SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1426_0
(FPRA)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 4 ASP A 382
HIS A 512
ARG A 320
GLU A 515
 None
 1.44A 1lquA-5h5mA:
undetectable		 1lquA-5h5mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 8 LYS A 482
GLU A 479
ILE A 396
LYS A 403
 None
 0.97A 2j9dJ-5h5mA:
undetectable
2j9dK-5h5mA:
undetectable
2j9dL-5h5mA:
undetectable		 2j9dJ-5h5mA:
15.08
2j9dK-5h5mA:
15.08
2j9dL-5h5mA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 8 ASP A 497
SER A 385
SER A 509
ASP A 557
 None
 1.15A 2obvA-5h5mA:
undetectable		 2obvA-5h5mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2q6hA-5h5mA:
undetectable		 2q6hA-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2q72A-5h5mA:
undetectable		 2q72A-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2qb4A-5h5mA:
2.7		 2qb4A-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.17A 2qeiA-5h5mA:
undetectable		 2qeiA-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.19A 2qjuA-5h5mA:
undetectable		 2qjuA-5h5mA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 5 ILE A 283
HIS A 366
TYR A 345
GLY A 361
 None
 1.21A 3b9mA-5h5mA:
4.3		 3b9mA-5h5mA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		3 / 3 PHE A 620
CYH A 624
PHE A 590
 None
 1.15A 3cr5X-5h5mA:
undetectable		 3cr5X-5h5mA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 ALA A 507
SER A 509
VAL A 381
ARG A 378
 None
 1.16A 4ijiH-5h5mA:
2.4		 4ijiH-5h5mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 10 LEU A 496
LEU A 492
LEU A 451
ILE A 384
HIS A 420
 None
 1.32A 4mk4A-5h5mA:
undetectable		 4mk4A-5h5mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 8 ASP A 497
SER A 385
SER A 509
ASP A 557
 None
 1.19A 4ndnA-5h5mA:
undetectable		 4ndnA-5h5mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 5 ASP A 390
LEU A 389
ARG A 320
THR A 393
 None
 1.38A 4p3qA-5h5mA:
undetectable		 4p3qA-5h5mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 VAL A 307
SER A 308
ALA A 311
ARG A 335
 None
 0.66A 5fpdA-5h5mA:
undetectable		 5fpdA-5h5mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 6 ARG A 554
ARG A 551
ALA A 552
PHE A 505
 None
 1.22A 5odqA-5h5mA:
undetectable		 5odqA-5h5mA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 ILE A 384
ASP A 497
PHE A 505
SER A 509
LEU A 492
 None
 1.36A 5tiyA-5h5mA:
undetectable		 5tiyA-5h5mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 8 GLU A 515
PHE A 388
SER A 431
LEU A 492
 None
 1.08A 5y2tB-5h5mA:
undetectable		 5y2tB-5h5mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		3 / 3 ARG A 551
ILE A 513
SER A 509
 None
 0.50A 5zw2A-5h5mA:
3.1		 5zw2A-5h5mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		3 / 3 ASP A 371
ASP A 503
ASN A 641
 None
 0.84A 6gngB-5h5mA:
undetectable		 6gngB-5h5mA:
19.58