SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
None
0.91A 1e06A-5h7nA:
undetectable
1e06A-5h7nA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 7 LEU A 305
ILE A 330
THR A  94
MET A 322
None
1.22A 1kglA-5h7nA:
undetectable
1kglA-5h7nA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 ALA A 304
ILE A 109
VAL A  98
LEU A  77
ILE A  80
None
1.26A 2h42A-5h7nA:
undetectable
2h42A-5h7nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
None
0.95A 2h42C-5h7nA:
undetectable
2h42C-5h7nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 4 LEU A 382
PRO A 418
LEU A 390
ARG A 447
None
EDO  A 506 (-4.1A)
None
None
1.38A 2qd2A-5h7nA:
undetectable
2qd2A-5h7nA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
None
1.11A 2ve3A-5h7nA:
undetectable
2ve3A-5h7nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 8 THR A  94
LEU A 286
ASP A 288
GLU A 112
None
None
None
MTT  A 501 (-2.9A)
1.07A 2zw9A-5h7nA:
undetectable
2zw9A-5h7nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 6 PHE A 259
ALA A 163
LEU A 248
PRO A 160
EDO  A 505 (-4.9A)
None
None
None
0.98A 3bgdA-5h7nA:
undetectable
3bgdA-5h7nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
None
0.72A 3bjwC-5h7nA:
undetectable
3bjwC-5h7nA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 6 PRO A 127
LEU A 148
ALA A 224
PRO A 126
None
1.34A 3gv1A-5h7nA:
undetectable
3gv1C-5h7nA:
undetectable
3gv1A-5h7nA:
17.15
3gv1C-5h7nA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 6 LEU A 148
ALA A 224
PRO A 126
PRO A 127
None
1.33A 3gv1A-5h7nA:
undetectable
3gv1B-5h7nA:
undetectable
3gv1A-5h7nA:
17.15
3gv1B-5h7nA:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
12 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
PRO A 155
TRP A 231
TYR A 342
MTT  A 501 (-3.1A)
MTT  A 501 (-2.8A)
MTT  A 501 (-3.0A)
MTT  A 501 (-3.0A)
MTT  A 501 (-3.5A)
MTT  A 501 (-3.3A)
MTT  A 501 (-2.8A)
MTT  A 501 (-3.9A)
MTT  A 501 (-2.9A)
MTT  A 501 (-3.6A)
MTT  A 501 (-4.4A)
MTT  A 501 (-4.5A)
0.28A 3jyrA-5h7nA:
59.2
3jyrA-5h7nA:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
MTT  A 501 ( 4.8A)
MTT  A 501 (-4.4A)
MTT  A 501 (-3.5A)
MTT  A 501 (-3.9A)
MTT  A 501 ( 4.3A)
MTT  A 501 (-3.9A)
0.09A 3jyrA-5h7nA:
59.2
3jyrA-5h7nA:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
6 / 7 ASN A  13
TRP A  63
TYR A 156
MET A 331
TRP A 341
ARG A 345
MTT  A 501 ( 4.8A)
MTT  A 501 (-4.4A)
MTT  A 501 (-3.9A)
MTT  A 501 ( 4.3A)
MTT  A 501 (-3.9A)
MTT  A 501 (-3.9A)
0.57A 3jyrA-5h7nA:
59.2
3jyrA-5h7nA:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
None
1.02A 3n8yB-5h7nA:
undetectable
3n8yB-5h7nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 9 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
None
1.11A 3ozvB-5h7nA:
undetectable
3ozvB-5h7nA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 9 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
None
1.22A 3sj4X-5h7nA:
undetectable
3sj4X-5h7nA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
None
None
None
MTT  A 501 (-2.9A)
None
0.83A 3tbgB-5h7nA:
undetectable
3tbgB-5h7nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
None
None
None
MTT  A 501 (-2.9A)
None
0.81A 3tbgD-5h7nA:
undetectable
3tbgD-5h7nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.09A 3tqbA-5h7nA:
undetectable
3tqbA-5h7nA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
None
1.36A 3vwqA-5h7nA:
undetectable
3vwqA-5h7nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
None
1.29A 3vwrA-5h7nA:
undetectable
3vwrA-5h7nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 5 GLU A 309
ASP A 315
ASP A 288
ASN A 295
None
1.37A 3vywD-5h7nA:
undetectable
3vywD-5h7nA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.08A 4ej1B-5h7nA:
undetectable
4ej1B-5h7nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ILE A 267
ALA A 106
LEU A  21
VAL A  24
ILE A  60
None
1.10A 4m2xG-5h7nA:
undetectable
4m2xG-5h7nA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 5 ASN A 268
ALA A  52
GLY A  57
ASP A  15
None
None
None
MTT  A 501 (-3.1A)
0.97A 4n48A-5h7nA:
undetectable
4n48A-5h7nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.13A 4nx7A-5h7nA:
undetectable
4nx7A-5h7nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
None
1.16A 4or0B-5h7nA:
undetectable
4or0B-5h7nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
None
1.11A 4p65E-5h7nA:
undetectable
4p65F-5h7nA:
undetectable
4p65J-5h7nA:
undetectable
4p65L-5h7nA:
undetectable
4p65E-5h7nA:
4.35
4p65F-5h7nA:
5.88
4p65J-5h7nA:
5.88
4p65L-5h7nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 LEU A 116
ILE A 133
LEU A 140
LEU A 123
ALA A 224
None
1.04A 4p65F-5h7nA:
undetectable
4p65H-5h7nA:
undetectable
4p65K-5h7nA:
undetectable
4p65L-5h7nA:
undetectable
4p65F-5h7nA:
5.88
4p65H-5h7nA:
5.88
4p65K-5h7nA:
4.35
4p65L-5h7nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.08A 4qleA-5h7nA:
undetectable
4qleA-5h7nA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.14A 4x5gA-5h7nA:
undetectable
4x5gA-5h7nA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 ALA A 416
LEU A 382
THR A 427
ILE A 426
LEU A 375
None
1.05A 4x5hA-5h7nA:
undetectable
4x5hA-5h7nA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
None
1.21A 5l66H-5h7nA:
undetectable
5l66I-5h7nA:
undetectable
5l66H-5h7nA:
22.22
5l66I-5h7nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
None
1.21A 5l66V-5h7nA:
undetectable
5l66W-5h7nA:
undetectable
5l66V-5h7nA:
22.22
5l66W-5h7nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
4 / 6 LEU A 305
ILE A 330
THR A  94
MET A 322
None
1.29A 5ljeA-5h7nA:
undetectable
5ljeA-5h7nA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 12 PHE A 393
ILE A 179
ALA A 373
ILE A 426
ALA A 434
None
1.10A 5vc0A-5h7nA:
undetectable
5vc0A-5h7nA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
3 / 3 TYR A 156
ASN A 228
LEU A 114
MTT  A 501 (-3.9A)
None
None
0.84A 6b58A-5h7nA:
undetectable
6b58A-5h7nA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
None
1.46A 6bm5A-5h7nA:
undetectable
6bm5A-5h7nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)
5h7n NLRP12-PYD WITH MBP
TAG

(Homo
sapiens)
5 / 11 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
None
1.10A 6hwdV-5h7nA:
undetectable
6hwdV-5h7nA:
10.62