SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		4 / 7 ILE A 152
ARG A  30
TYR A  12
PHE A  28
 None
 0.98A 1e71M-5h82A:
undetectable		 1e71M-5h82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		4 / 7 ILE A 152
ARG A  30
TYR A  12
PHE A  28
 None
 0.98A 1e72M-5h82A:
undetectable		 1e72M-5h82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		4 / 6 ILE A 152
ARG A  30
TYR A  12
PHE A  28
 None
 0.98A 1e73M-5h82A:
1.3		 1e73M-5h82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		5 / 12 PHE A 285
GLY A 199
GLY A 261
LEU A 278
VAL A 211
 None
 1.07A 2zulA-5h82A:
8.9		 2zulA-5h82A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		4 / 5 PHE A 213
ILE A 198
ASN A 331
PHE A 263
 None
 1.15A 3octA-5h82A:
undetectable		 3octA-5h82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		5 / 10 ILE A 364
LEU A 368
GLY A  46
ASP A  51
GLY A  69
 None
 1.07A 4bwlC-5h82A:
undetectable		 4bwlC-5h82A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		5 / 9 ASP A 335
VAL A 211
ALA A 210
PHE A 203
GLY A 207
 None
 1.05A 4mmeB-5h82A:
undetectable		 4mmeB-5h82A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		3 / 3 TYR A 120
THR A 121
THR A 124
 None
 0.82A 5aoxB-5h82A:
undetectable		 5aoxB-5h82A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		5 / 12 MET A 341
ILE A 364
ASP A  51
ALA A  16
THR A 124
 None
 1.24A 5igiA-5h82A:
undetectable		 5igiA-5h82A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		3 / 3 GLY A 102
CYH A 107
CYH A 104
 ZN  A1002 ( 4.9A)
ZN  A1002 (-2.3A)
ZN  A1002 (-2.3A)
 0.90A 5inzB-5h82A:
undetectable		 5inzB-5h82A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		4 / 4 LEU A 275
ARG A 307
ILE A 262
PHE A 285
 None
 1.22A 5kirB-5h82A:
undetectable		 5kirB-5h82A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5h82 HETEROYOHIMBINE
SYNTHASE THAS2
(Catharanthus
roseus) 		5 / 12 VAL A 173
ASP A  51
VAL A  52
VAL A 361
TYR A 149
 None
 1.28A 6h7lA-5h82A:
undetectable		 6h7lA-5h82A:
12.76