SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1
(Homo
sapiens) 		3 / 3 GLY A 282
ARG A 365
TYR A 280
 None
 0.80A 2opxA-5h7vA:
undetectable		 2opxA-5h7vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 172
LEU A 241
ALA A 299
 None
 0.74A 4iizA-5h7vA:
undetectable		 4iizA-5h7vA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1
(Homo
sapiens) 		5 / 9 LEU A 222
LEU A 219
ILE A 169
GLN A 176
LEU A 179
 None
 1.14A 5ljdA-5h7vA:
undetectable		 5ljdA-5h7vA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1
(Homo
sapiens) 		4 / 8 PHE A 131
VAL A 145
SER A 148
TYR A 146
 None
 0.80A 6huoC-5h7vA:
undetectable
6huoD-5h7vA:
undetectable		 6huoC-5h7vA:
12.83
6huoD-5h7vA:
12.20