable
3j7za-5h53A:
undetectable		 3j7zS-5h53A:
9.47
3j7za-5h53A:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 ASN A 424
ASP A 601
ARG A 245
 None
 0.83A 3k13A-5h53A:
undetectable		 3k13A-5h53A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 9 ALA A 263
ASP A 264
ILE A 265
GLY A 460
ILE A 459
 None
 0.95A 3ogpB-5h53A:
undetectable		 3ogpB-5h53A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 10 ALA A 263
ASP A 264
ILE A 265
GLY A 460
ILE A 459
 None
 0.91A 3ogqA-5h53A:
undetectable		 3ogqA-5h53A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 10 ASP A 384
ALA A 386
LEU A 429
ILE A 351
ILE A 291
 None
 1.20A 3prsA-5h53A:
undetectable		 3prsA-5h53A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 11 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.84A 3t3rA-5h53A:
undetectable		 3t3rA-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 9 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.84A 3t3rB-5h53A:
undetectable		 3t3rB-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 9 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.87A 3t3rC-5h53A:
undetectable		 3t3rC-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 10 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.84A 3t3rD-5h53A:
undetectable		 3t3rD-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 ARG A 698
VAL A 102
LEU A 103
TYR A  47
LEU A 703
 None
 1.15A 4coxC-5h53A:
undetectable		 4coxC-5h53A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 7 PHE A 254
PHE A 196
ASN A 172
GLY A 460
 None
 0.97A 4ejjB-5h53A:
undetectable		 4ejjB-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 5 PHE A 254
PHE A 196
ILE A 459
GLY A 460
 None
 0.81A 4ejjC-5h53A:
undetectable		 4ejjC-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 12 LEU A 498
PHE A 496
GLY A 516
ALA A 520
GLU A 527
 None
 1.23A 4retA-5h53A:
undetectable		 4retA-5h53A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 MET A 694
GLN A 488
TYR A 584
 None
 1.06A 4udcA-5h53A:
undetectable		 4udcA-5h53A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 ILE C 180
MET A 789
ASP C 129
 None
 0.83A 5h2uA-5h53C:
undetectable		 5h2uA-5h53C:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 6 ASP A 589
ASN A 484
ASN A 473
GLN A 477
 None
 1.12A 5l6eA-5h53A:
undetectable		 5l6eA-5h53A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 TRP A 833
MET A 834
ASN A 835
 None
 1.02A 5uc1B-5h53A:
undetectable		 5uc1B-5h53A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 TRP A 833
MET A 834
ASN A 835
 None
 0.98A 5uc1A-5h53A:
undetectable		 5uc1A-5h53A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
(Oryctolagus
cuniculus) 		4 / 6 ASN C 142
ASN C 177
ARG C 151
GLU C 140
 None
 1.27A 5uigA-5h53C:
undetectable		 5uigA-5h53C:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
(Oryctolagus
cuniculus) 		4 / 6 ASN C 142
THR C 144
ASN C 177
GLU C 183
 None
 1.01A 5uigA-5h53C:
undetectable		 5uigA-5h53C:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 7 GLN A 448
GLY A 216
ILE A 223
GLN A 194
 None
 1.16A 5vlmC-5h53A:
2.6		 5vlmC-5h53A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		3 / 3 LYS A  19
PRO A  20
LYS A  22
 None
 1.32A 5y9yA-5h53A:
undetectable		 5y9yA-5h53A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		5 / 9 ILE A 115
ARG A  18
ALA A  14
LEU A  17
ALA A 151
 None
 1.49A 5zgbB-5h53A:
undetectable		 5zgbB-5h53A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 5 THR A 202
ARG A 144
THR A 168
ASP A 171
 None
 1.40A 6ectA-5h53A:
undetectable		 6ectA-5h53A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL
(Oryctolagus
cuniculus) 		4 / 6 ASN A 625
TYR A 626
VAL A 442
THR A 443
 None
 1.34A 6f32B-5h53A:
undetectable		 6f32B-5h53A:
19.15