SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		5 / 12 ARG A 381
GLY A 345
GLU A 468
GLU A 463
HIS A 454
 None
 1.29A 1jdvE-5h8aA:
undetectable
1jdvF-5h8aA:
undetectable		 1jdvE-5h8aA:
22.96
1jdvF-5h8aA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 460
PHE A 393
VAL A 374
 None
 0.77A 1kijB-5h8aA:
undetectable		 1kijB-5h8aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 393
ILE A 432
GLY A 405
PHE A 395
 None
 0.80A 1rtsA-5h8aA:
undetectable		 1rtsA-5h8aA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 391
ARG A 351
ILE A 382
SER A 378
PHE A 393
 None
 1.27A 2vdyB-5h8aA:
undetectable		 2vdyB-5h8aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 316
PHE A 318
ILE A 448
GLY A 469
SER A 470
 None
 1.21A 3n8xA-5h8aA:
undetectable		 3n8xA-5h8aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 349
HIS A 348
SER A 350
 None
 1.01A 4mjwA-5h8aA:
undetectable
4mjwB-5h8aA:
undetectable		 4mjwA-5h8aA:
14.02
4mjwB-5h8aA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 350
ARG A 349
HIS A 348
 None
 0.99A 4mjwA-5h8aA:
undetectable
4mjwB-5h8aA:
undetectable		 4mjwA-5h8aA:
14.02
4mjwB-5h8aA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 347
PRO A 337
ILE A 335
SER A 470
ARG A 338
 None
 1.39A 4uroB-5h8aA:
undetectable		 4uroB-5h8aA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 393
ILE A 432
GLY A 405
PHE A 395
 None
 0.73A 5h3aB-5h8aA:
undetectable		 5h3aB-5h8aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 5 ALA A 407
VAL A 409
PHE A 395
ILE A 382
 None
 0.96A 5of1A-5h8aA:
undetectable		 5of1A-5h8aA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 5 ALA A 407
VAL A 409
PHE A 395
ILE A 382
 None
 0.93A 5of1B-5h8aA:
undetectable		 5of1B-5h8aA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 393
ILE A 432
GLY A 405
PHE A 395
 None
 0.80A 5x5qC-5h8aA:
undetectable		 5x5qC-5h8aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 393
ILE A 432
GLY A 405
PHE A 395
 None
 0.81A 5x5qD-5h8aA:
undetectable		 5x5qD-5h8aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 393
ILE A 432
GLY A 405
PHE A 395
 None
 0.81A 5x5qF-5h8aA:
undetectable		 5x5qF-5h8aA:
21.48