SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		4 / 8 SER A 144
SER A 148
ASN A 147
THR A 123
 None
 1.08A 1ig3A-5h5wA:
undetectable
1ig3B-5h5wA:
undetectable		 1ig3A-5h5wA:
23.84
1ig3B-5h5wA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		5 / 12 ILE A 130
THR A 112
THR A 110
LEU A 150
ILE A 153
 None
 1.14A 1kqwA-5h5wA:
undetectable		 1kqwA-5h5wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		4 / 6 ALA A 156
LEU A 201
LEU A 178
LEU A 193
 None
 0.92A 1mt1D-5h5wA:
undetectable
1mt1E-5h5wA:
undetectable		 1mt1D-5h5wA:
15.92
1mt1E-5h5wA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		5 / 12 ILE A 168
ALA A 166
ALA A 156
LEU A 201
ILE A 143
 None
 0.97A 2h79A-5h5wA:
undetectable		 2h79A-5h5wA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		4 / 8 THR A 192
GLN A 131
ASP A 208
SER A 210
 None
 1.27A 2xz5C-5h5wA:
undetectable
2xz5D-5h5wA:
undetectable		 2xz5C-5h5wA:
23.55
2xz5D-5h5wA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		5 / 12 ILE A 168
ALA A 166
ALA A 156
LEU A 201
ILE A 143
 None
 0.94A 3gwsX-5h5wA:
undetectable		 3gwsX-5h5wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		4 / 7 LEU A 252
ALA A  81
THR A  79
SER A  78
 None
 1.13A 4iklA-5h5wA:
undetectable
4iklB-5h5wA:
undetectable		 4iklA-5h5wA:
19.90
4iklB-5h5wA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		5 / 12 LEU A 201
GLY A 206
LEU A 108
ILE A 130
VAL A 164
 None
 1.14A 4ok1A-5h5wA:
undetectable		 4ok1A-5h5wA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		5 / 11 VAL A 164
VAL A 180
ILE A 143
ILE A 153
LEU A 193
 None
 0.89A 5e4dB-5h5wA:
undetectable		 5e4dB-5h5wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2
(Escherichia
coli) 		3 / 3 ASN A 189
SER A 237
SER A 238
 None
 0.44A 5gsnA-5h5wA:
undetectable		 5gsnA-5h5wA:
16.19