SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		5 / 11 VAL A 143
ILE A 156
LEU A 140
LEU A 100
LEU A 120
 None
 1.27A 2a15A-5h7cA:
undetectable		 2a15A-5h7cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		5 / 11 LEU A 336
VAL A 339
VAL A 379
ILE A 332
GLU A 338
 None
 1.16A 2yy8A-5h7cA:
undetectable
2yy8B-5h7cA:
undetectable		 2yy8A-5h7cA:
20.36
2yy8B-5h7cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		4 / 5 TYR A 210
GLN A 206
ILE A 199
LEU A 203
 None
 1.09A 3ls4L-5h7cA:
undetectable		 3ls4L-5h7cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		3 / 3 LYS A  49
LEU A  45
ALA A  48
 None
 0.72A 4ikiA-5h7cA:
undetectable		 4ikiA-5h7cA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		5 / 10 LEU A 376
LEU A 356
ALA A 357
LEU A 368
LEU A 399
 None
 1.27A 4p65A-5h7cA:
undetectable
4p65B-5h7cA:
undetectable
4p65F-5h7cA:
undetectable
4p65H-5h7cA:
undetectable		 4p65A-5h7cA:
2.97
4p65B-5h7cA:
5.88
4p65F-5h7cA:
5.88
4p65H-5h7cA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		4 / 5 SER A  90
GLU A 135
LYS A 138
ASP A 129
 None
 1.45A 4pclA-5h7cA:
undetectable		 4pclA-5h7cA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		5 / 12 GLN A 166
GLN A 206
PHE A 209
LEU A 163
ILE A 176
 None
 1.36A 5uacC-5h7cA:
undetectable		 5uacC-5h7cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14
(Staphylococcus
aureus;
synthetic
construct) 		5 / 12 LEU A 319
LEU A 316
ILE A 315
ILE A 312
VAL A 289
 None
 1.00A 5uanB-5h7cA:
undetectable		 5uanB-5h7cA:
23.06