SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 5 ALA A 124
PHE A 171
ILE A 157
ASP A 154
 None
None
None
GDP  A 501 (-2.8A)
 1.11A 1yc2D-5h7kA:
undetectable		 1yc2D-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 7 PRO A 347
MET A 345
ARG A 349
GLY A 342
 None
 1.19A 2hs1B-5h7kA:
undetectable		 2hs1B-5h7kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 PHE A 205
GLY A 127
ASP A 154
LEU A 214
ASN A 151
 None
None
GDP  A 501 (-2.8A)
None
GDP  A 501 (-3.3A)
 1.13A 3eeoA-5h7kA:
4.3		 3eeoA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 THR A  39
PHE A 205
GLY A 206
ILE A 229
VAL A 250
 GDP  A 501 (-3.5A)
None
None
None
None
 0.99A 3fzgA-5h7kA:
undetectable		 3fzgA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 10 LEU A  40
ALA A  31
ILE A  33
GLY A 127
ILE A 174
 None
GDP  A 501 ( 4.2A)
None
None
None
 0.95A 3ogqA-5h7kA:
undetectable		 3ogqA-5h7kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 ALA A  31
HIS A  32
GLY A 100
ALA A  77
LEU A  95
 GDP  A 501 ( 4.2A)
None
None
None
None
 1.18A 3tm4B-5h7kA:
2.8		 3tm4B-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 7 PRO A 347
MET A 345
ARG A 349
GLY A 342
 None
 1.16A 3ucbB-5h7kA:
undetectable		 3ucbB-5h7kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 5 LYS A  37
ILE A 115
VAL A  80
ASP A  97
 None
 1.23A 3wzdA-5h7kA:
undetectable		 3wzdA-5h7kA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 5 LEU A  45
SER A  41
ASP A  97
ASP A 107
 None
 1.28A 4qtuD-5h7kA:
undetectable		 4qtuD-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.12A 4ze2A-5h7kA:
undetectable		 4ze2A-5h7kA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 11 LEU A  44
GLY A  49
SER A  41
LEU A  40
ARG A 242
 None
 1.03A 5o96G-5h7kA:
undetectable		 5o96G-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 7 VAL A 299
ILE A 302
VAL A 363
ALA A 312
 None
 0.72A 5osrA-5h7kA:
undetectable		 5osrA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 8 VAL A 118
GLY A  36
LEU A  40
THR A  38
 None
GDP  A 501 (-3.4A)
None
GDP  A 501 (-3.8A)
 1.02A 5sxqB-5h7kA:
undetectable		 5sxqB-5h7kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 8 VAL A 118
GLY A  36
LEU A  40
THR A  38
 None
GDP  A 501 (-3.4A)
None
GDP  A 501 (-3.8A)
 1.02A 5syjA-5h7kA:
undetectable		 5syjA-5h7kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 LEU A 386
GLY A 106
PRO A  99
PHE A 104
THR A 109
 None
 1.34A 5x6yA-5h7kA:
undetectable		 5x6yA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 LEU A 386
GLY A 106
ASP A 107
PHE A 104
THR A 109
 None
 1.32A 5x6yC-5h7kA:
undetectable		 5x6yC-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 5 PRO A 146
VAL A 196
GLY A 206
VAL A 122
 None
 0.89A 6ak3B-5h7kA:
undetectable		 6ak3B-5h7kA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		3 / 3 GLN A 266
TRP A 317
VAL A 296
 None
 1.16A 6auuA-5h7kA:
undetectable		 6auuA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 ASP A  97
ARG A 349
GLY A 372
ALA A 312
VAL A 311
 None
 0.99A 6c2mC-5h7kA:
undetectable		 6c2mC-5h7kA:
18.18