SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		5 / 9 LEU A  28
ILE A  88
PHE A  31
LEU A  11
ILE A  38
 None
 1.28A 2f78B-5h75A:
1.8		 2f78B-5h75A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		5 / 9 LEU A  28
ILE A  88
PHE A  31
LEU A  11
ILE A  38
 None
 1.23A 2f7aB-5h75A:
undetectable		 2f7aB-5h75A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		4 / 5 VAL A 111
THR A 110
VAL A  41
GLY A  14
 None
 0.87A 2p2fA-5h75A:
3.1		 2p2fA-5h75A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		4 / 4 VAL A 111
THR A 110
VAL A  41
GLY A  14
 None
 0.84A 2p2fB-5h75A:
3.2		 2p2fB-5h75A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Bacillus
sp.
HIL-Y85/54728;
Staphylococcus
aureus) 		4 / 7 ALA A 185
ALA A 221
GLU A 220
SER A 206
 None
 0.86A 4r1zB-5h75A:
undetectable		 4r1zB-5h75A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		3 / 3 ILE A 159
ASN A 123
CYH A  16
 None
FAD  A 301 (-4.6A)
FAD  A 301 ( 4.6A)
 0.66A 6bp4A-5h75A:
undetectable		 6bp4A-5h75A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		5 / 12 GLY A  17
THR A  91
ASN A  93
ILE A  94
GLN A  97
 FAD  A 301 (-3.6A)
FAD  A 301 (-3.4A)
FAD  A 301 (-3.9A)
FAD  A 301 ( 4.8A)
FAD  A 301 ( 4.8A)
 1.16A 6exiC-5h75A:
5.1
6exiD-5h75A:
5.3		 6exiC-5h75A:
12.86
6exiD-5h75A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A
(Staphylococcus
aureus;
Bacillus
sp.
HIL-Y85/54728) 		5 / 9 ILE A  15
ILE A  88
GLU A  65
VAL A  40
ILE A  13
 None
 1.40A 6hloA-5h75A:
5.9		 6hloA-5h75A:
17.65