SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		5 / 10 VAL B 169
VAL B 133
VAL B 155
TYR B  98
LEU B 128
 None
 1.17A 1fe2A-5h5bB:
undetectable		 1fe2A-5h5bB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 6 TYR B  98
GLY B  38
SER B  67
ARG B  47
 None
 1.38A 2a3cA-5h5bB:
undetectable		 2a3cA-5h5bB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 6 TYR B  98
GLY B  38
SER B  67
ARG B  47
 None
 1.33A 2a3cB-5h5bB:
undetectable		 2a3cB-5h5bB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		5 / 12 GLY B  43
GLY B  39
GLU B  44
ARG B  47
GLU B  36
 None
 1.19A 2vdvE-5h5bB:
undetectable		 2vdvE-5h5bB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		5 / 11 GLY B  43
GLY B  39
GLU B  44
ARG B  47
GLU B  36
 None
 1.19A 2vdvF-5h5bB:
undetectable		 2vdvF-5h5bB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		3 / 3 LEU B  24
TYR B  23
GLN B  26
 None
 0.75A 2wekA-5h5bB:
undetectable		 2wekA-5h5bB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		3 / 3 VAL B 170
VAL B 192
SER B 190
 None
 0.74A 3n8xB-5h5bB:
undetectable		 3n8xB-5h5bB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 4 PHE B  91
TYR B  34
ILE B 172
LEU B 128
 None
 1.27A 3sudA-5h5bB:
undetectable		 3sudA-5h5bB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 5 PHE B  91
TYR B  34
ILE B 172
LEU B 128
 None
 1.14A 3sueC-5h5bB:
undetectable		 3sueC-5h5bB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 6 GLU B  36
GLY B  38
LEU B  88
TYR B  34
 None
 1.17A 3w9tE-5h5bB:
undetectable		 3w9tE-5h5bB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 6 GLU B  36
GLY B  38
LEU B  88
TYR B  34
 None
 1.16A 3w9tF-5h5bB:
undetectable		 3w9tF-5h5bB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 6 ARG B 145
ARG B  47
ARG B  90
ASP B   9
 FLC  B 201 (-3.0A)
None
None
FLC  B 201 (-4.6A)
 1.12A 4xqeA-5h5bB:
2.2		 4xqeA-5h5bB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 8 ARG B 145
ARG B  47
ARG B  90
ASP B   9
 FLC  B 201 (-3.0A)
None
None
FLC  B 201 (-4.6A)
 1.09A 4xqgA-5h5bB:
undetectable		 4xqgA-5h5bB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 8 ARG B 145
ARG B  47
ARG B  90
ASP B   9
 FLC  B 201 (-3.0A)
None
None
FLC  B 201 (-4.6A)
 1.09A 4xqgB-5h5bB:
undetectable		 4xqgB-5h5bB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		4 / 4 GLN B  99
THR B  95
LEU B  46
LEU B  50
 None
 1.23A 5m5kB-5h5bB:
undetectable		 5m5kB-5h5bB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5h5b THYMIDYLATE KINASE
(Aquifex
aeolicus) 		5 / 11 LEU B  24
ILE B 185
PHE B 182
ILE B   3
ILE B  87
 None
 1.07A 6gp2A-5h5bB:
undetectable		 6gp2A-5h5bB:
15.82