SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 LEU A2508
VAL A2504
ILE A2333
LEU A2201
VAL A2417
 None
 1.20A 1cqpA-5h64A:
undetectable
1cqpB-5h64A:
undetectable		 1cqpA-5h64A:
5.88
1cqpB-5h64A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 PHE A2108
LEU A2051
SER A2035
 None
 0.89A 1e7aA-5h64A:
undetectable		 1e7aA-5h64A:
12.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2031
SER A2035
GLY A2040
PHE A2108
 None
 0.75A 1fapB-5h64A:
14.2		 1fapB-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2031
SER A2035
PHE A2039
GLY A2040
 None
 0.48A 1fapB-5h64A:
14.2		 1fapB-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2031
SER A2035
TRP A2101
PHE A2108
 None
 0.90A 1fapB-5h64A:
14.2		 1fapB-5h64A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 GLU A2388
ARG A2322
THR A2399
ALA A1428
 None
 1.07A 1fo4B-5h64A:
undetectable		 1fo4B-5h64A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 LEU A2346
MET A2382
LEU A2383
ILE A2250
LEU A2302
 None
 1.30A 1pcgA-5h64A:
undetectable		 1pcgA-5h64A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W9E_A_BEZA1274_0
(SYNTENIN 1)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 HIS A 759
SER A 762
ARG A 766
ASN A 763
 None
 1.36A 1w9eA-5h64A:
0.0		 1w9eA-5h64A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 GLY A2391
GLU A2388
LEU A2379
HIS A2401
ALA A1428
 None
 1.20A 2a58A-5h64A:
undetectable
2a58E-5h64A:
undetectable		 2a58A-5h64A:
5.11
2a58E-5h64A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 HIS A2401
ALA A1428
GLY A2391
GLU A2388
LEU A2379
 None
 1.22A 2a58A-5h64A:
undetectable
2a58B-5h64A:
undetectable		 2a58A-5h64A:
5.11
2a58B-5h64A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 HIS A2401
ALA A1428
GLY A2391
GLU A2388
LEU A2379
 None
 1.22A 2a58B-5h64A:
undetectable
2a58C-5h64A:
undetectable		 2a58B-5h64A:
5.11
2a58C-5h64A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 HIS A2401
ALA A1428
GLY A2391
GLU A2388
LEU A2379
 None
 1.21A 2a58C-5h64A:
undetectable
2a58D-5h64A:
undetectable		 2a58C-5h64A:
5.11
2a58D-5h64A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 HIS A2401
ALA A1428
GLY A2391
GLU A2388
LEU A2379
 None
 1.22A 2a58D-5h64A:
undetectable
2a58E-5h64A:
undetectable		 2a58D-5h64A:
5.11
2a58E-5h64A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 SER A 922
ASP A 911
CYH A1593
 None
 0.96A 2br4E-5h64A:
undetectable		 2br4E-5h64A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LYS A2187
LEU A2186
PHE A2184
LEU A2230
 None
 1.04A 2dysP-5h64A:
2.2
2dysW-5h64A:
undetectable		 2dysP-5h64A:
6.94
2dysW-5h64A:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2204
GLN A2200
PHE A2202
LEU A2208
 None
 1.04A 2einP-5h64A:
3.6
2einW-5h64A:
undetectable		 2einP-5h64A:
6.94
2einW-5h64A:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 12 GLY A1104
GLY A1064
ASP A1140
ASP A1147
LEU A1111
VAL A1060
 None
 1.40A 2hmyB-5h64A:
undetectable		 2hmyB-5h64A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 GLN A1774
TYR A1775
TYR A1776
ILE A1764
 None
 1.34A 2ph9A-5h64A:
undetectable
2ph9B-5h64A:
undetectable		 2ph9A-5h64A:
6.22
2ph9B-5h64A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 PRO A1116
VAL A1119
GLN A1183
ARG A1154
ILE A1155
 None
 1.11A 2v95A-5h64A:
undetectable		 2v95A-5h64A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A2354
MET A2345
MET A2387
 None
 1.03A 2vavF-5h64A:
undetectable		 2vavF-5h64A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 LEU A1111
ARG A1141
ASP A1085
PHE A1082
VAL A1081
 None
 1.17A 2vavJ-5h64A:
0.0		 2vavJ-5h64A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LEU A1642
LEU A1596
MET A1529
MET A1595
 None
 1.18A 2w8yA-5h64A:
undetectable		 2w8yA-5h64A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A 767
ARG A 766
ILE A 768
 None
 0.67A 2xn5B-5h64A:
undetectable		 2xn5B-5h64A:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 LEU A1493
ALA A1518
MET A1515
LEU A1478
GLN A1634
 None
 1.14A 3bszE-5h64A:
undetectable		 3bszE-5h64A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 PRO A2522
VAL A2525
THR A2390
GLY A2391
 None
 1.05A 3elzB-5h64A:
undetectable		 3elzB-5h64A:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 THR A1977
LEU A2005
ILE A2151
ILE A2150
LEU A2236
 None
 1.26A 3gwxA-5h64A:
undetectable		 3gwxA-5h64A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 THR A2380
THR A2384
LEU A2299
ILE A2250
LEU A2392
 None
 1.21A 3gwxB-5h64A:
undetectable		 3gwxB-5h64A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 SER A1895
HIS A1791
GLN A1901
LEU A2208
THR A2207
 None
 1.32A 3lxeA-5h64A:
undetectable		 3lxeA-5h64A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 GLU A2388
ARG A2322
THR A2399
ALA A1428
 None
 1.08A 3ns1C-5h64A:
undetectable		 3ns1C-5h64A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 HIS A2355
GLU A2373
ARG A2339
PRO A2376
 None
 1.39A 3ql6A-5h64A:
undetectable		 3ql6A-5h64A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ALA A1990
LEU A1995
ASN A1997
MET A1998
ILE A1943
 None
 1.12A 3ut5B-5h64A:
undetectable		 3ut5B-5h64A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 ARG A1514
ARG A1547
ASP A1539
 None
 0.84A 3wipG-5h64A:
undetectable
3wipH-5h64A:
undetectable		 3wipG-5h64A:
6.79
3wipH-5h64A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 TRP A1633
ARG A1628
LEU A1623
GLU A1598
 None
 1.49A 3zmdA-5h64A:
undetectable
3zmdB-5h64A:
undetectable		 3zmdA-5h64A:
5.43
3zmdB-5h64A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 GLN A 908
ASP A1565
GLN A1561
 None
 0.87A 4aztA-5h64A:
3.8		 4aztA-5h64A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 HIS A1398
GLU A1385
ASN A1378
 None
 0.86A 4bupB-5h64A:
undetectable		 4bupB-5h64A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 ARG A2042
THR A2098
TRP A2101
 None
 1.20A 4d7hA-5h64A:
undetectable		 4d7hA-5h64A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 LEU A2031
GLU A2032
SER A2035
PHE A2039
TRP A2101
 None
 0.93A 4driB-5h64A:
14.4		 4driB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 10 LEU A2031
GLU A2032
SER A2035
THR A2098
TRP A2101
PHE A2108
 None
 0.90A 4driB-5h64A:
14.4		 4driB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2031
SER A2035
THR A2098
PHE A2108
 None
 0.89A 4drjB-5h64A:
15.0		 4drjB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2031
SER A2035
TRP A2101
PHE A2108
 None
 0.83A 4drjB-5h64A:
15.0		 4drjB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1636
GLY A1588
ALA A1589
SER A1592
LEU A1596
 None
 0.91A 4e1gB-5h64A:
undetectable		 4e1gB-5h64A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 MET A1638
SER A1641
LEU A1523
GLY A1524
MET A1467
 None
 1.39A 4fe1A-5h64A:
4.2
4fe1J-5h64A:
undetectable		 4fe1A-5h64A:
14.33
4fe1J-5h64A:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 ASN A 870
LEU A 872
ASP A 830
GLU A 866
 None
 0.93A 4g24A-5h64A:
undetectable		 4g24A-5h64A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ARG A1628
TYR A1587
ARG A1585
GLU A1598
 None
 1.41A 4kr4C-5h64A:
undetectable		 4kr4C-5h64A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 PHE A2070
GLY A2030
ALA A2034
LEU A2031
GLN A2082
 None
 1.00A 4l8fD-5h64A:
undetectable		 4l8fD-5h64A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 ARG A2042
THR A2098
TRP A2101
 None
 1.14A 4ug5A-5h64A:
undetectable		 4ug5A-5h64A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 ARG A2042
THR A2098
TRP A2101
 None
 1.14A 4uglA-5h64A:
undetectable		 4uglA-5h64A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ARG A2408
ARG A2511
VAL A2504
ASP A2512
 None
 1.13A 4xqgA-5h64A:
undetectable		 4xqgA-5h64A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ARG A2408
ARG A2511
VAL A2504
ASP A2512
 None
 1.13A 4xqgB-5h64A:
undetectable		 4xqgB-5h64A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A1142
ASP A1147
LEU A1115
ILE A1156
 None
 1.20A 4y4dA-5h64A:
undetectable		 4y4dA-5h64A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 LEU A 869
VAL A 867
LEU A 891
GLY A 852
SER A 913
 None
 1.14A 4zbqA-5h64A:
undetectable		 4zbqA-5h64A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 VAL A2044
ILE A2017
PRO A2053
THR A1983
 None
 0.94A 4ze1A-5h64A:
undetectable		 4ze1A-5h64A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 MET A1512
LEU A1478
GLU A1451
LEU A1493
 None
 1.10A 5dxeA-5h64A:
undetectable		 5dxeA-5h64A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 TRP A2027
GLY A2030
VAL A2050
HIS A2055
 None
 1.15A 5ewuB-5h64A:
1.7		 5ewuB-5h64A:
9.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 8 GLU A2032
SER A2035
GLY A2040
THR A2098
TRP A2101
 None
 1.48A 5flcB-5h64A:
undetectable		 5flcB-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 8 GLU A2032
SER A2035
GLY A2040
TRP A2101
PHE A2108
 None
 1.12A 5flcB-5h64A:
undetectable		 5flcB-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 8 GLU A2032
SER A2035
PHE A2039
GLY A2040
TRP A2101
 None
 1.31A 5flcB-5h64A:
undetectable		 5flcB-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 8 GLU A2032
SER A2035
GLY A2040
THR A2098
TRP A2101
PHE A2108
 None
 1.38A 5flcF-5h64A:
11.8		 5flcF-5h64A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 8 GLU A2032
SER A2035
PHE A2039
GLY A2040
TRP A2101
 None
 1.31A 5flcF-5h64A:
11.8		 5flcF-5h64A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 ARG A2042
THR A2098
TRP A2101
 None
 1.16A 5g6cA-5h64A:
undetectable		 5g6cA-5h64A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 9 LEU A2031
SER A2035
THR A2098
TRP A2101
PHE A2108
 None
 0.94A 5gpgB-5h64A:
14.2		 5gpgB-5h64A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 SER A 920
SER A 922
SER A 923
SER A1582
 None
 1.40A 5hswA-5h64A:
undetectable		 5hswA-5h64A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 LEU A 955
ARG A 960
ILE A 958
PHE A 959
 None
 1.15A 5kirB-5h64A:
undetectable		 5kirB-5h64A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 THR A1780
SER A1893
ALA A1794
ASP A1902
 None
 1.13A 5l5fY-5h64A:
undetectable
5l5fZ-5h64A:
undetectable		 5l5fY-5h64A:
6.18
5l5fZ-5h64A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 GLU A2196
LEU A1956
THR A1962
PRO A1975
LEU A1976
 None
 1.18A 5mm4B-5h64A:
undetectable		 5mm4B-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 9 LEU A 757
ILE A 746
GLY A 747
GLY A 793
LEU A 760
 None
 0.94A 5o96A-5h64A:
undetectable
5o96B-5h64A:
undetectable		 5o96A-5h64A:
6.77
5o96B-5h64A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1118
LEU A1136
ILE A1155
PHE A1122
LEU A1111
 None
 1.33A 5tiwB-5h64A:
undetectable		 5tiwB-5h64A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 ALA A1459
LEU A1460
VAL A1461
LEU A1487
GLU A1455
 None
 1.11A 5v02B-5h64A:
3.7
5v02R-5h64A:
undetectable		 5v02B-5h64A:
3.63
5v02R-5h64A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 GLU A2264
THR A2294
THR A2384
LEU A2538
 None
 1.37A 5v96A-5h64A:
undetectable		 5v96A-5h64A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 GLU A2264
THR A2294
THR A2384
LEU A2538
 None
 1.39A 5v96B-5h64A:
undetectable		 5v96B-5h64A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 GLU A2264
THR A2294
THR A2384
LEU A2538
 None
 1.38A 5v96D-5h64A:
undetectable		 5v96D-5h64A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LYS A2187
LEU A2186
PHE A2184
LEU A2230
 None
 0.98A 5w97C-5h64A:
5.8
5w97J-5h64A:
undetectable		 5w97C-5h64A:
6.94
5w97J-5h64A:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 LEU A2209
ILE A2222
LEU A2201
PHE A2358
VAL A2403
 None
 1.12A 6ajiA-5h64A:
undetectable		 6ajiA-5h64A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 MET A1512
LEU A1478
GLU A1451
LEU A1493
 None
 1.08A 6cbzA-5h64A:
undetectable		 6cbzA-5h64A:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 LEU A2236
THR A2173
PRO A2169
ARG A2168
 None
 1.35A 6ew0B-5h64A:
undetectable		 6ew0B-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 LEU A2236
THR A2173
PRO A2169
ARG A2168
 None
 1.35A 6ew0D-5h64A:
undetectable		 6ew0D-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 LEU A2236
THR A2173
PRO A2169
ARG A2168
 None
 1.35A 6ew0H-5h64A:
undetectable		 6ew0H-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 LEU A2236
THR A2173
PRO A2169
ARG A2168
 None
 1.35A 6ew0I-5h64A:
undetectable		 6ew0I-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 ALA A1462
TYR A1463
GLN A1446
ILE A1445
 None
 1.13A 6f6sA-5h64A:
undetectable
6f6sB-5h64A:
undetectable		 6f6sA-5h64A:
2.80
6f6sB-5h64A:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 HIS A1206
ASN A1205
LEU A1199
 None
 0.80A 6f7lB-5h64A:
undetectable		 6f7lB-5h64A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 ASP A1109
ILE A1075
PRO A1076
LEU A1074
 None
 1.22A 6mkeB-5h64A:
undetectable		 6mkeB-5h64A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 ASP A1109
ILE A1075
PRO A1076
LEU A1074
 None
 1.25A 6mkeA-5h64A:
undetectable		 6mkeA-5h64A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 THR A1870
GLU A1766
ASN A1808
 None
 0.91A 6nj9K-5h64A:
undetectable		 6nj9K-5h64A:
9.82