SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		5 / 12 TYR A 167
VAL A 106
LEU A 133
LEU A 132
LEU A  93
 None
 1.35A 1mmkA-5h76A:
undetectable		 1mmkA-5h76A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		5 / 12 ILE A 128
VAL A  63
ILE A  95
GLU A  64
GLU A  61
 None
 1.37A 4i41A-5h76A:
undetectable		 4i41A-5h76A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 1.00A 4p65B-5h76A:
undetectable
4p65D-5h76A:
undetectable
4p65I-5h76A:
undetectable
4p65J-5h76A:
undetectable		 4p65B-5h76A:
10.42
4p65D-5h76A:
10.42
4p65I-5h76A:
5.58
4p65J-5h76A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		5 / 9 PRO A  83
MET A  34
VAL A  30
ILE A  62
TYR A  56
 None
 1.12A 5iepA-5h76A:
undetectable		 5iepA-5h76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		4 / 4 ASP A 112
SER A 111
ASP A 110
HIS A  85
 None
 1.46A 5wyqB-5h76A:
undetectable		 5wyqB-5h76A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A
(Staphylococcus
aureus;
synthetic
construct) 		4 / 4 ILE A 163
LEU A 117
HIS A 171
ALA A 137
 None
 1.02A 6ck2C-5h76A:
undetectable
6ck2D-5h76A:
undetectable		 6ck2C-5h76A:
5.58
6ck2D-5h76A:
9.90