SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 9 ASP A 140
LEU A 183
VAL A 148
ILE A 147
ILE A 105
 None
 1.40A 1q6iA-5h78A:
undetectable		 1q6iA-5h78A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 11 LEU A 131
VAL A 134
VAL A 174
ILE A 127
GLU A 133
 None
 1.06A 2yy8A-5h78A:
undetectable
2yy8B-5h78A:
2.3		 2yy8A-5h78A:
26.70
2yy8B-5h78A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 12 ALA A  92
LEU A 131
ALA A 132
ILE A 105
LEU A 143
 None
 1.05A 3dauA-5h78A:
undetectable		 3dauA-5h78A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 10 ASP A 140
LEU A 183
VAL A 148
ILE A 147
ILE A 105
 None
 1.18A 3kz7A-5h78A:
undetectable		 3kz7A-5h78A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 10 ALA A 132
ILE A 147
ILE A 145
LEU A 183
ILE A 187
 None
 1.04A 4dt8B-5h78A:
undetectable		 4dt8B-5h78A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5h78 CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT,DHR14
(Homo
sapiens;
synthetic
construct) 		5 / 11 ASP A 140
LEU A 183
VAL A 148
ILE A 147
ILE A 105
 None
 1.21A 5d75A-5h78A:
undetectable		 5d75A-5h78A:
21.35