SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 10 LEU A 204
VAL A 208
VAL A 251
GLY A 207
TYR A 233
 None
 1.37A 1fkoA-5h5jA:
undetectable		 1fkoA-5h5jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 6 ARG A 182
GLY A 110
ASP A 103
TYR A  67
 None
 0.79A 1kf6M-5h5jA:
undetectable
1kf6N-5h5jA:
undetectable		 1kf6M-5h5jA:
19.57
1kf6N-5h5jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 11 GLY A  63
ARG A 187
GLU A  19
HIS A  17
LEU A  18
 None
 1.43A 1mjqA-5h5jA:
undetectable
1mjqB-5h5jA:
undetectable		 1mjqA-5h5jA:
16.99
1mjqB-5h5jA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 10 ARG A 187
GLU A  19
HIS A  17
LEU A  18
GLY A  63
 None
 1.41A 1mjqC-5h5jA:
undetectable
1mjqD-5h5jA:
undetectable		 1mjqC-5h5jA:
16.99
1mjqD-5h5jA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 10 GLY A  63
ARG A 187
GLU A  19
HIS A  17
LEU A  18
 None
 1.42A 1mjqG-5h5jA:
undetectable
1mjqH-5h5jA:
undetectable		 1mjqG-5h5jA:
16.99
1mjqH-5h5jA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 8 TYR A 216
VAL A  58
GLU A 219
ASP A 103
 None
 1.15A 1s3zA-5h5jA:
undetectable
1s3zB-5h5jA:
undetectable		 1s3zA-5h5jA:
17.61
1s3zB-5h5jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		3 / 3 THR A  28
THR A 151
PRO A 153
 None
 0.82A 209dC-5h5jA:
undetectable		 209dC-5h5jA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 MET A 158
PHE A 181
PHE A 205
ILE A 255
ILE A 262
 None
 1.32A 2bjfA-5h5jA:
undetectable		 2bjfA-5h5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 LEU A 204
GLY A 177
CYH A 113
ALA A 179
ALA A  97
 None
None
None
FAD  A 401 ( 4.4A)
None
 1.07A 2br4A-5h5jA:
3.7		 2br4A-5h5jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 LEU A 204
GLY A 177
CYH A 113
ALA A 179
ALA A  97
 None
None
None
FAD  A 401 ( 4.4A)
None
 1.16A 2br4D-5h5jA:
3.9		 2br4D-5h5jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 6 ARG A 182
PRO A 161
GLY A  70
MET A 158
 None
 1.49A 3aqiB-5h5jA:
undetectable		 3aqiB-5h5jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		6 / 12 GLY A 152
ASN A  27
ILE A  96
GLN A  71
GLY A 110
HIS A  61
 None
 1.44A 3eeyB-5h5jA:
undetectable		 3eeyB-5h5jA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 GLY A 152
ASN A  27
ILE A  96
GLY A 110
HIS A  61
 None
 1.20A 3eeyD-5h5jA:
4.7		 3eeyD-5h5jA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 GLY A 152
ASN A  27
ILE A  96
GLY A 110
HIS A  61
 None
 1.20A 3eeyJ-5h5jA:
2.7		 3eeyJ-5h5jA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 7 VAL A 178
LEU A 204
TYR A 233
LEU A 237
 None
 1.06A 3qeoB-5h5jA:
undetectable		 3qeoB-5h5jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 6 ARG A 187
GLY A 183
GLU A 191
GLN A  71
 None
 1.30A 4g0vB-5h5jA:
undetectable		 4g0vB-5h5jA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 6 ASP A  60
GLY A 110
PRO A 153
THR A  28
 None
 1.10A 4l1aB-5h5jA:
undetectable		 4l1aB-5h5jA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 10 GLU A 162
PHE A 189
LEU A 185
ALA A 202
ALA A 167
 None
 1.28A 4wnuD-5h5jA:
undetectable		 4wnuD-5h5jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 ASP A 164
ALA A 167
PHE A 198
THR A  99
GLU A 162
 None
 1.31A 5hfjA-5h5jA:
2.5		 5hfjA-5h5jA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 4 GLN A 305
LEU A 306
ASN A 309
GLN A 311
 None
 0.28A 5vw3A-5h5jA:
49.4		 5vw3A-5h5jA:
97.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		8 / 9 SER A  95
THR A 176
GLY A 177
ALA A 179
CYH A 275
GLY A 276
LEU A 277
GLU A 315
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.3A)
None
FAD  A 401 ( 4.4A)
None
None
None
FAD  A 401 (-3.5A)
 0.57A 5vw4A-5h5jA:
49.6		 5vw4A-5h5jA:
97.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 8 SER A  95
CYH A 275
GLY A 276
LEU A 277
GLU A 315
 FAD  A 401 (-3.5A)
None
None
None
FAD  A 401 (-3.5A)
 0.72A 5vw5A-5h5jA:
49.6		 5vw5A-5h5jA:
97.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		6 / 8 SER A  95
THR A 176
GLY A 177
CYH A 275
GLY A 276
LEU A 277
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.3A)
None
None
None
None
 0.15A 5vw5A-5h5jA:
49.6		 5vw5A-5h5jA:
97.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 5 ALA A  97
SER A 111
GLY A 110
TYR A  67
 None
 1.12A 5yodB-5h5jA:
undetectable		 5yodB-5h5jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 5 ALA A  97
SER A 111
GLY A 110
TYR A  67
 None
 1.18A 5yodD-5h5jA:
undetectable		 5yodD-5h5jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 12 PRO A  24
ILE A  96
LEU A 159
LEU A 112
LEU A 150
 None
 1.12A 6b52A-5h5jA:
undetectable		 6b52A-5h5jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		5 / 10 LEU A 150
ALA A  37
GLU A  69
SER A  98
VAL A  40
 None
 1.42A 6b89B-5h5jA:
undetectable		 6b89B-5h5jA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		4 / 4 ARG A 100
GLU A  19
GLU A 162
ARG A 187
 None
 1.31A 6fk2A-5h5jA:
undetectable		 6fk2A-5h5jA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		3 / 3 ARG A 239
LYS A 248
TYR A 250
 None
 1.27A 6gnaA-5h5jA:
3.1		 6gnaA-5h5jA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5h5j FERREDOXIN--NADP
REDUCTASE
(Zea
mays) 		3 / 3 ARG A 239
LYS A 248
TYR A 250
 None
 1.27A 6gnbA-5h5jA:
3.1		 6gnbA-5h5jA:
22.69