SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 4 ARG A  17
ALA A  15
ALA A  75
GLU A  71
 None
 1.26A 1e7bA-5h6oA:
undetectable		 1e7bA-5h6oA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		6 / 12 VAL A 202
LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.26A 1sa1A-5h6oA:
undetectable
1sa1B-5h6oA:
undetectable		 1sa1A-5h6oA:
20.52
1sa1B-5h6oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		6 / 12 VAL A 202
LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.29A 1sa1C-5h6oA:
undetectable
1sa1D-5h6oA:
undetectable		 1sa1C-5h6oA:
20.52
1sa1D-5h6oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 8 THR A  10
VAL A  42
ALA A  81
ARG A 212
 None
 0.97A 2ij7C-5h6oA:
undetectable		 2ij7C-5h6oA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 5 GLY A 179
TRP A  24
ARG A 182
LEU A 183
 DPM  A 401 ( 4.9A)
None
DPM  A 401 (-3.6A)
None
 1.10A 2j2pD-5h6oA:
undetectable
2j2pF-5h6oA:
undetectable		 2j2pD-5h6oA:
22.26
2j2pF-5h6oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 5 ARG A 182
ALA A 178
ASP A 109
GLU A 108
 DPM  A 401 (-3.6A)
DPM  A 401 ( 4.4A)
None
None
 1.25A 2xrzA-5h6oA:
undetectable		 2xrzA-5h6oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 11 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.08A 3e22B-5h6oA:
undetectable		 3e22B-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 11 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.07A 3e22D-5h6oA:
undetectable		 3e22D-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		3 / 3 ASN A 226
ALA A 231
ARG A 235
 None
 0.72A 3tj7C-5h6oA:
undetectable
3tj7D-5h6oA:
1.2		 3tj7C-5h6oA:
18.65
3tj7D-5h6oA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 12 MET A 240
LEU A 244
LEU A 296
SER A 302
LEU A 301
 None
 1.44A 4m11A-5h6oA:
undetectable		 4m11A-5h6oA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 12 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.14A 4x1iB-5h6oA:
undetectable		 4x1iB-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 12 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.15A 4x1yB-5h6oA:
undetectable		 4x1yB-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 12 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.07A 4x1yD-5h6oA:
undetectable		 4x1yD-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 11 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.14A 4x20D-5h6oA:
undetectable		 4x20D-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 6 GLU A 237
PRO A 200
GLY A 203
ARG A 107
 None
 1.23A 5jcnB-5h6oA:
undetectable		 5jcnB-5h6oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		3 / 3 LYS A 121
ASP A 124
ARG A 190
 None
 0.83A 5jwaA-5h6oA:
undetectable
5jwaH-5h6oA:
undetectable		 5jwaA-5h6oA:
18.61
5jwaH-5h6oA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A 104
GLY A 208
HIS A  86
VAL A  91
ALA A 231
 None
 1.14A 5n0wA-5h6oA:
2.2		 5n0wA-5h6oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 8 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.83A 5vlmA-5h6oA:
undetectable		 5vlmA-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 8 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.77A 5vlmB-5h6oA:
undetectable		 5vlmB-5h6oA:
21.27