SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		4 / 4 THR A 184
LEU A 188
VAL A 191
LEU A 195
 None
 0.94A 1mz9D-5h67A:
1.9		 1mz9D-5h67A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 11 LEU B1160
ILE B1147
THR B1148
ILE B1145
VAL B1146
 None
 1.17A 1pkvA-5h67B:
undetectable
1pkvB-5h67B:
undetectable		 1pkvA-5h67B:
20.62
1pkvB-5h67B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 11 ILE B1145
VAL B1146
LEU B1160
ILE B1147
THR B1148
 None
 1.17A 1pkvA-5h67B:
undetectable
1pkvB-5h67B:
undetectable		 1pkvA-5h67B:
20.62
1pkvB-5h67B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 ILE B1105
ILE A 141
LEU B1116
CYH B1114
VAL B1111
 None
 1.17A 2qo5A-5h67B:
undetectable		 2qo5A-5h67B:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 10 ILE A 140
ALA A 137
PHE A 128
THR B1142
LEU A   3
 None
 1.07A 2w3aB-5h67A:
undetectable		 2w3aB-5h67A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		6 / 11 VAL B1119
ILE B1145
PRO B1112
LEU B1106
ILE A 141
THR B1148
 None
 1.30A 3clbA-5h67B:
undetectable		 3clbA-5h67B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		6 / 12 VAL B1119
ILE B1145
PRO B1112
LEU B1106
ILE A 141
THR B1148
 None
 1.21A 3clbC-5h67B:
undetectable		 3clbC-5h67B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		6 / 11 VAL B1119
ILE B1145
PRO B1112
LEU B1106
ILE A 141
THR B1148
 None
 1.22A 3hbbC-5h67B:
2.0		 3hbbC-5h67B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5h67 SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis) 		4 / 7 ILE C 242
TYR C 241
ILE C 231
GLN C 233
 None
 0.98A 3hgxA-5h67C:
undetectable		 3hgxA-5h67C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5h67 SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis) 		5 / 9 VAL C 220
ILE C 242
TYR C 241
ILE C 231
GLN C 233
 None
 1.24A 3hgxB-5h67C:
undetectable		 3hgxB-5h67C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis;
Bacillus
subtilis) 		6 / 12 VAL B1163
GLY B1162
LEU C 221
ILE B1147
LEU A   6
ILE A  44
 None
 1.20A 3ijdA-5h67B:
undetectable		 3ijdA-5h67B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis;
Bacillus
subtilis) 		6 / 12 VAL B1163
GLY B1162
LEU C 221
ILE B1147
LEU A   6
ILE A  44
 None
 1.21A 3ijdB-5h67B:
undetectable		 3ijdB-5h67B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 ILE B1145
PHE B1113
PHE A   2
ALA A  28
THR A  27
 None
 1.32A 3ndiA-5h67B:
undetectable		 3ndiA-5h67B:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		3 / 3 HIS B1069
SER A 159
GLU A 162
 None
 0.91A 3s8pA-5h67B:
undetectable		 3s8pA-5h67B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 9 PHE A  14
VAL B1173
PHE A  22
ILE A  40
THR A  27
 None
 1.35A 3t3rB-5h67A:
undetectable		 3t3rB-5h67A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 9 PHE A  14
VAL B1173
PHE A  22
ILE A  40
THR A  27
 None
 1.37A 3t3rC-5h67A:
undetectable		 3t3rC-5h67A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 12 ALA A  43
ASP A  42
ASN A  39
ILE B1145
VAL A   8
 None
None
ATP  A1001 (-3.4A)
None
None
 1.06A 3ucbA-5h67A:
undetectable		 3ucbA-5h67A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 7 TYR B1161
VAL A  29
VAL A  23
PHE A  22
ILE A  44
 None
 1.34A 3zjqA-5h67B:
undetectable		 3zjqA-5h67B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 PHE C 237
VAL A  23
PHE A  22
ILE A  40
 None
 0.89A 3zjqA-5h67C:
undetectable		 3zjqA-5h67C:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 7 TYR B1161
VAL A  29
VAL A  23
PHE A  22
ILE A  44
 None
 1.36A 3zjqB-5h67B:
undetectable		 3zjqB-5h67B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 PHE C 237
VAL A  23
PHE A  22
ILE A  40
 None
 0.90A 3zjqB-5h67C:
undetectable		 3zjqB-5h67C:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 11 MET C 202
PHE C 205
LEU C 213
VAL B1176
THR B1164
 None
 1.19A 4eilC-5h67C:
undetectable		 4eilC-5h67C:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 11 MET C 202
PHE C 205
LEU C 213
VAL B1176
THR B1164
 None
 1.20A 4eilE-5h67C:
undetectable		 4eilE-5h67C:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 6 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 0.99A 4f3tA-5h67B:
undetectable		 4f3tA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5h67 SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis) 		5 / 11 THR C 216
LEU C 221
ILE C 242
PHE C 217
LEU C 204
 None
 1.40A 4lhmA-5h67C:
undetectable		 4lhmA-5h67C:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 9 VAL B1146
ILE A  18
VAL B1163
VAL B1159
ALA A  28
 None
 1.25A 4oqrA-5h67B:
undetectable		 4oqrA-5h67B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		4 / 5 GLN A 143
SER A 142
ASP A  42
ASP A  63
 None
 1.14A 4qtuB-5h67A:
undetectable		 4qtuB-5h67A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		4 / 5 GLN A 143
SER A 142
ASP A  42
ASP A  63
 None
 1.17A 4qtuD-5h67A:
undetectable		 4qtuD-5h67A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 5 GLN B1118
SER A 142
ASP A  42
ASP A  63
 ATP  A1001 ( 4.5A)
None
None
None
 1.28A 4qtuD-5h67B:
undetectable		 4qtuD-5h67B:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		4 / 7 PHE B1052
ALA B1100
ILE A 149
LEU B1086
 None
 1.11A 4uymB-5h67B:
undetectable		 4uymB-5h67B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 0.94A 4z4fA-5h67B:
undetectable		 4z4fA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		4 / 8 THR B1097
LEU B1101
ILE A 149
LEU B1102
 None
 0.87A 5g48A-5h67B:
undetectable		 5g48A-5h67B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis) 		5 / 12 VAL A   8
ASP A   7
ALA A  43
ARG A   5
LEU A   3
 None
 1.43A 5syfB-5h67A:
undetectable		 5syfB-5h67A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 0.92A 5t7bA-5h67B:
undetectable		 5t7bA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 5 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 1.03A 5weaA-5h67B:
undetectable		 5weaA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5h67 SEGREGATION AND
CONDENSATION PROTEIN
A
(Bacillus
subtilis) 		3 / 3 TYR C 241
ASP C 203
ASP C 239
 None
 0.79A 5x6yA-5h67C:
undetectable		 5x6yA-5h67C:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 ASP B1117
GLN A 143
GLY A  34
SER A  38
 None
None
ATP  A1001 (-3.4A)
ATP  A1001 (-4.5A)
 0.90A 6ekzA-5h67B:
undetectable		 6ekzA-5h67B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 10 PHE B1113
ILE B1145
LEU B1160
ASP B1158
GLY A  25
 None
 1.43A 6r2eC-5h67B:
undetectable		 6r2eC-5h67B:
18.54