SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A1086
LEU A1089
SER A1090
VAL A 146
 None
 0.93A 1dvxB-5h68A:
undetectable		 1dvxB-5h68A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 139
GLY A 134
LEU A  48
PRO A1112
VAL A 100
 None
 0.81A 1fduA-5h68A:
undetectable		 1fduA-5h68A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 139
GLY A 134
LEU A  48
PRO A1112
VAL A 100
 None
 0.78A 1fduC-5h68A:
undetectable		 1fduC-5h68A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A1105
ALA A 137
PHE A 161
ILE A1074
LEU A1059
 None
 1.19A 1jolA-5h68A:
undetectable		 1jolA-5h68A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A1131
LEU A1123
GLY A1049
GLY A1053
LEU A1116
 None
 0.99A 1p91B-5h68A:
undetectable		 1p91B-5h68A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A1160
ILE A1147
THR A1148
ILE A1145
VAL A1146
 None
 1.15A 1pkvA-5h68A:
undetectable
1pkvB-5h68A:
undetectable		 1pkvA-5h68A:
15.38
1pkvB-5h68A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A1145
VAL A1146
LEU A1160
ILE A1147
THR A1148
 None
 1.16A 1pkvA-5h68A:
undetectable
1pkvB-5h68A:
undetectable		 1pkvA-5h68A:
15.38
1pkvB-5h68A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A1105
ALA A 137
PHE A 161
ILE A1074
LEU A1059
 None
 1.15A 1rx3A-5h68A:
undetectable		 1rx3A-5h68A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A1105
ALA A 137
PHE A 161
ILE A1074
LEU A1059
 None
 1.20A 1tdrA-5h68A:
undetectable		 1tdrA-5h68A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A1086
LEU A1089
SER A1090
VAL A 146
 None
 0.96A 1tyrB-5h68A:
undetectable		 1tyrB-5h68A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A   7
ILE A  82
LEU A   3
GLU A  97
 None
 0.99A 2ya7A-5h68A:
undetectable		 2ya7A-5h68A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A   7
ILE A  82
LEU A   3
GLU A  97
 None
 1.00A 2ya7B-5h68A:
undetectable		 2ya7B-5h68A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A   7
ILE A  82
LEU A   3
GLU A  97
 None
 0.99A 2ya7D-5h68A:
undetectable		 2ya7D-5h68A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A1131
ALA A1132
LEU A1135
ALA A  28
 None
 0.89A 3b6hA-5h68A:
undetectable		 3b6hA-5h68A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A1131
ALA A1132
LEU A1135
ALA A  28
 None
 0.83A 3b6hB-5h68A:
undetectable		 3b6hB-5h68A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A1145
PHE A1113
PHE A   2
ALA A  28
THR A  27
 None
 1.34A 3ndiA-5h68A:
undetectable		 3ndiA-5h68A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A1173
VAL A  18
PHE A  14
VAL A1163
PHE A  22
 None
 1.19A 3u9fH-5h68A:
undetectable
3u9fI-5h68A:
undetectable		 3u9fH-5h68A:
18.48
3u9fI-5h68A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A1105
ALA A 137
PHE A 161
ILE A1074
LEU A1059
 None
 1.19A 4qlfA-5h68A:
undetectable		 4qlfA-5h68A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A  28
THR A  27
ALA A1157
GLY A1162
SER A1181
 None
 1.07A 4qvwK-5h68A:
undetectable
4qvwL-5h68A:
undetectable		 4qvwK-5h68A:
21.02
4qvwL-5h68A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A  28
THR A  27
ALA A1157
GLY A1162
SER A1181
 None
 1.07A 4qvwY-5h68A:
undetectable
4qvwZ-5h68A:
undetectable		 4qvwY-5h68A:
21.02
4qvwZ-5h68A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		6 / 11 GLU A1120
ALA A1132
LEU A1135
TYR A1134
LEU A1116
LEU A1102
 None
 1.42A 4wg0C-5h68A:
undetectable
4wg0D-5h68A:
undetectable
4wg0E-5h68A:
undetectable		 4wg0C-5h68A:
3.26
4wg0D-5h68A:
3.26
4wg0E-5h68A:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		6 / 11 GLU A1120
ALA A1132
LEU A1135
TYR A1134
LEU A1116
LEU A1102
 None
 1.44A 4wg0E-5h68A:
undetectable
4wg0F-5h68A:
undetectable
4wg0G-5h68A:
undetectable		 4wg0E-5h68A:
3.26
4wg0F-5h68A:
3.26
4wg0G-5h68A:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A1086
LEU A1089
SER A1090
VAL A 146
 None
 0.95A 5a6iA-5h68A:
undetectable		 5a6iA-5h68A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  42
GLU A 136
SER A1171
 None
 0.80A 5bw4B-5h68A:
undetectable		 5bw4B-5h68A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5h68 CHROMOSOME PARTITION
PROTEIN SMC
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 134
LEU A  48
GLY A  49
ILE A 160
VAL A 125
 None
 1.07A 6mhtA-5h68A:
undetectable		 6mhtA-5h68A:
21.09