SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 THR A 308
GLU A 299
THR A 298
LEU A 269
 None
EDO  A 505 ( 4.2A)
None
None
 1.22A 1d4fC-5h80A:
5.6		 1d4fC-5h80A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 THR A 308
GLU A 299
THR A 298
LEU A 324
 None
EDO  A 505 ( 4.2A)
None
None
 1.39A 1d4fC-5h80A:
5.6		 1d4fC-5h80A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 6 VAL A 322
GLY A 323
ALA A 309
LEU A 313
 None
 0.55A 1e7bB-5h80A:
undetectable		 1e7bB-5h80A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 11 LEU A 237
PHE A 239
LEU A 456
LEU A 408
LEU A 434
 None
 1.23A 1mx1B-5h80A:
undetectable		 1mx1B-5h80A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 11 ILE A 254
ALA A 257
VAL A 210
VAL A 276
ALA A 242
 None
 0.79A 1n4hA-5h80A:
undetectable		 1n4hA-5h80A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 299
VAL A 307
LEU A 291
TYR A  81
ARG A 373
 EDO  A 505 ( 4.2A)
None
None
None
EDO  A 505 (-4.1A)
 1.35A 1p5zB-5h80A:
undetectable		 1p5zB-5h80A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 VAL A 372
GLY A 371
VAL A 397
TRP A 301
 None
 1.20A 1tkqB-5h80A:
undetectable		 1tkqB-5h80A:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 8 THR A 220
LEU A 319
VAL A 322
GLY A 323
 None
 0.87A 2a1oA-5h80A:
undetectable		 2a1oA-5h80A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 8 ASP A 226
LEU A 444
LEU A 404
LEU A 408
 None
 1.01A 2bfpA-5h80A:
undetectable		 2bfpA-5h80A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 113
THR A 108
ALA A 122
ALA A 287
PHE A 284
 None
 0.98A 2gluB-5h80A:
2.7		 2gluB-5h80A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 299
VAL A 307
LEU A 291
TYR A  81
ARG A 373
 EDO  A 505 ( 4.2A)
None
None
None
EDO  A 505 (-4.1A)
 1.40A 2no0A-5h80A:
undetectable		 2no0A-5h80A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 GLN A 247
THR A 251
ARG A 250
ALA A 329
 None
 1.17A 2qhfA-5h80A:
undetectable		 2qhfA-5h80A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 8 LYS A 235
ASN A 288
ARG A 290
GLU A 294
 None
 0.87A 2ys6A-5h80A:
27.0		 2ys6A-5h80A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 5 LEU A 444
GLN A 230
THR A 228
HIS A 436
LEU A 456
 None
 1.47A 3ce6D-5h80A:
5.2		 3ce6D-5h80A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 6 GLN A 262
LEU A 260
GLU A 263
LEU A 121
 None
None
EDO  A 504 (-3.9A)
EDO  A 504 (-4.8A)
 0.94A 3h5gA-5h80A:
undetectable
3h5gC-5h80A:
undetectable		 3h5gA-5h80A:
4.93
3h5gC-5h80A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 4 GLY A 216
VAL A 219
GLY A 270
THR A 271
 None
 0.93A 3ib2A-5h80A:
undetectable		 3ib2A-5h80A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		3 / 3 PRO A 367
PHE A 364
ALA A 393
 None
 0.60A 3itaD-5h80A:
undetectable		 3itaD-5h80A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 7 HIS A 295
GLU A  18
ARG A  16
GLU A  12
 None
 1.33A 3ql6A-5h80A:
undetectable		 3ql6A-5h80A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 6 GLU A 294
ARG A 342
GLU A 209
GLU A 273
 None
 1.47A 4kr3A-5h80A:
2.4		 4kr3A-5h80A:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		7 / 7 LYS A 235
ASN A 288
ARG A 290
GLN A 292
VAL A 293
GLU A 294
ARG A 342
 None
 0.66A 4mv7A-5h80A:
50.9		 4mv7A-5h80A:
40.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 ILE A 202
PHE A 272
SER A 445
HIS A 447
 None
 1.25A 4rzvB-5h80A:
0.8		 4rzvB-5h80A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 4 LEU A 311
ILE A   7
HIS A  78
VAL A  21
 None
 1.31A 4xyzA-5h80A:
undetectable		 4xyzA-5h80A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 222
GLY A 270
GLY A 214
VAL A 219
THR A 220
 None
 1.32A 5o4yD-5h80A:
undetectable
5o4yE-5h80A:
undetectable		 5o4yD-5h80A:
2.40
5o4yE-5h80A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 TRP A 223
GLU A 224
VAL A 210
LEU A 306
 None
 1.47A 5qjqA-5h80A:
0.0
5qjqB-5h80A:
0.0		 5qjqA-5h80A:
17.60
5qjqB-5h80A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 VAL A 210
LEU A 306
TRP A 223
GLU A 224
 None
 1.50A 5qjqA-5h80A:
undetectable
5qjqB-5h80A:
undetectable		 5qjqA-5h80A:
17.60
5qjqB-5h80A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		4 / 5 GLU A 299
THR A 298
HIS A 221
LEU A 324
 EDO  A 505 ( 4.2A)
None
None
None
 1.33A 5utuH-5h80A:
2.4		 5utuH-5h80A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		3 / 3 GLU A 224
TRP A 301
HIS A 221
 None
 0.91A 5xipA-5h80A:
3.1		 5xipA-5h80A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 10 PHE A 364
LEU A 382
GLY A 422
ILE A 420
PHE A 377
 None
 1.16A 6ebpB-5h80A:
undetectable		 6ebpB-5h80A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 267
GLY A 316
GLU A 317
 None
 0.61A 6fgdA-5h80A:
4.6		 6fgdA-5h80A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 11 PHE A 364
LEU A 382
GLY A 422
ILE A 420
PHE A 377
 None
 1.07A 6gp2A-5h80A:
undetectable		 6gp2A-5h80A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5h80 CARBOXYLASE
(Deinococcus
radiodurans) 		5 / 11 PHE A 364
LEU A 382
GLY A 422
ILE A 420
PHE A 377
 None
 1.02A 6gp2B-5h80A:
undetectable		 6gp2B-5h80A:
8.88