SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		4 / 8 CYH D  95
HIS D 113
CYH D 118
GLY D 120
 ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
ZN  D 204 (-2.3A)
None
 0.49A 1ekjA-5h7sD:
undetectable
1ekjB-5h7sD:
undetectable		 1ekjA-5h7sD:
20.98
1ekjB-5h7sD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		4 / 8 CYH D  95
HIS D 113
CYH D 118
GLY D 120
 ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
ZN  D 204 (-2.3A)
None
 0.47A 1ekjG-5h7sD:
undetectable
1ekjH-5h7sD:
undetectable		 1ekjG-5h7sD:
20.98
1ekjH-5h7sD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		3 / 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.82A 2iwkA-5h7sD:
undetectable		 2iwkA-5h7sD:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		3 / 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.82A 2iwkB-5h7sD:
undetectable		 2iwkB-5h7sD:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		4 / 8 LEU D  39
LEU D  91
LYS D  90
ASN D  89
 None
 1.10A 2xn3A-5h7sD:
undetectable
2xn3B-5h7sD:
undetectable		 2xn3A-5h7sD:
18.15
2xn3B-5h7sD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		3 / 3 CYH D 101
HIS D 100
PHE D  97
 ZN  D 204 (-2.3A)
None
None
 1.00A 3cr4X-5h7sD:
undetectable		 3cr4X-5h7sD:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		3 / 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.77A 3dtuB-5h7sD:
undetectable		 3dtuB-5h7sD:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		3 / 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.75A 3dtuD-5h7sD:
undetectable		 3dtuD-5h7sD:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens) 		4 / 6 ILE D  33
LEU D  55
LYS D  70
GLY D  47
 None
 1.03A 3sj1X-5h7sD:
undetectable		 3sj1X-5h7sD:
17.74