SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 11 PRO A 115
ASP A  92
ASP A  88
LEU A  87
TYR A 118
 None
ZN  A 304 (-3.3A)
ZN  A 304 (-2.7A)
None
None
 1.43A 1c3sA-5h6bA:
2.4		 1c3sA-5h6bA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 11 GLN A 170
GLY A  37
GLY A  76
ILE A  80
GLY A 107
 None
 1.12A 1jg3A-5h6bA:
undetectable		 1jg3A-5h6bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 8 LEU A 224
THR A 193
LEU A 221
VAL A 132
 None
 0.77A 1sn5C-5h6bA:
undetectable		 1sn5C-5h6bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 10 ILE A 177
ASP A 137
SER A  83
PHE A 176
THR A 141
 None
 1.19A 2w9sD-5h6bA:
undetectable		 2w9sD-5h6bA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 10 ILE A 177
ASP A 137
SER A  83
PHE A 176
THR A 141
 None
 1.19A 2w9sF-5h6bA:
undetectable		 2w9sF-5h6bA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 4 VAL A 219
ASP A 239
LEU A  49
ARG A 217
 None
 0.98A 2ziaA-5h6bA:
2.8		 2ziaA-5h6bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 12 VAL A 202
ASP A 200
GLU A 231
LEU A  77
PHE A 153
 None
 1.23A 3j6pB-5h6bA:
4.3		 3j6pB-5h6bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 7 ASP A 137
GLY A 166
THR A 141
PHE A 176
 None
 1.16A 3vnsA-5h6bA:
3.0		 3vnsA-5h6bA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		3 / 3 ASP A  92
LYS A  93
ASP A  96
 ZN  A 304 (-3.3A)
None
None
 0.86A 4a7tA-5h6bA:
undetectable		 4a7tA-5h6bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 7 THR A 164
ILE A 160
THR A  38
GLY A  76
 None
 0.96A 4eq4A-5h6bA:
undetectable		 4eq4A-5h6bA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 8 LEU A 224
THR A 193
LEU A 221
VAL A 132
 None
 0.72A 4ik6B-5h6bA:
undetectable		 4ik6B-5h6bA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 8 LEU A 224
THR A 193
LEU A 221
VAL A 132
 None
 0.75A 4ik7B-5h6bA:
undetectable		 4ik7B-5h6bA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 9 ASP A 228
ALA A 242
ARG A 217
ILE A 195
ILE A 235
 None
 1.33A 4oknB-5h6bA:
3.3		 4oknB-5h6bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 12 PRO A 115
ASP A  92
ASP A  88
LEU A  87
TYR A 118
 None
ZN  A 304 (-3.3A)
ZN  A 304 (-2.7A)
None
None
 1.49A 5ef8B-5h6bA:
2.2		 5ef8B-5h6bA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 12 ALA A  97
TYR A  20
LEU A  87
ILE A  80
GLY A 112
 None
 1.14A 5fsaA-5h6bA:
undetectable		 5fsaA-5h6bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		5 / 12 VAL A 202
ASP A 200
GLU A 231
LEU A  77
PHE A 153
 None
 1.33A 5hnzB-5h6bA:
4.2		 5hnzB-5h6bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 8 ILE A  80
GLY A 111
LEU A 131
LEU A 119
 None
 0.74A 5hs1A-5h6bA:
undetectable		 5hs1A-5h6bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 6 TYR A 199
ASP A 223
ILE A 241
TYR A 210
 None
 1.48A 5igyA-5h6bA:
undetectable		 5igyA-5h6bA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5h6b PUTATIVE SECRETED
LIPASE
(Streptomyces
sp.
W007) 		4 / 6 PHE A 176
PRO A 175
THR A 181
ILE A 177
 None
None
ACT  A 305 (-4.7A)
None
 1.39A 5ih0A-5h6bA:
undetectable		 5ih0A-5h6bA:
21.52