SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 GLU A  96
TYR A  70
PHE A  94
 None
 0.74A 1eqbB-5h8kA:
undetectable		 1eqbB-5h8kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 GLU A  96
TYR A  70
PHE A  94
 None
 0.75A 1eqbA-5h8kA:
undetectable		 1eqbA-5h8kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 GLU A  96
TYR A  70
PHE A  94
 None
 0.75A 1eqbD-5h8kA:
undetectable		 1eqbD-5h8kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 GLU A  96
TYR A  70
PHE A  94
 None
 0.76A 1eqbC-5h8kA:
undetectable		 1eqbC-5h8kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 10 ILE A 153
LEU A 178
PHE A 179
MET A 170
ALA A 169
 None
 1.44A 1ju6C-5h8kA:
undetectable		 1ju6C-5h8kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		4 / 5 SER A  12
VAL A 215
VAL A 260
SER A 217
 None
 1.32A 2j9cA-5h8kA:
undetectable
2j9cB-5h8kA:
undetectable
2j9cC-5h8kA:
undetectable		 2j9cA-5h8kA:
17.76
2j9cB-5h8kA:
17.76
2j9cC-5h8kA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		4 / 8 THR A 227
GLN A  59
SER A 232
TYR A  54
 None
None
None
GOL  A 402 (-4.4A)
 0.85A 2xz5C-5h8kA:
undetectable
2xz5D-5h8kA:
undetectable		 2xz5C-5h8kA:
18.51
2xz5D-5h8kA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		6 / 11 GLY A 238
ALA A 183
THR A 182
ARG A 219
GLU A 223
ALA A 259
 None
 1.44A 3g88A-5h8kA:
undetectable		 3g88A-5h8kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		6 / 11 GLY A 238
ALA A 183
THR A 182
ARG A 219
GLU A 223
ALA A 259
 None
 1.44A 3g88B-5h8kA:
undetectable		 3g88B-5h8kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		6 / 11 GLY A 238
ALA A 183
THR A 182
ARG A 219
GLU A 223
ALA A 259
 None
 1.46A 3g89B-5h8kA:
undetectable		 3g89B-5h8kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		6 / 12 GLY A 238
ALA A 183
THR A 182
ARG A 219
GLU A 223
ALA A 259
 None
 1.43A 3g8bA-5h8kA:
undetectable		 3g8bA-5h8kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		6 / 12 GLY A 238
ALA A 183
THR A 182
ARG A 219
GLU A 223
ALA A 259
 None
 1.44A 3g8bB-5h8kA:
undetectable		 3g8bB-5h8kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 PHE A 136
GLN A 161
PHE A  55
 None
 0.81A 3rv5A-5h8kA:
undetectable		 3rv5A-5h8kA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 12 ASP A 110
ILE A 157
PHE A 146
ALA A 166
ALA A 175
 None
 1.13A 3ua1A-5h8kA:
undetectable		 3ua1A-5h8kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 4 SER A 192
GLY A 129
GLU A 132
 None
 0.62A 4juoA-5h8kA:
undetectable
4juoC-5h8kA:
undetectable		 4juoA-5h8kA:
20.59
4juoC-5h8kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 12 ALA A  13
ILE A 242
PHE A 179
LEU A 267
ILE A  43
 None
 1.00A 4km0B-5h8kA:
undetectable		 4km0B-5h8kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		4 / 5 ILE A 118
ASP A  72
GLU A  96
VAL A  92
 None
 1.21A 4nkxC-5h8kA:
undetectable		 4nkxC-5h8kA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 11 ILE A 234
GLY A 221
ILE A 220
THR A 182
ILE A 184
 GOL  A 402 ( 4.9A)
None
None
None
GOL  A 402 (-4.6A)
 0.96A 4rvjA-5h8kA:
undetectable		 4rvjA-5h8kA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 11 ILE A 234
GLY A 221
ILE A 220
THR A 182
ILE A 184
 GOL  A 402 ( 4.9A)
None
None
None
GOL  A 402 (-4.6A)
 0.96A 4rvjC-5h8kA:
undetectable		 4rvjC-5h8kA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		3 / 3 THR A 182
ASN A 218
SER A 217
 None
 0.77A 4tvtA-5h8kA:
undetectable		 4tvtA-5h8kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		4 / 5 ALA A 183
GLU A  48
ASN A 104
GLU A 132
 None
 1.46A 5dwkC-5h8kA:
undetectable		 5dwkC-5h8kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		4 / 5 HIS A 206
LEU A  45
TYR A 119
PHE A 143
 None
 1.31A 5igjA-5h8kA:
undetectable		 5igjA-5h8kA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE
(Medicago
truncatula) 		5 / 12 ASP A 110
ILE A 157
PHE A 146
ALA A 166
ALA A 175
 None
 1.15A 5vcgA-5h8kA:
undetectable		 5vcgA-5h8kA:
21.61