SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 10 VAL A 113
VAL A 148
ILE A 177
PRO A  86
GLY A 171
 None
 1.41A 13gsA-5h6jA:
undetectable		 13gsA-5h6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 9 VAL A 113
VAL A 148
ILE A 177
PRO A  86
GLY A 171
 None
 1.42A 13gsB-5h6jA:
undetectable		 13gsB-5h6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 5h6j PIERISIN-1
(Pieris
rapae) 		6 / 12 THR A 115
ILE A  28
ALA A  15
GLY A 171
ALA A  14
ILE A  12
 None
 1.27A 1bx4A-5h6jA:
undetectable		 1bx4A-5h6jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 11 GLU A 182
ARG A 181
TYR A 140
SER A 179
PHE A  80
 None
 1.46A 1rnrA-5h6jA:
undetectable		 1rnrA-5h6jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 8 ALA A  15
PHE A 168
ALA A 144
LEU A  68
 None
 0.81A 2bxmA-5h6jA:
undetectable		 2bxmA-5h6jA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 4 VAL A  88
THR A  89
VAL A  17
GLY A 170
 None
 1.18A 2p2fB-5h6jA:
undetectable		 2p2fB-5h6jA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 4 LEU A  68
GLN A 165
THR A 115
THR A  56
 None
NAD  A 301 (-3.8A)
None
None
 1.47A 2zj0D-5h6jA:
undetectable		 2zj0D-5h6jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5h6j PIERISIN-1
(Pieris
rapae) 		3 / 3 ASP A  72
ARG A  70
ARG A 227
 NAD  A 301 (-3.8A)
NAD  A 301 (-3.4A)
None
 0.90A 3k37A-5h6jA:
undetectable		 3k37A-5h6jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 5 ARG A 218
ARG A 190
GLY A 224
GLU A 182
 None
 1.25A 3k9fA-5h6jA:
undetectable
3k9fB-5h6jA:
undetectable
3k9fC-5h6jA:
undetectable		 3k9fA-5h6jA:
19.35
3k9fB-5h6jA:
19.35
3k9fC-5h6jA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 12 LEU A  53
GLY A 147
ASP A 149
GLY A 171
ILE A 172
 None
 1.19A 3ku1G-5h6jA:
undetectable		 3ku1G-5h6jA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 12 ALA A 167
SER A 114
GLN A 163
ALA A 157
TYR A 101
 None
NAD  A 301 (-3.1A)
NAD  A 301 (-3.4A)
None
None
 1.30A 4r29A-5h6jA:
undetectable		 4r29A-5h6jA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 7 LEU A  53
THR A  56
THR A 118
LEU A  68
 None
 0.93A 4z91F-5h6jA:
undetectable
4z91G-5h6jA:
undetectable
4z91H-5h6jA:
undetectable
4z91I-5h6jA:
undetectable
4z91J-5h6jA:
undetectable		 4z91F-5h6jA:
21.21
4z91G-5h6jA:
21.21
4z91H-5h6jA:
21.21
4z91I-5h6jA:
21.21
4z91J-5h6jA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5h6j PIERISIN-1
(Pieris
rapae) 		5 / 12 PRO A  93
ALA A  14
ALA A  15
VAL A  17
GLY A 147
 None
 1.40A 5igpA-5h6jA:
undetectable		 5igpA-5h6jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 5h6j PIERISIN-1
(Pieris
rapae) 		3 / 3 GLU A 141
ARG A 178
TYR A 143
 None
 0.62A 5trqB-5h6jA:
undetectable		 5trqB-5h6jA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5h6j PIERISIN-1
(Pieris
rapae) 		4 / 6 ARG A  49
PHE A 112
PHE A 168
ILE A  12
 None
 1.03A 5vceA-5h6jA:
undetectable		 5vceA-5h6jA:
19.33