SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		6 / 11 GLY A  26
ALA A  28
ASP A  50
ASP A  76
VAL A  77
ALA A 104
 NAI  A 301 (-3.3A)
NAI  A 301 ( 3.8A)
NAI  A 301 (-2.9A)
NAI  A 301 (-4.0A)
NAI  A 301 (-3.7A)
NAI  A 301 (-3.6A)
 0.46A 1uayA-5h5xA:
30.8		 1uayA-5h5xA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		6 / 10 GLY A  26
ALA A  28
ASP A  50
ASP A  76
VAL A  77
ALA A 104
 NAI  A 301 (-3.3A)
NAI  A 301 ( 3.8A)
NAI  A 301 (-2.9A)
NAI  A 301 (-4.0A)
NAI  A 301 (-3.7A)
NAI  A 301 (-3.6A)
 0.44A 1uayB-5h5xA:
31.1		 1uayB-5h5xA:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  59
ALA A  56
ARG A  64
ALA A  61
VAL A 101
 None
 1.06A 1xiuB-5h5xA:
undetectable		 1xiuB-5h5xA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		4 / 5 LEU A  97
PRO A 141
ALA A 142
ILE A 143
 None
 0.89A 2aofB-5h5xA:
undetectable		 2aofB-5h5xA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A  26
ASP A  50
ASP A  76
ASN A 103
ALA A 104
 NAI  A 301 (-3.3A)
NAI  A 301 (-2.9A)
NAI  A 301 (-4.0A)
NAI  A 301 (-3.3A)
NAI  A 301 (-3.6A)
 0.96A 2bm9E-5h5xA:
5.5		 2bm9E-5h5xA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		4 / 5 TYR A 138
SER A 135
TYR A 134
ARG A 137
 None
 1.32A 2kqeA-5h5xA:
undetectable		 2kqeA-5h5xA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 131
ASP A  76
GLY A  26
VAL A  87
VAL A  83
 None
NAI  A 301 (-4.0A)
NAI  A 301 (-3.3A)
None
None
 0.96A 2nnkB-5h5xA:
undetectable		 2nnkB-5h5xA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 10 ASP A  50
ASN A  52
ALA A  28
ASP A  76
VAL A  77
 NAI  A 301 (-2.9A)
None
NAI  A 301 ( 3.8A)
NAI  A 301 (-4.0A)
NAI  A 301 (-3.7A)
 1.04A 3ay0A-5h5xA:
6.7		 3ay0A-5h5xA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 146
GLY A  19
ILE A 143
SER A  96
LEU A  97
 None
 1.27A 3gyqA-5h5xA:
3.0
3gyqB-5h5xA:
3.0		 3gyqA-5h5xA:
23.05
3gyqB-5h5xA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		4 / 7 LEU A  23
LEU A  75
ASN A 102
THR A  78
 None
NAI  A 301 (-4.7A)
None
NAI  A 301 ( 4.4A)
 1.00A 3lm8A-5h5xA:
3.0
3lm8C-5h5xA:
2.8		 3lm8A-5h5xA:
23.61
3lm8C-5h5xA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A  26
ILE A  31
ASP A  50
ASN A  52
ASP A  76
 NAI  A 301 (-3.3A)
NAI  A 301 (-4.2A)
NAI  A 301 (-2.9A)
None
NAI  A 301 (-4.0A)
 1.14A 3q87B-5h5xA:
6.6		 3q87B-5h5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 THR A 205
ILE A  31
ASP A  50
ASN A  52
ASP A  76
 NAI  A 301 (-3.4A)
NAI  A 301 (-4.2A)
NAI  A 301 (-2.9A)
None
NAI  A 301 (-4.0A)
 1.13A 3q87B-5h5xA:
6.6		 3q87B-5h5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 11 GLY A 105
ALA A 104
ASP A  50
ILE A 238
VAL A  77
 NAI  A 301 (-3.3A)
NAI  A 301 (-3.6A)
NAI  A 301 (-2.9A)
None
NAI  A 301 (-3.7A)
 1.13A 4l1aA-5h5xA:
undetectable		 4l1aA-5h5xA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  63
ALA A  36
ALA A  56
LYS A  58
ALA A  60
 None
 1.20A 4x1iB-5h5xA:
6.7		 4x1iB-5h5xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 9 LEU A 242
ASP A  98
ALA A  22
VAL A  47
GLU A 139
 None
 0.97A 4zbrA-5h5xA:
undetectable		 4zbrA-5h5xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 234
GLU A 233
LEU A 159
ARG A 227
LEU A 228
 None
None
IPA  A 302 ( 4.4A)
None
None
 1.42A 5nd2B-5h5xA:
6.4		 5nd2B-5h5xA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5h5x PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 257
GLY A 201
PHE A 202
ALA A 262
VAL A 263
 None
IPA  A 302 (-4.8A)
IPA  A 302 (-3.3A)
None
None
 1.16A 5x66F-5h5xA:
undetectable		 5x66F-5h5xA:
23.08